Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
| Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
| Min JH et al. | Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | 2001 | Biochemistry | pmid:11294621 |
| Richardson RM et al. | RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. | 2001 | Biochemistry | pmid:11297424 |
| Kuijpers TW et al. | The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase. | 2001 | Clin. Exp. Immunol. | pmid:11298128 |
| Teeling JL et al. | Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model. | 2001 | Br. J. Haematol. | pmid:11298603 |
| Teather LA et al. | Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. | 2001 | Neurobiol Learn Mem | pmid:11300737 |
| Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
| Ilveskero S et al. | Procoagulant activity on platelets adhered to collagen or plasma clot. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304482 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Dery RE et al. | Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). | 2001 Jan-Mar | Int. Arch. Allergy Immunol. | pmid:11306968 |
| Lukashova V et al. | G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. | 2001 | J. Biol. Chem. | pmid:11309383 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Panayiotou A et al. | Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): correlation with platelet-activating factor and atherogenesis. | 2000 | J. Agric. Food Chem. | pmid:11312810 |
| Yildirim G et al. | Does the platelet-activating factor affect the antioxidant defense system? The possible role of hyperbaric oxygenation. | 2000 | Biol Trace Elem Res | pmid:11318001 |
| Yan GT et al. | [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. | 1998 | Sheng Li Xue Bao | pmid:11324524 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |
| Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
| Caplan MS et al. | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. | 2001 | Pediatr. Res. | pmid:11328947 |
| Sugano T et al. | Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts. | 2001 | Mol. Hum. Reprod. | pmid:11331671 |
| Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
| Vittimberga FJ et al. | Endotoxin fails to stimulate inositol triphosphate production in macrophages. | 1999 | Int. J. Surg. Investig. | pmid:11341611 |
| Hattar K et al. | Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. | 2001 | J. Immunol. | pmid:11342652 |
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Wu C et al. | Evidence for the autocrine induction of capacitation of mammalian spermatozoa. | 2001 | J. Biol. Chem. | pmid:11350972 |
| Taylor R et al. | Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. | 2001 | Clin. Sci. | pmid:11352774 |
| Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
| Lee T et al. | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. | 2001 | Arch. Biochem. Biophys. | pmid:11368182 |
| Tu W et al. | [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372382 |
| Iwase M et al. | Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor. | 2001 | Crit. Care Med. | pmid:11373429 |
| Rosa MS et al. | Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | 2001 | Curr. Microbiol. | pmid:11375661 |
| Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
| Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
| Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
| Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
| Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
| Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
| Briton-Jones C et al. | The effects of follicular fluid and platelet-activating factor on motion characteristics of poor-quality cryopreserved human sperm. | 2001 | J. Assist. Reprod. Genet. | pmid:11411433 |
| Mizuno S et al. | Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. | 2001 | Dig. Dis. Sci. | pmid:11414308 |
| Jehle R et al. | Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia. | 2001 | Biochim. Biophys. Acta | pmid:11420174 |
| Kulikov VI and Muzya GI | Inhibition of human platelet aggregation by amides and ester of salicylic acid with platelet-activating factor analogs. | 2001 | Biochemistry Mosc. | pmid:11421815 |
| Virchow JC et al. | Effect of a specific cysteinyl leukotriene-receptor 1-antagonist (montelukast) on the transmigration of eosinophils across human umbilical vein endothelial cells. | 2001 | Clin. Exp. Allergy | pmid:11422147 |
| Wang H et al. | Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. | 2001 | Br. J. Pharmacol. | pmid:11429396 |
| Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |