Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
| Zhou X and He P | Temporal and spatial correlation of platelet-activating factor-induced increases in endothelial [Ca²âº]i, nitric oxide, and gap formation in intact venules. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21873500 |
| Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
| Curry FE et al. | Thrombin increases permeability only in venules exposed to inflammatory conditions. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12893636 |
| Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
| Finnegan EM et al. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17483236 |
| Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| He P et al. | Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16517944 |
| Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
| Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
| Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Thom SR et al. | Roles for platelet-activating factor and *NO-derived oxidants causing neutrophil adherence after CO poisoning. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11454599 |
| Juchem G et al. | Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22081707 |
| Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
| Sánchez FA et al. | Functional significance of differential eNOS translocation. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16679407 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Guequén A et al. | S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921435 |
| Jiang Y et al. | Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18515648 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
| Sharma J et al. | Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21984569 |
| Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
| Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
| Rastogi P et al. | Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18790994 |
| Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
| Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
| Koyama S et al. | The potential of various lipopolysaccharides to release IL-8 and G-CSF. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749742 |
| Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
| Alloatti G et al. | Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11080081 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
| Handa RK et al. | Platelet-activating factor and solute transport processes in the kidney. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12529272 |
| Meyer MC et al. | Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16079184 |
| McHowat J et al. | Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21228317 |
| Dinubile MJ | Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17428843 |
| Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
| Fazal N et al. | PAF receptor antagonist modulates neutrophil responses with thermal injury in vivo. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546669 |
| Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
| Hermle T et al. | Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16723509 |
| Meyer MC et al. | Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15643055 |
| Kaul DK et al. | Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16738001 |