Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Pietsch P et al. | Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9593076 |
Jackson JR et al. | The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. | 1998 | Biochim. Biophys. Acta | pmid:9593866 |
Colak O et al. | The effect of Ginkgo biloba on the activity of catalase and lipid peroxidation in experimental strangulation ileus. | 1998 | Int. J. Clin. Lab. Res. | pmid:9594365 |
Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
Yamada M et al. | Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages. | 1998 | Life Sci. | pmid:9600332 |
Lie WJ et al. | Degranulation of human basophils by picomolar concentrations of IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor. | 1998 | J. Allergy Clin. Immunol. | pmid:9600507 |
Giménez R and Aguilar J | Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats. | 1998 | Eur. J. Pharmacol. | pmid:9600649 |
László F and Whittle BJ | Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9600654 |
Gómez FP et al. | The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603138 |
O'Neill C | Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. | 1998 | Biol. Reprod. | pmid:9603268 |
Kotelevets L et al. | Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. | 1998 | J. Biol. Chem. | pmid:9603913 |
ZaÄtseva LG et al. | [The role of platelet activating factor in regulation of the phagocytic function of macrophages from different organs]. | 1998 | Biull Eksp Biol Med | pmid:9606554 |
Nguyen P et al. | [Modulators of leukocytic functions]. | 1998 | J Mal Vasc | pmid:9608925 |
Nakos G et al. | Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. | 1998 | Intensive Care Med | pmid:9609406 |
Tsuji F and Shirasawa E | The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs. | 1998 | Curr. Eye Res. | pmid:9617545 |
Shimada A et al. | In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. | 1998 | J. Invest. Dermatol. | pmid:9620295 |
Mollinedo F et al. | Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. | 1998 | J. Leukoc. Biol. | pmid:9620662 |
Lou YP et al. | Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620929 |
Lapchyns'ka II | [Platelet activating factor and its role in the pathogenesis of immune glomerulopathy]. | 1998 Jan-Feb | Lik. Sprava | pmid:9621619 |
Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |