Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
Sakellariou M et al. | Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18248752 |
Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
Arai H | Platelet-activating factor acetylhydrolase. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432911 |
Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
Shibamoto T et al. | Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303618 |
Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
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Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
Touvay C et al. | Effect of long-term infusion of platelet-activating factor on pulmonary responsiveness and morphology in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1804494 |
Salari H and Schellenberg RR | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1991 | Pulm Pharmacol | pmid:1804490 |
Macquin-Mavier I et al. | Effects of platelet-activating factor on lung epithelial permeability in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1806136 |
Underwood SL et al. | RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. | 1992 | Pulm Pharmacol | pmid:1280178 |
Lai CK and Holgate ST | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1992 | Pulm Pharmacol | pmid:1591466 |
Spina D et al. | The role of platelet activating factor in allergic inflammation. | 1989 | Pulm Pharmacol | pmid:2520484 |
Björck T and Dahlén SE | Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. | 1993 | Pulm Pharmacol | pmid:8477156 |
Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
Barnes PJ | The changing face of asthma. | 1987 | Q. J. Med. | pmid:3310071 |
Weintraub ST et al. | Electrospray ionization for analysis of platelet-activating factor. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1841648 |
Smith JC et al. | Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | 2008 | Rapid Commun. Mass Spectrom. | pmid:18937225 |
Kasperska-Zajac A et al. | Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. | 2008 | Recent Pat Inflamm Allergy Drug Discov | pmid:19075994 |
Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
Resetkova E et al. | Effect of human thyroglobulin on the production of platelet activating factor from peripheral blood mononuclear cells from patients with autoimmune thyroid diseases. | 1992 Jul-Aug | Reg Immunol | pmid:1476872 |
Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
Wallace JL et al. | Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. | 1993 | Regul. Pept. | pmid:7901873 |
Iwamoto I et al. | Role of leukotriene B4 in substance P-induced granulocyte infiltration in mouse skin. | 1993 | Regul. Pept. | pmid:7692497 |
Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
Pirotzky E et al. | Platelet-activating factor antagonist, BN-52021 protects against cis-diamminedichloroplatinum nephrotoxicity in the rat. | 1990 | Ren Fail | pmid:2287769 |
Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
Tiemann U | The role of platelet-activating factor in the mammalian female reproductive tract. | 2008 | Reprod. Domest. Anim. | pmid:18363604 |
Hynes AC et al. | The phosphatidylinositol signalling system in elongating bovine blastocysts; formation of phosphoinositides, inositol phosphates and stimulation by growth factors. | 2002 | Reprod. Fertil. Dev. | pmid:12617797 |
O'Neill C et al. | Outcome of pregnancies resulting from a trial of supplementing human IVF culture media with platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1585005 |
Ryan JP et al. | Metabolic and developmental responses of preimplantation embryos to platelet activating factor (PAF). | 1992 | Reprod. Fertil. Dev. | pmid:1461990 |
Pike IL et al. | Actions of platelet activating factor (PAF) on gametes and embryos: clinical aspects. | 1992 | Reprod. Fertil. Dev. | pmid:1461991 |
O'Neill C | Embryo-derived platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1438959 |
Kojima T et al. | Production and secretion of progesterone in vitro and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. | 1993 | Reprod. Fertil. Dev. | pmid:8234890 |
Dusting GJ and Stewart AG | Overview of eicosanoid metabolism and relationship to platelet-activating factor. | 1990 | Reprod. Fertil. Dev. | pmid:2075239 |
O'Neill C et al. | Embryo-derived platelet activating factor: interactions with the arachidonic acid cascade and the establishment and maintenance of pregnancy. | 1990 | Reprod. Fertil. Dev. | pmid:2075241 |
Roberts C et al. | Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos. | 1993 | Reprod. Fertil. Dev. | pmid:8272531 |
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Bloom JW et al. | Intravenous platelet activating factor does not affect lung epithelial permeability. | 1987 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3326081 |
Chand N et al. | Inhibition of PAF-induced histamine secretion and bronchoconstriction by WEB 2086. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1691522 |
Janero DR and Burghardt C | Production and release of platelet-activating factor by the injured heart-muscle cell (cardiomyocyte). | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2333409 |
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Ng DS and Wong K | Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2557657 |
Miller LG et al. | Platelet activating factor antagonists interact with GABAA receptors. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1667341 |
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