Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ottlakán A | Role of platelet-activating factor in glucose uptake and utilization of different tissues. | 1998 | Eur Surg Res | pmid:9838231 |
| Travers J et al. | Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783. | 1998 | Arch. Dermatol. Res. | pmid:9836508 |
| Dupuis F et al. | Effect of platelet-activating factor on the growth of human erythroid and myeloid CD34+ progenitors. | 1998 | Mediators Inflamm. | pmid:9836496 |
| Stack WA et al. | Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis. | 1998 | Gastroenterology | pmid:9834260 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Ohashi H et al. | Sulochrin inhibits eosinophil activation and chemotaxis. | 1998 | Inflamm. Res. | pmid:9831326 |
| Itabe H | Oxidized phospholipids as a new landmark in atherosclerosis. | 1998 Jul-Aug | Prog. Lipid Res. | pmid:9829125 |
| Smalley DM et al. | Platelet activating factor (PAF) increases leukocyte adhesion but does not alter vessel diameter in the rat mesenteric microcirculation. | 1998 | Microvasc. Res. | pmid:9828165 |
| Kilgore KS et al. | Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: the roles of P-selectin and platelet activating factor. | 1998 | Inflammation | pmid:9824773 |
| Pulliam L et al. | Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. | 1998 | J. Neurosci. Res. | pmid:9822163 |
| Akisü M et al. | Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia? | 1998 | Acta Paediatr Jpn | pmid:9821700 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Malpuech-Brugère C et al. | Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. | 1998 | Life Sci. | pmid:9820125 |
| Siafaka-Kapadai A et al. | Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists. | 1998 | Life Sci. | pmid:9820121 |
| Kwiterovich PO | The antiatherogenic role of high-density lipoprotein cholesterol. | 1998 | Am. J. Cardiol. | pmid:9819099 |
| Nakos G et al. | Bronchoalveolar lavage alterations in pulmonary embolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817700 |
| Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
| Denizot Y et al. | Effects of lipid mediators on the synthesis of leukaemia inhibitory factor and interleukin 6 by human bone marrow stromal cells. | 1998 | Cytokine | pmid:9811531 |
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| Aida Y et al. | Effects of chroman derivatives on platelet aggregation induced by some aggregating agents in rabbits. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9807668 |