Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
| Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
| Paubert-Braquet M et al. | Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. | 1990 | Adv. Exp. Med. Biol. | pmid:2173875 |
| Vernadakis A et al. | C-6 glioma cells of early passage have progenitor properties in culture. | 1991 | Adv. Exp. Med. Biol. | pmid:1685850 |
| Yue TL et al. | Platelet-activating factor (PAF)--a putative mediator in inflammatory tissue injury. | 1991 | Adv. Exp. Med. Biol. | pmid:1667965 |
| Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Schlondorff D | Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. | 1989 | Adv. Exp. Med. Biol. | pmid:2696352 |
| Remuzzi G | Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. | 1989 | Adv. Exp. Med. Biol. | pmid:2696353 |
| Rabinovici R et al. | PAF and TNF alpha interactions in the pathophysiology of septic shock. | 1991 | Adv. Exp. Med. Biol. | pmid:1818486 |
| Jin N et al. | Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. | 1991 | Adv. Exp. Med. Biol. | pmid:1803920 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. | 1993 | Adv. Exp. Med. Biol. | pmid:7911646 | |
| Camussi G et al. | The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes. | 1982 | Adv. Exp. Med. Biol. | pmid:7090917 |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
| Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
| Hanahan DJ | The continuing biochemical challenge of PAF and closely related lipid mediators. | 1996 | Adv. Exp. Med. Biol. | pmid:9131117 |
| Snyder F et al. | Biosynthesis of platelet-activating factor and enzyme inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131118 |
| Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Morooka S and Natsume Y | Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131147 |
| Sanchez Crespo M et al. | Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131148 |
| Saito K | PAF response to inflammatory and non-inflammatory stimuli. | 1996 | Adv. Exp. Med. Biol. | pmid:9131150 |
| Silver D et al. | Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131151 |
| Lopes-Martins RA et al. | Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. | 1996 | Adv. Exp. Med. Biol. | pmid:9131152 |
| Camussi G et al. | Platelet-activating factor and angiogenesis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131153 |
| Oh-Ishi S et al. | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131154 |
| Tetta C et al. | The role of platelet-activating factor in the biocompatibility of hemodialysis membranes. | 1996 | Adv. Exp. Med. Biol. | pmid:9131156 |
| O'Neill C | PAF promotes the development of the preimplantation embryo. | 1996 | Adv. Exp. Med. Biol. | pmid:9131158 |
| Ammit AJ and O'Neill C | PAF released by preimplantation embryos binds to albumin. | 1996 | Adv. Exp. Med. Biol. | pmid:9131159 |
| Narahara H et al. | Role of platelet-activating factor in parturition. | 1996 | Adv. Exp. Med. Biol. | pmid:9131160 |
| Ahmed A and Dearn S | The role of platelet-activating factor and its receptor in endometrial receptivity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131161 |
| Korth RM | Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131162 |
| Zimmerman GA et al. | Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. | 1996 | Adv. Exp. Med. Biol. | pmid:9131163 |
| Yang HC et al. | Characterization of plasmalogen-selective phospholipase A2 from bovine brain. | 1996 | Adv. Exp. Med. Biol. | pmid:9131165 |
| Elizarova EP | Effects of taurine on calcium in platelets and their aggregation. | 1996 | Adv. Exp. Med. Biol. | pmid:8915398 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
| Kosar-Hashemi B et al. | Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. | 1993 | Adv. Exp. Med. Biol. | pmid:8304231 |
| Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
| Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |