| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ambrosio G and Tritto I | Reperfusion injury: experimental evidence and clinical implications. | 1999 | Am. Heart J. | pmid:10426862 |
| Maruyama M et al. | Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs. | 1990 | Am. Heart J. | pmid:2389687 |
| Schwinger RH et al. | Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium. | 1992 | Am. Heart J. | pmid:1322030 |
| Kwiterovich PO | The antiatherogenic role of high-density lipoprotein cholesterol. | 1998 | Am. J. Cardiol. | pmid:9819099 |
| Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
| Shohet RV et al. | Plasma platelet-activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis. | 1999 | Am. J. Cardiol. | pmid:10073795 |
| Zhang C et al. | The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. | 2004 | Am. J. Chin. Med. | pmid:15154282 |
| Prescott SM | What are the effects of dietary fatty acid modification on platelet eicosanoid metabolism, platelet-activating factor, and platelet function? How might these metabolic alterations influence thrombosis? | 1992 | Am. J. Clin. Nutr. | pmid:1414987 |
| Sandler RM et al. | Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. | 1985 | Am. J. Clin. Pathol. | pmid:4003343 |
| Sandberg-Gertzén H | An open trial of Cedemin, a Gingko biloba extract with PAF-antagonistic effects for ulcerative colitis. | 1993 | Am. J. Gastroenterol. | pmid:8470656 |
| Braquet P | Cedemin, a Ginkgo biloba extract, should not be considered as a PAF antagonist. | 1993 | Am. J. Gastroenterol. | pmid:8110248 |
| Verhoef G and Boogaerts M | Treatment with granulocyte-macrophage colony stimulating factor and the adult respiratory distress syndrome. | 1991 | Am. J. Hematol. | pmid:1672790 |
| Rao AK et al. | Platelet-activating factor is a weak platelet agonist: evidence from normal human platelets and platelets with congenital secretion defects. | 1984 | Am. J. Hematol. | pmid:6431801 |
| Issekutz AC and Ripley M | The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. | 1986 | Am. J. Hematol. | pmid:2934975 |
| Radhika V et al. | Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants. | 1996 | Am. J. Hematol. | pmid:8756080 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Marx G et al. | Nutritional zinc increases platelet reactivity. | 1991 | Am. J. Hematol. | pmid:1951315 |
| Pelczar-Wissner CJ et al. | Absence of platelet activating factor (PAF) mediated platelet aggregation: a new platelet defect. | 1984 | Am. J. Hematol. | pmid:6720685 |
| Yoshida H et al. | Activity of platelet-activating factor acetylhydrolase exists in red cell membrane. | 1992 | Am. J. Hematol. | pmid:1566749 |
| Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
| Hollister AS et al. | Humoral factor, intraplatelet calcium, and hypertension. | 1992 | Am. J. Hypertens. | pmid:1632935 |
| Macconi D et al. | Defective platelet aggregation in response to platelet-activating factor in uremia associated with low platelet thromboxane A2 generation. | 1992 | Am. J. Kidney Dis. | pmid:1562019 |
| Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |
| Tanaka R et al. | Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. | 1999 | Am. J. Kidney Dis. | pmid:10430976 |
| Hall AV et al. | Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. | 1993 | Am. J. Kidney Dis. | pmid:8352261 |
| Gallego MJ et al. | Cyclosporine enhances leukocyte adhesion to vascular endothelium under physiologic flow conditions. | 1996 | Am. J. Kidney Dis. | pmid:8712218 |
| Xu H et al. | Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. | 2000 | Am. J. Kidney Dis. | pmid:10873870 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |
| Ganong BR | Roles of lipid turnover in transmembrane signal transduction. | 1991 | Am. J. Med. Sci. | pmid:1661067 |
| Muirhead EE et al. | Biologic contrasts between medullipin I and vasoactive glyceryl compounds. | 1989 | Am. J. Med. Sci. | pmid:2764021 |
| Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Perico N and Remuzzi G | Role of platelet-activating factor in renal immune injury and proteinuria. | 1990 | Am. J. Nephrol. | pmid:2256482 |
| Kees-Folts D and Diamond JR | Relationship between hyperlipidemia, lipid mediators, and progressive glomerulosclerosis in the nephrotic syndrome. | 1993 | Am. J. Nephrol. | pmid:8116689 |
| Camussi G et al. | Platelet-activating factor in renal diseases. | 1989 | Am. J. Nephrol. | pmid:2646923 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Narahara H and Johnston JM | Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. | 1993 | Am. J. Obstet. Gynecol. | pmid:8372856 |
| Claman P | Platelet activating factor does not improve intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717679 |
| Benedetto C et al. | Reduced serum inhibition of platelet-activating factor activity in preeclampsia. | 1989 | Am. J. Obstet. Gynecol. | pmid:2912073 |
| Morris C et al. | Effects of platelet-activating factor on prostaglandin E2 production by intact fetal membranes. | 1992 | Am. J. Obstet. Gynecol. | pmid:1566774 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Zhu YP et al. | The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. | 1992 | Am. J. Obstet. Gynecol. | pmid:1314480 |
| Matorras R and Pijoan JI | The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904634 |
| Hoffman DR et al. | Detection of platelet-activating factor in amniotic fluid of complicated pregnancies. | 1990 | Am. J. Obstet. Gynecol. | pmid:2309839 |
| Roudebush WE et al. | Platelet activating factor enhances in vitro fertilization of rabbit oocytes. | 1990 | Am. J. Obstet. Gynecol. | pmid:2240122 |
| Minhas BS et al. | Effects of platelet activating factor on mouse oocyte fertilization in vitro. | 1989 | Am. J. Obstet. Gynecol. | pmid:2603931 |
| Minhas BS | Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475981 |