Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kern H et al. | Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group. | 1998 | Biochim. Biophys. Acta | pmid:9767093 |
| Bozza PT et al. | Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. | 1998 | J. Leukoc. Biol. | pmid:9766638 |
| Marriott I et al. | Differential kinetics for induction of interleukin-6 mRNA expression in murine peritoneal macrophages: evidence for calcium-dependent and independent-signalling pathways. | 1998 | J. Cell. Physiol. | pmid:9766520 |
| Kabasakal C et al. | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. | 1998 Jul-Sep | Turk. J. Pediatr. | pmid:9763906 |
| Spoelstra FM et al. | Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. | 1998 | Eur. Respir. J. | pmid:9762784 |
| Tamm M et al. | Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9761763 |
| Kinn JW and Bache RJ | Effect of platelet activation on coronary collateral blood flow. | 1998 | Circulation | pmid:9760298 |
| El-Shazly A et al. | Human eotaxin induces eosinophil-derived neurotoxin release from normal human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758899 |
| Matsumoto K et al. | Altered expression of CD11b and CD62L after cross-linking of CD45 isoforms on human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758894 |
| El-Shazly A et al. | Modulation of normal human eosinophil chemotaxis in vitro by herbimycin A, erbstatin and pervanadate. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758889 |
| Heath MF et al. | Dextran-70 inhibits equine platelet aggregation induced by PAF but not by other agonists. | 1998 | Equine Vet. J. | pmid:9758098 |
| Endo S et al. | Administration of methylprednisolone acetate into the subdural cavity in an infant with subdural fluid collection. PAF is a good indicator of the efficacy of the treatment. | 1998 | Childs Nerv Syst | pmid:9753399 |
| Rocha MF et al. | Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta. | 1998 | Infect. Immun. | pmid:9746596 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Kruse-Elliott KT et al. | Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. | 1998 | Shock | pmid:9744648 |
| Liu L et al. | Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator. | 1998 | J. Immunol. | pmid:9743372 |
| Cheryk LA et al. | Alterations in blood platelet morphology during aggregate formation in the Asian elephant (Elephas maximus). | 1998 | J. Zoo Wildl. Med. | pmid:9732033 |
| M'Rabet L et al. | Activation of the small GTPase rap1 in human neutrophils. | 1998 | Blood | pmid:9731072 |
| Burke-Gaffney A and Hellewell PG | A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730868 |
| Ueno M et al. | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. | 1998 | Pharmacology | pmid:9730778 |