Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
Partrick DA et al. | Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. | 1999 | J. Surg. Res. | pmid:10452867 |
Sakaguchi T et al. | Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. | 1999 | J. Surg. Res. | pmid:10452877 |
Dervenis C et al. | Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. | 1999 | Int. J. Pancreatol. | pmid:10453421 |
Nikbakht-Sangari M et al. | Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. | 1999 | Immunol. Invest. | pmid:10454000 |
Subbanagounder G et al. | Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | 1999 | Circ. Res. | pmid:10455059 |
Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
Downing SJ et al. | Effect of inflammatory mediators on the electrophysiology of the human oviduct. | 1999 | Biol. Reprod. | pmid:10456842 |
Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
Zardini DM et al. | Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. | 1999 | Cell Calcium | pmid:10463102 |