Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Albert DH et al. | The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435164 |
Li CL and Wong YY | The bioavailability of ginkgolides in Ginkgo biloba extracts. | 1997 | Planta Med. | pmid:9434615 |
Dupuis F et al. | Production, metabolism and effect of platelet-activating factor on the growth of the human K562 erythroid cell line. | 1997 | Biochim. Biophys. Acta | pmid:9434130 |
Bennett SA and Birnboim HC | Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor. | 1997 | Mol. Carcinog. | pmid:9433481 |
Stack WA and Hawkey CJ | Specific mediator-directed therapy for gastrointestinal diseases. | 1997 | Eur J Gastroenterol Hepatol | pmid:9431894 |
Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
Igarashi Y | [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. | 1997 | Seikagaku | pmid:9431007 |
Hichami A et al. | Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells. | 1997 | Eur. J. Biochem. | pmid:9428670 |
Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
Shamsuddin M et al. | Regulation of leukotriene and platelet-activating factor synthesis in human alveolar macrophages. | 1997 | J. Lab. Clin. Med. | pmid:9422335 |
Mugnai S et al. | Influence of interleukin 1alpha on superoxide anion, platelet activating factor release and phospholipase A2 activity of naive and sensitized guinea-pig alveolar macrophages. | 1997 | Br. J. Pharmacol. | pmid:9421281 |
Prescott SM | Inflammatory actions of platelet-activating factor: control by PAF acetylhydrolase. | 1997 Sep-Oct | J Investig Allergol Clin Immunol | pmid:9416565 |
Maeda T et al. | Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. | 1997 | Acta Neurochir. Suppl. | pmid:9416292 |
Manabe H et al. | KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414145 |
Sozzani S et al. | Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor. | 1997 | FEBS Lett. | pmid:9414103 |
Zimmerman GA et al. | Adhesion and signaling in vascular cell-cell interactions. | 1997 | J. Clin. Invest. | pmid:9413392 |
Bix GJ and Clark GD | Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro. | 1998 | J. Neurosci. | pmid:9412509 |
Kertscher HP | [PAF-antagonists with lipid structure. 6. Alkylpropandiol lipids with acyl- and ether- structures at the C-3 position and heterocyclic head groups; synthesis, characterization and structure-activity relationship]. | 1997 | Pharmazie | pmid:9411454 |
Camici M et al. | [Platelet activating factor (PAF) and kidney failure progression]. | 1997 | Minerva Med. | pmid:9411309 |
Zinchenko VP et al. | [Effect of structural analogs of platelet activating factor on the intracellular signal transduction in murine peritoneal neutrophils and macrophages of P388D1 line]. | 1997 Sep-Oct | Biofizika | pmid:9410037 |
Adachi T et al. | PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells. | 1997 | Neurosci. Lett. | pmid:9406887 |
Tabuchi S et al. | Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. | 1997 | Neurosci. Lett. | pmid:9406868 |
Coffer PJ et al. | Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. | 1998 | Biochem. J. | pmid:9405284 |
Soubeyrand S et al. | Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase. | 1998 | Biochem. J. | pmid:9405273 |
Uozumi N et al. | Role of cytosolic phospholipase A2 in allergic response and parturition. | 1997 | Nature | pmid:9403692 |
Lo CJ et al. | Endotoxin-induced macrophage gene expression depends on platelet-activating factor. | 1997 | Arch Surg | pmid:9403541 |
Bix GJ and Clark GD | Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. | 1997 | J. Neurosci. Methods | pmid:9402559 |
Erickson KL et al. | Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. | 1997 | J. Leukoc. Biol. | pmid:9400826 |
el-Shazly AE et al. | Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. | 1997 Aug-Dec | Immunol. Invest. | pmid:9399104 |
Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
Negro Alvarez JM et al. | Platelet-activating factor antagonists. | 1997 Sep-Oct | Allergol Immunopathol (Madr) | pmid:9395010 |
Im SY et al. | Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. | 1997 | Eur. J. Immunol. | pmid:9394802 |
Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
Cheng D and Chen W | [The role of platelet activating factor in chronic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389061 |
Cheng D et al. | [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389027 |
Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
Yu P et al. | [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. | 1996 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:9387456 |
Sapir T et al. | Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. | 1997 | EMBO J. | pmid:9384577 |
Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
Kozai T et al. | Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. | 1997 | Coron. Artery Dis. | pmid:9383603 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Mantovani A | The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. | 1997 | Drugs | pmid:9378074 |
Okada S et al. | Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9376127 |
Mori M et al. | Localization of platelet-activating factor receptor messenger RNA in the rat eye. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375587 |
Bazan HE et al. | Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375567 |
Miyahara T et al. | Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. | 1997 | J. Appl. Physiol. | pmid:9375313 |
Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |