Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
| Wang MM et al. | In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. | 1999 | Biochim. Biophys. Acta | pmid:9989266 |
| Snyder F | The ether lipid trail: a historical perspective. | 1999 | Biochim. Biophys. Acta | pmid:9989259 |
| Syrbu SI et al. | Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. | 1999 | J. Immunol. | pmid:9973512 |
| Hayani KC et al. | Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children. | 1999 | J. Infect. Dis. | pmid:9952364 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Piwinski JJ et al. | Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934454 |
| Lee LW et al. | Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. | 1999 | Eur. J. Pharmacol. | pmid:9932729 |
| Ohshige A et al. | Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. | 1999 | Obstet Gynecol | pmid:9932551 |
| Bazan NG | The neuromessenger platelet-activating factor in plasticity and neurodegeneration. | 1998 | Prog. Brain Res. | pmid:9932449 |
| McCall MR et al. | Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility. | 1999 | Biochim. Biophys. Acta | pmid:9931415 |
| Onorato JM et al. | Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928437 |
| Berger A et al. | Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927381 |
| Toledano BJ et al. | Characterization of B lymphocytes rescued from apoptosis by platelet-activating factor. | 1999 | Cell. Immunol. | pmid:9918687 |
| Gedeborg R and Wiklund L | Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. | 1998 Oct-Nov | Resuscitation | pmid:9918458 |
| Stafforini DM and Tjoelker LW | Human plasma platelet-activating factor acetylhydrolase. | 1999 | Methods Mol. Biol. | pmid:9918011 |
| Siddiqui RA et al. | Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes. | 1999 | J. Immunol. | pmid:9916736 |
| Zhang Y et al. | RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. | 1999 | J. Biol. Chem. | pmid:9915820 |
| Qu XW et al. | The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. | 1999 | Gut | pmid:9895379 |