Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mann O et al. | Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | 2009 | Pancreas | pmid:18695628 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Castro DP et al. | Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. | 2009 | J. Insect Physiol. | pmid:19232405 |
| Yao Y et al. | Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. | 2009 | J. Immunol. | pmid:19234179 |
| Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
| Marotta DM et al. | Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. | 2009 | Biochem. Pharmacol. | pmid:19283893 |
| Yost CC et al. | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. | 2009 | Blood | pmid:19221037 |
| Tsoupras AB et al. | The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. | 2009 | Infect Disord Drug Targets | pmid:19689381 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Wijman CA | Is platelet activity important in acute intracerebral hemorrhage? | 2009 | Neurocrit Care | pmid:19714496 |
| Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
| Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Kovacova E et al. | General changes in hemostasis in gastric cancer. | 2009 | Bratisl Lek Listy | pmid:19507648 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Tang WZ et al. | Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19496609 |
| Hakim-Rad K et al. | Mast cells: makers and breakers of allergic inflammation. | 2009 | Curr Opin Allergy Clin Immunol | pmid:19550301 |
| Li Y et al. | Activation of a chloride channel by a trophic ligand is required for development of the mouse preimplantation embryo in vitro. | 2009 | Biol. Reprod. | pmid:19553604 |
| Deng Y et al. | Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. | 2009 | Eur. J. Pharmacol. | pmid:19555682 |
| Edwards LJ and Constantinescu CS | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. | 2009 | Inflamm Allergy Drug Targets | pmid:19601878 |
| Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
| Xu J et al. | Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles. | 2009 | Cytometry A | pmid:19565634 |
| Eggert D et al. | Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. | 2009 | J. Neuroimmunol. | pmid:19541372 |
| Mayerle J | A novel role for leucocytes in determining the severity of acute pancreatitis. | 2009 | Gut | pmid:19834113 |
| Pantaler E and Lückhoff A | Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894037 |
| Guo CJ et al. | The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. | 2008 Sep-Oct | J Asian Nat Prod Res | pmid:19003620 |
| Kurdiumov IN et al. | [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | 2008 Jul-Aug | Eksp Klin Farmakol | pmid:18819437 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Fang H et al. | Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. | 2008 | Microbiol. Immunol. | pmid:18667035 |
| Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Aomatsu K et al. | Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. | 2008 | Immunology | pmid:17662043 |
| Sakellariou M et al. | Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18248752 |
| Yuhki K et al. | Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18256172 |
| Chia YC et al. | Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. | 2008 | Molecules | pmid:18259135 |
| Kasperska-Zajac A et al. | Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. | 2008 | Inflammation | pmid:18193345 |
| Vadas P et al. | Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172172 |
| Burks AW | Factoring PAF in anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172180 |
| Caprani A et al. | Preliminary study of pulsed-electromagnetic fields effects on endothelial (HUVEC) cell secretions--modulation of the thrombo-hemorrhagic balance. | 2008 | Electromagn Biol Med | pmid:19037787 |
| Satoh K | [Plasma platelet-activating factor acetylhydrolase (PAF-AH) deficiency as a risk factor for stroke]. | 2008 | Brain Nerve | pmid:19069165 |
| Hemetsberger R et al. | Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. | 2008 | Coron. Artery Dis. | pmid:19005299 |
| Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
| Zhang Y et al. | Glycosides from the bark of Adina polycephala. | 2008 | J. Nat. Prod. | pmid:18303851 |
| Tsuchiya R et al. | Characterization of canine platelet activation induced by platelet activating factor (PAF). | 2008 | J. Vet. Med. Sci. | pmid:18319579 |
| Song W et al. | Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica. | 2008 | J. Nat. Prod. | pmid:18321056 |
| Shiva D et al. | High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. | 2008 | Immunol. Lett. | pmid:18433880 |
| Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
| Cooper D et al. | Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. | 2008 | J. Leukoc. Biol. | pmid:18372340 |