Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nathan N et al. | Effects of the platelet-activating factor receptor antagonist BN 52021 on hematologic variables and blood loss during and after cardiopulmonary bypass. | 1994 | Anesth. Analg. | pmid:7639352 |
| Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
| Despotis GJ et al. | Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. | 1996 | Anesthesiology | pmid:8968178 |
| Pierce PA et al. | Halothane selectively inhibits bradykinin-induced synovial plasma extravasation. | 1995 | Anesthesiology | pmid:7661358 |
| Strümper D et al. | Effects of antidepressants on function and viability of human neutrophils. | 2003 | Anesthesiology | pmid:12766643 |
| Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
| Hofer RE et al. | The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. | 1993 | Anesthesiology | pmid:8342844 |
| Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
| Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
| Kudriavtseva IuA et al. | [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. | 2008 | Angiol Sosud Khir | pmid:19156039 |
| Tsantila N et al. | In vitro and in vivo effects of statins on platelet-activating factor and its metabolism. | 2011 | Angiology | pmid:20805097 |
| Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
| Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |
| Gupta JB et al. | Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | 1994 | Angiology | pmid:8285381 |
| Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
| Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
| Page C | Asthma as a chronic inflammatory disease and the implications for future therapy. | 1992 | Ann Allergy | pmid:1355953 |
| Wang S and Townley RG | Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. | 1992 | Ann Allergy | pmid:1324627 |
| Eda R et al. | Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide. | 1994 | Ann Allergy | pmid:8067599 |
| Miyagawa H et al. | Variations in chemotaxis and chemokinesis of neutrophils of different densities from patients with allergic rhinitis. | 1991 | Ann Allergy | pmid:1958006 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| Miyagawa H et al. | Density change of neutrophils from allergic subjects by granulocyte-macrophage colony stimulating factor. | 1993 | Ann Allergy | pmid:8214805 |
| Rothenberger DA and Wiltz O | [Etiology of "pouchitis"]. | 1993 | Ann Chir | pmid:8161133 |
| Lugrin D et al. | [Thrombocytopenia induced by heparin and cardiac surgery with extracorporeal circulation]. | 1990 | Ann Fr Anesth Reanim | pmid:2400150 |
| Doly M and Oustrin J | [Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors]. | 1996 | Ann Pharm Fr | pmid:8734330 |
| Shindo K | Inhibitory effect of azelastine on platelet activating factor-like activity in eosinophils in asthmatic patients. | 1995 | Ann Pharmacother | pmid:7606085 |
| González-Fajardo JA et al. | Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure. | 1996 | Ann Vasc Surg | pmid:8688291 |
| Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |
| Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
| Tokuyama K et al. | Effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing response caused by inflammatory mediators in asthmatic children. | 1995 | Ann. Allergy Asthma Immunol. | pmid:7544228 |
| Chihara J et al. | Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). | 1998 | Ann. Allergy Asthma Immunol. | pmid:9860039 |
| Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
| Seguchi M and Nakajima S | Induction of ICAM-1 expression on the eosinophilic leukemia cell line-3 (EoL-3) by platelet-activating factor and platelet factor 4. | 1995 | Ann. Allergy Asthma Immunol. | pmid:7889382 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Vadas P | The platelet-activating factor pathway in food allergy and anaphylaxis. | 2016 | Ann. Allergy Asthma Immunol. | pmid:27788869 |
| Metz M et al. | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. | 2010 | Ann. Allergy Asthma Immunol. | pmid:20143651 |
| Hemmendinger S et al. | [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. | 1986 | Ann. Biol. Clin. (Paris) | pmid:3538949 |
| Godard P et al. | [Physiopathology of asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675684 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Grino JM | BN 52021: a platelet activating factor antagonist for preventing post-transplant renal failure. A double-blind, randomized study. The BN 52021 Study Group in Renal Transplantation. | 1994 | Ann. Intern. Med. | pmid:8042824 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
| Atkins JN | Platelet-aggregating factor in thrombotic thrombocytopenic purpura. | 1985 | Ann. Intern. Med. | pmid:4038861 |
| Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
| He J et al. | Micellar electrokinetic capillary chromatographic analysis of platelet activating factor in human blood by indirect ultraviolet detection. | 1996 | Ann. Ist. Super. Sanita | pmid:9028060 |
| Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
| Barnes PJ | Platelet activating factor and asthma. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659278 |
| Hwang SB | Function and regulation of extracellular and intracellular receptors of platelet activating factor. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659279 |
| O'Donnell M | Effects of Ro 24-4736 in antagonizing the platelet and bronchoconstrictor responses to PAF. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659287 |
| Dray F et al. | Prostaglandin E2, leukotriene C4, and platelet-activating factor receptor sites in the brain. Binding parameters and pharmacological studies. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2549827 |
| Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
| Thivierge M and Rola-Pleszczynski M | Involvement of both cyclooxygenase and lipoxygenase pathways in platelet-activating factor-induced interleukin-6 production by alveolar macrophages. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030993 |
| Tamura K et al. | The effects of platelet activating factor antagonist, TCV309, on the relationship between electrophysiological and mechanical status during myocardial ischemia and reperfusion. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030887 |
| Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
| Rabinovici R et al. | Cytokine gene and peptide regulation in lung microvascular injury: new insights on the development of adult respiratory distress syndrome. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031006 |
| Neville LF et al. | Application of differential display to isolate novel genes in interleukin-2-induced adult respiratory distress syndrome. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906233 |
| Asmis R and Dennis EA | Regulation of prostaglandin E2 production in P388D1 macrophage-like cells. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825831 |
| Welton AF et al. | Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825850 |
| Snyder F et al. | Platelet-activating factor and related ether lipid mediators. Biological activities, metabolism, and regulation. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2698076 |
| Bito H et al. | Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:9137600 |
| Panetta T et al. | Arachidonic acid metabolism and cerebral blood flow in the normal, ischemic, and reperfused gerbil brain. Inhibition of ischemia-reperfusion-induced cerebral injury by a platelet-activating factor antagonist (BN 52021). | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774404 |
| Powell DW | Epithelial secretory responses to inflammation. Platelet activating factor and reactive oxygen metabolites. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456654 |
| Willard AL | Excitatory and neurotoxic actions of platelet-activating factor on rat myenteric neurons in cell culture. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456659 |
| Mullane KM et al. | Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837948 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Braquet P et al. | The role of platelet-activating factor in cerebral ischemia and related disorders. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2672941 |
| Klöcking HP | Inhibition of PAF-induced tPA release by KO-286011. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1309038 |
| Onorato JM et al. | Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928437 |
| O'Neill C et al. | Embryo-derived platelet-activating factor. Its diagnostic and therapeutic future. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3195924 |
| Snyder F et al. | Metabolism of platelet activating factor in lung. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952548 |
| Krell RD and McCarthy M | Pharmacologic analysis of platelet activating factor16- and 18-induced bronchoconstriction in the guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952549 |
| Gundel RH et al. | The role of platelet activating factor in airway inflammation, airway hyperresponsiveness, and pulmonary function in monkeys. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952550 |
| Burrows LJ et al. | Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952566 |
| Spencer DA et al. | The effects of a 5-lipoxygenase inhibitor, BW A4C, on the acute response to inhaled PAF in man. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952568 |
| Boulay F et al. | Phagocyte chemoattractant receptors. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9704038 |
| Schröder JM et al. | RANTES, a novel eosinophil-chemotactic cytokine. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518215 |
| Nakamura T et al. | Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8363265 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Tuomanen EI | Molecular and cellular mechanisms of pneumococcal meningitis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993350 |
| Marcus AJ et al. | Arachidonic acid metabolism in endothelial cells and platelets. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6762834 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Vargaftig BB et al. | Background and present status of research on platelet-activating factor (PAF-acether). | 1981 | Ann. N. Y. Acad. Sci. | pmid:7023317 |
| Coëffier E et al. | Modulation of the enhanced migration of eosinophils from the airways of sensitized guinea pigs: role of IL-5. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030999 |
| Karpatkin S et al. | Role of platelets in tumor cell metastases. | 1981 | Ann. N. Y. Acad. Sci. | pmid:6943955 |
| Piper PJ et al. | Release of leukotrienes from porcine and human blood vessels by immunological and nonimmunological stimuli. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837950 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Lindsberg PJ et al. | Platelet-activating factor in stroke and brain injury. | 1991 | Ann. Neurol. | pmid:1897906 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Rhee CK et al. | Effects of platelet activating factor on vascular permeability of the middle ear mucosa. | 1997 | Ann. Otol. Rhinol. Laryngol. | pmid:9228864 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
| Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |