Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Dictyocaulus Infections D004022 1 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Migraine without Aura D020326 1 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Anthrax D000881 1 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Leukostasis D018921 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Ileitis D007079 2 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Multiple Trauma D009104 2 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Ileal Diseases D007077 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Toxemia D014115 3 associated lipids
Contracture D003286 3 associated lipids
Bronchial Diseases D001982 3 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Burns, Inhalation D002059 4 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytosis D013922 4 associated lipids
Cluster Headache D003027 4 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Brain Injuries D001930 4 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Pi F et al. Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. 1994 Transplantation pmid:8291097
Herrero-Fresneda I et al. Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. 2000 Transplantation pmid:11190497
Makowka L et al. Platelet-activating factor and hyperacute rejection. The effect of a platelet-activating factor antagonist, SRI 63-441, on rejection of xenografts and allografts in sensitized hosts. 1990 Transplantation pmid:2402783
Biancone L et al. Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. 2006 Transplantation pmid:16495796
Gu M et al. Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. 2000 Transplantation pmid:11045637
Saumweber DM et al. Hyperacute rejection in an ex vivo model of renal xenografting. Role of the mediator response and its pharmacologic manipulation by the specific platelet-activating factor antagonist WEB 2086BS. 1994 Transplantation pmid:8108870
Biancone L et al. Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. 2000 Transplantation pmid:11063341
Yin M et al. The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. 1996 Transplantation pmid:8633367
Takada Y et al. Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation. 1995 Transplantation pmid:7839408
Watson CJ et al. The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival. 1993 Transplantation pmid:8212192
Suzuki S et al. The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. 2000 Transplantation pmid:10868624
Marathe GK et al. Oxidized LDL contains inflammatory PAF-like phospholipids. 2001 Apr-May Trends Cardiovasc. Med. pmid:11686003
Zimmerman GA and McIntyre TM PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. 2004 Trends Mol Med pmid:15177186
Braquet P et al. Is there a case for PAF antagonists in the treatment of ischemic states? 1989 Trends Pharmacol. Sci. pmid:2688213
Izzo AA et al. Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide. 1998 Trends Pharmacol. Sci. pmid:9803830
Page C and Abbott A PAF: new antagonists, new roles in disease and a major role in reproductive biology. 1989 Trends Pharmacol. Sci. pmid:2672467
García-Sáinz JA Intercellular communication within the liver has clinical implications. 1989 Trends Pharmacol. Sci. pmid:2595791
O'Neill C A physiological role for PAF in the stimulation of mammalian embryonic development. 1991 Trends Pharmacol. Sci. pmid:2053190
GamaleÄ­ IA et al. [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. 1999 Tsitologiia pmid:10496012
Harputluoglu MM et al. The effects of Gingko biloba extract on acetic acid-induced colitis in rats. 2006 Turk J Gastroenterol pmid:16941250
Kabasakal C et al. The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. 1998 Jul-Sep Turk. J. Pediatr. pmid:9763906
Hansen JF and Hansen BF [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. 1987 Ugeskr. Laeg. pmid:3324429
Vavilova GL et al. [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. 1996 Mar-Apr Ukr. Biokhim. Zh. pmid:9005660
Yildirim G et al. Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. 2000 Undersea Hyperb Med pmid:11191161
Mehta A and Sigman M Identification and preparation of sperm for ART. 2014 Urol. Clin. North Am. pmid:24286775
Imagawa M et al. Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. 1996 Urol. Int. pmid:8840484
Rastogi P et al. Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. 2011 Urology pmid:21094990
Baka S et al. Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. 2009 Urology pmid:19716589
Kim YH et al. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. 2015 Vascul. Pharmacol. pmid:25967595
Marathe GK et al. Activation of vascular cells by PAF-like lipids in oxidized LDL. 2002 Vascul. Pharmacol. pmid:12449015
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Kulikov VI and Muzia GI [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1801455
Fedorov NA [Physiological variants of functional and biochemical indicators of thrombocytes]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1801458
Kaminskaia GO and Aladysheva ZhI [Platelet activating factor and pulmonary tuberculosis]. 1995 Vestn. Akad. Med. Nauk SSSR pmid:7670343
Strukova SM et al. [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1724858
Shabanov VV [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. 2003 Vestn. Akad. Med. Nauk SSSR pmid:14598737
Moore RM et al. Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. 1998 Jan-Feb Vet Surg pmid:9449176
Leid RW and Potter KA Inflammation and mediators of lung injury. 1985 Vet. Clin. North Am. Food Anim. Pract. pmid:3907779
Alarcón P et al. D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. 2011 Vet. Immunol. Immunopathol. pmid:21816488
Carretta MD et al. Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. 2016 Vet. Immunol. Immunopathol. pmid:27288853
Waller KP Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. 1997 Vet. Immunol. Immunopathol. pmid:9261962
Conejeros I et al. 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. 2012 Vet. Immunol. Immunopathol. pmid:22226550
Cook VL et al. The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. 2009 Vet. Immunol. Immunopathol. pmid:19136156
Aktan I et al. PKC isoenzymes in equine platelets and stimulus induced activation. 2011 Vet. Immunol. Immunopathol. pmid:21513989
Topper EK et al. Induction of tissue eosinophilia by platelet-activating factor in Merino sheep. 1992 Vet. Immunol. Immunopathol. pmid:1604802
Foster AP et al. Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. 1995 Vet. Immunol. Immunopathol. pmid:7747395
Brooks AC et al. CXCL8 attenuates chemoattractant-induced equine neutrophil migration. 2011 Vet. Immunol. Immunopathol. pmid:21040981
Corl CM et al. Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. 2010 Vet. Immunol. Immunopathol. pmid:20359754
Strøm H and Thomsen MK Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. 1990 Vet. Immunol. Immunopathol. pmid:2396362
Larrazabal CS et al. Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. 2017 Vet. Immunol. Immunopathol. pmid:28895869
Marr KA et al. Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. 1999 Vet. Immunol. Immunopathol. pmid:10532398
Van de Weerdt ML et al. Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. 1999 Vet. J. pmid:10030127
Michelotto PV et al. Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. 2011 Vet. J. pmid:22108190
da Silva MB et al. Effect of ketoprofen on PAF-induced bovine platelet aggregation. 1998 Vet. J. pmid:9564275
Slauson DO and Sanchez-Vizcaino JM Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. 1981 Vet. Pathol. pmid:6170156
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
Van de Weerdt ML et al. Effect of platelet-activating factor on bovine pulmonary function. 1997 Vet. Rec. pmid:9290195
Bastos da Silva M et al. Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. 1997 Sep-Oct Vet. Res. pmid:9342825
Lallès JP et al. Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. 1998 Jan-Feb Vet. Res. pmid:9559521
Bastos da Silva M et al. In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. 2000 Mar-Apr Vet. Res. pmid:10779205
Diez-Fraile A et al. Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. 2003 Jan-Feb Vet. Res. pmid:12588684
Bastos da Silva MB et al. The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. 1997 Vet. Res. Commun. pmid:9345719
da Silva MB et al. Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. 1998 Vet. Res. Commun. pmid:9686442
Dawson J et al. Platelet activating factor as a mediator of equine cell locomotion. 1988 Vet. Res. Commun. pmid:3188378
Venugopalan CS et al. Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. 1998 Vet. Res. Commun. pmid:9868763
DaÄ­khin EI et al. [Clinical significance of studies of platelet activating factor (review of the literature)]. 1989 Mar-Apr Vopr. Med. Khim. pmid:2662595
Shebzukhov IuV and Mysiakin EB [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. 1996 Oct-Dec Vopr. Med. Khim. pmid:9254510
Muzia GI et al. [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. 1995 Jul-Aug Vopr. Med. Khim. pmid:8571587
Denizot Y and Nathan N Platelet-activating factor in operative salvaged blood. 1994 Vox Sang. pmid:7801619
Silliman CC et al. Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. 1992 Vox Sang. pmid:1332255
Sieunarine K et al. Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. 1992 Vox Sang. pmid:1333134
Robeva R et al. [Changes in blood coagulation in glomerulonephritis]. 1982 Vutr Boles pmid:6219496
Guan Z et al. [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. 2000 Wei Sheng Yan Jiu pmid:12725051
Chmiel B [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. 2002 Wiad. Lek. pmid:12715347
Keck M et al. Pathophysiology of burns. 2009 Wien Med Wochenschr pmid:19652939
Czarnetzki BM [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. 1987 Wien Med Wochenschr Suppl pmid:3078398
Connolly AB and Vernon DR Manipulations of the metabolic response for management of patients with severe surgical illness: review. 2000 World J Surg pmid:10773122
Bang UC et al. Pharmacological approach to acute pancreatitis. 2008 World J. Gastroenterol. pmid:18494044
Xia SH et al. Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. 2007 World J. Gastroenterol. pmid:17589953
Xia SH et al. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. 2013 World J. Gastroenterol. pmid:23840141
Chen Y et al. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. 2008 World J. Gastroenterol. pmid:18186558
Lu YY et al. Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. 2008 World J. Gastroenterol. pmid:18205269
Cao HC et al. Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. 2005 World J. Gastroenterol. pmid:16437644
Bock J et al. Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. 2007 World J. Gastroenterol. pmid:17876892
Liu LR and Xia SH Role of platelet-activating factor in the pathogenesis of acute pancreatitis. 2006 World J. Gastroenterol. pmid:16489665
Zhou ZG and Chen YD Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. 2002 World J. Gastroenterol. pmid:12046059
Torres MI and Rios A Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. 2008 World J. Gastroenterol. pmid:18395894
Yang YP et al. Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. 2006 World J. Gastroenterol. pmid:16521183
Mathonnet M et al. Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. 2006 World J. Gastroenterol. pmid:16718768
Karidis NP et al. Platelet-activating factor in liver injury: a relational scope. 2006 World J. Gastroenterol. pmid:16773686
Zhao H et al. Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. 2003 World J. Gastroenterol. pmid:12532462
Sperling RI Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis. 1991 World Rev Nutr Diet pmid:2053354
Tanaka E et al. Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog. 1994 Xenobiotica pmid:8059533
Nunoya K et al. S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. 1995 Xenobiotica pmid:8719904
Thomson KL et al. Metabolism of the platelet-activating factor antagonist (+/-)-trans-2-(3'-methoxy-5'-methylsulphonyl-4'-propoxyphenyl)-5-(3",4" ,5"- trimethoxyphenyl)tetrahydrofuran (L-659,989) in rhesus monkeys. 1991 Xenobiotica pmid:1949894
Kobayashi T et al. Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. 1988 Xenobiotica pmid:3354232
Kusano K et al. Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? 1993 Xenobiotica pmid:8212733
Kusano K et al. Metabolic polymorphism of E6123 in rhesus monkey. 1993 Xenobiotica pmid:8212734
Matsubara C et al. [Densitometric quantitation of platelet activating factor and other phospholipids in human saliva using enzyme reaction on a silica plate]. 1994 Yakugaku Zasshi pmid:7965653
Ohishi S [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. 2000 Yakugaku Zasshi pmid:10825809