Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Acute Kidney Injury D058186 34 associated lipids
Acute Lung Injury D055371 33 associated lipids
Mucositis D052016 7 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Hyperuricemia D033461 4 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Stenosis D023921 6 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Fetal Weight D020567 12 associated lipids
Stroke D020521 32 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Migraine without Aura D020326 1 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Venous Thrombosis D020246 11 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Thrombophilia D019851 6 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Leukostasis D018921 1 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Pelvic Pain D017699 7 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Liver Failure D017093 5 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Drapier JC et al. Lipid-mediator synthesis in peritoneal macrophages from mice injected with immunostimulants. 1983 Biochim. Biophys. Acta pmid:6131693
Otsuka A et al. alpha-Adrenergic blocking action of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats. 1983 Clin Exp Hypertens A pmid:6133661
Haddad ZH and Green A State--and dynamics--of the art: a current review. IgE-mediated immediate hypersensitivity reactions: cellular events and pharmacologic mediators. 1983 J Asthma pmid:6190793
Cargill DI et al. Aggregation, release and desensitization induced in platelets from five species by platelet activating factor (PAF). 1983 Thromb. Haemost. pmid:6879508
Machin SJ et al. Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder. 1983 J. Clin. Pathol. pmid:6413552
Alam I et al. Metabolism of platelet-activating factor by blood platelets and plasma. 1983 Lipids pmid:6413803
Pinckard RN Platelet-activating factor. 1983 Hosp. Pract. (Off. Ed.) pmid:6414941
Camussi G et al. The release of platelet-activating factor from human endothelial cells in culture. 1983 J. Immunol. pmid:6415166
Lin AH et al. Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. 1982 J. Clin. Invest. pmid:6290535
Vargaftig BB et al. Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. 1982 Thromb. Res. pmid:7164036
Long MW et al. Immature megakaryocytes in the mouse: physical characteristics, cell cycle status, and in vitro responsiveness to thrombopoietic stimulatory factor. 1982 Blood pmid:7059669
Humphrey DM et al. Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues. 1982 Lab. Invest. pmid:7070056
Gimbrone MA Blood vessels and the new mediators of inflammation. 1982 Lab. Invest. pmid:7070058
Mencia-Huerta JM et al. Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. 1982 J. Immunol. pmid:7086143
Prancan A et al. Relaxation of the guinea-pig trachea induced by platelet-activating factor and by serotonin. 1982 Eur. J. Pharmacol. pmid:7095003
Humphrey DM et al. Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine. 1982 Lab. Invest. pmid:7109542
Karpatkin S et al. Platelet aggregating material (PAM) of two virally-transformed tumors: SV3T3 mouse fibroblast and PW20 rat renal sarcoma. Role of cell surface sialylation. 1982 Prog. Clin. Biol. Res. pmid:7111309
Voelkel NF et al. Nonimmunological production of leukotrienes induced by platelet-activating factor. 1982 Science pmid:7123233
Kelly GL and Eiseman B Development of a new vascular prosthetic: lessons learned. 1982 Arch Surg pmid:7125901
Sugiura T et al. Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. 1982 Biochim. Biophys. Acta pmid:7126622
Vargaftig BB et al. Non-steroidal anti-inflammatory drugs if combined with anti-histamine and anti-serotonin agents interfere with the bronchial and platelet effects of "platelet-activating factor" (PAF-acether). 1982 Eur. J. Pharmacol. pmid:7128682
Namm DH et al. Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine. 1982 Thromb. Res. pmid:7071810
Keraly CL and Benveniste J Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives. 1982 Br. J. Haematol. pmid:7082588
Wykle RL et al. Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. 1982 FEBS Lett. pmid:7084476
Sánchez-Crespo M et al. Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. 1982 Immunopharmacology pmid:7085259
Mueller HW et al. Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. 1982 Lipids pmid:7087685
Page CP et al. Platelet activation in asthma. 1982 N. Engl. J. Med. pmid:7088080
Lefort J et al. Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. 1982 Agents Actions pmid:7164948
Roubin R et al. Release of platelet-activating factor (PAF-acether) and leukotrienes C and D from inflammatory macrophages. 1982 Eur. J. Immunol. pmid:6122581
Lanara E et al. Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. 1982 Biochem. Biophys. Res. Commun. pmid:7168759
O'Flaherty JT Lipid mediators of inflammation and allergy. 1982 Lab. Invest. pmid:6126615
Sánchez-Crespo M et al. Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. 1982 Clin. Exp. Immunol. pmid:7172498
Pinckard RN The "new" chemical mediators of inflammation. 1982 Monogr Pathol pmid:6126808
Ieyasu H et al. A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. 1982 Biochem. Biophys. Res. Commun. pmid:7181916
Camussi G et al. The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes. 1982 Adv. Exp. Med. Biol. pmid:7090917
Robeva R et al. [Changes in blood coagulation in glomerulonephritis]. 1982 Vutr Boles pmid:6219496
Ingraham LM et al. Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. 1982 Blood pmid:6282362
Valone FH et al. Specific binding of phospholipid platelet-activating factor by human platelets. 1982 J. Immunol. pmid:6286773
Lüscher EF The role of blood cells and of the vessel wall in the induction of intravascular coagulation. 1982 Klin. Wochenschr. pmid:6750223
Czarneztki BM Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release. 1982 Chem. Phys. Lipids pmid:6814773
Basran GS et al. Cromoglycate (DSCG) inhibits responses to platelet-activating factor (PAF-acether) in man: an alternative mode of action for DSCG in asthma? 1982 Eur. J. Pharmacol. pmid:6819153
Chesney CM et al. Effect of platelet-activating factor (PAF) on human platelets. 1982 Blood pmid:7037068
Masugi F et al. [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. 1982 Tanpakushitsu Kakusan Koso pmid:6758041
Modiano A and Belisario A [Recent information on PAF (Platelet Activating Factor) in hemocoagulative and immuno-allergic processes]. 1982 G Clin Med pmid:6762313
Marcus AJ et al. Arachidonic acid metabolism in endothelial cells and platelets. 1982 Ann. N. Y. Acad. Sci. pmid:6762834
Masugi F et al. Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. 1982 Biochem. Biophys. Res. Commun. pmid:7041899
Lapetina EG Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. 1982 J. Biol. Chem. pmid:7045103
Jouvin-Marche E et al. Platelet-activating factor (PAF-acether), an activator of neutrophil functions. 1982 Agents Actions pmid:6299078
Caillard CG et al. Hypotensive activity of PAF-acether in rats. 1982 Agents Actions pmid:6299079
Hartung HP et al. Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). 1982 Agents Actions Suppl. pmid:6960648