Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Leukostasis D018921 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Migraine without Aura D020326 1 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Anthrax D000881 1 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Multiple Trauma D009104 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Ileitis D007079 2 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Contracture D003286 3 associated lipids
Toxemia D014115 3 associated lipids
Bronchial Diseases D001982 3 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Ileal Diseases D007077 3 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Dyslexia D004410 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Cluster Headache D003027 4 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytosis D013922 4 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Viremia D014766 4 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Burns, Inhalation D002059 4 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Masugi F et al. Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. 1985 Sep-Oct Hypertension pmid:4030044
Yamazaki H [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. 1986 Nippon Naika Gakkai Zasshi pmid:3027214
Rink TJ Stimulus-response coupling mechanisms in human platelets. 1986 Agents Actions Suppl. pmid:3028101
Baroggi N et al. Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. 1986 Agents Actions Suppl. pmid:3028108
Hwang SB et al. Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. 1986 J. Biol. Chem. pmid:3020044
Biftu T et al. Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. 1986 J. Med. Chem. pmid:3020247
Zanetti A et al. The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. 1986 Eur. J. Pharmacol. pmid:2944757
Bush LR and Smith SG Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. 1986 Thromb. Res. pmid:2948294
Valone FH and Ruis NM Platelet-activating factor binding to human platelet membranes. 1986 Biotechnol. Appl. Biochem. pmid:3021183
Braquet P Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. 1986 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2949548
Naccache PH et al. Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. 1986 J. Leukoc. Biol. pmid:3021882
Panchenko EP et al. [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. 1986 Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR pmid:3801147
Chamone DF et al. Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. 1986 Braz. J. Med. Biol. Res. pmid:3801724
Toth PD and Mikulaschek AW Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. 1986 Circ. Shock pmid:3802423
Desquand S et al. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. 1986 Eur. J. Pharmacol. pmid:3019727
Daniel LW et al. A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. 1986 J. Biol. Chem. pmid:3087989
Simpson AW et al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. 1986 FEBS Lett. pmid:3086128
Nakaya H and Tohse N Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. 1986 Br. J. Pharmacol. pmid:3814909
Schlondorff D et al. Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. 1986 Am. J. Physiol. pmid:3087218
Coëffier E et al. Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. 1986 Eur. J. Pharmacol. pmid:3816952
Oda M et al. Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. 1986 J. Biochem. pmid:3818574
Nishihira J and Ishibashi T A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. 1986 Lipids pmid:3821393
Kloprogge E et al. Stimulus-aggregation coupling in platelets activated with PAF-acether. 1986 Biochim. Biophys. Acta pmid:3089297
Lynch JM and Henson PM The intracellular retention of newly synthesized platelet-activating factor. 1986 J. Immunol. pmid:3093579
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
Gillespie MN and Bowdy BD Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. 1986 J. Pharmacol. Exp. Ther. pmid:3944767
Viero P et al. Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. 1986 Ann. Intern. Med. pmid:3946966
Siafaka-Kapadai A et al. Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. 1986 Biochem. Int. pmid:3947373
McNamara PJ et al. Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). 1986 Biochem. Pharmacol. pmid:3947392
Anderson RC et al. Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. 1986 Chem. Phys. Lipids pmid:3948294
Davis RB and Johnson MF Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. 1986 Thromb. Res. pmid:3544327
Patscheke H and Dierichs R Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. 1986 Eur. J. Cell Biol. pmid:3084260
O'Flaherty JT et al. Binding and metabolism of platelet-activating factor by human neutrophils. 1986 J. Clin. Invest. pmid:3016027
Hanahan DJ Platelet activating factor: a biologically active phosphoglyceride. 1986 Annu. Rev. Biochem. pmid:3017194
Bette-Bobillo P et al. Interaction between blood components and a spin-labeled analogue of PAF-acether. 1986 Biochim. Biophys. Acta pmid:3017416
Levesque JP et al. Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3018735
Raaijmakers JA et al. Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. 1986 Eur. J. Pharmacol. pmid:3019725
Foegh ML et al. Fatty acids and eicosanoids in organ transplantation. 1986 Prog. Lipid Res. pmid:3321095
Dewald B and Baggiolini M Platelet-activating factor as a stimulus of exocytosis in human neutrophils. 1986 Biochim. Biophys. Acta pmid:3017443
Ostermann G et al. Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. 1986 Thromb. Res. pmid:3764811
First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. 1986 Transplant. Proc. pmid:3765055
Satoh K and Takamatsu S [Inactivation by plasma of platelet-activating factor]. 1986 Nippon Ketsueki Gakkai Zasshi pmid:3766067
Gordeev KIu et al. [Synthesis of thioanalogs of platelet activating factor (PAF)]. 1986 Bioorg. Khim. pmid:3768051
Hoffman DR et al. Metabolism and function of platelet-activating factor in fetal rabbit lung development. 1986 Biochim. Biophys. Acta pmid:3768390
Thomas Y et al. [Synthesis of paf-acether by E. coli K12]. 1986 C. R. Acad. Sci. III, Sci. Vie pmid:3101984
Küster LJ and Frölich JC Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. 1986 Prostaglandins pmid:3097760
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Hwang SB et al. Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. 1986 J. Biol. Chem. pmid:3001070