Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |
| Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
| Torley LW et al. | Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. | 1992 | Antimicrob. Agents Chemother. | pmid:1416889 |
| Joseph S and MacDermot J | Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization. | 1992 | Biochem. J. | pmid:1417754 |
| Chuvilin AN et al. | [Synthesis of phosphono analogs of a phospholipid platelet activating factor]. | 1992 | Bioorg. Khim. | pmid:1418000 |
| Muacevic G and Heuer HO | Platelet-activating factor antagonists in experimental shock. | 1992 | Arzneimittelforschung | pmid:1418068 |
| Mügge A et al. | Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo. | 1992 | Atherosclerosis | pmid:1418094 |
| Blank M et al. | Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype. | 1992 | J. Autoimmun. | pmid:1418290 |
| Samet JM et al. | Effect of ozone on platelet-activating factor production in phorbol-differentiated HL60 cells, a human bronchial epithelial cell line (BEAS S6), and primary human bronchial epithelial cells. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1419027 |
| Tsuruta S et al. | Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors. | 1992 | Cell. Signal. | pmid:1419490 |
| Caplan MS et al. | Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells. | 1992 | Biochim. Biophys. Acta | pmid:1420292 |
| Kulikov VI and Muzia GI | [Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators]. | 1992 | Biokhimiia | pmid:1420585 |
| e Silva PM et al. | Pharmacological modulation of the late eosinophilia induced by antigen in actively sensitized rats. | 1992 | Int. Arch. Allergy Immunol. | pmid:1422263 |
| Takada Y et al. | Protective effect of platelet-activating factor antagonist on hepatic energy metabolism following transient hepatic inflow occlusion in rabbits. | 1992 | Circ. Shock | pmid:1423921 |
| Dreyer WJ et al. | Kinetics of C5a release in cardiac lymph of dogs experiencing coronary artery ischemia-reperfusion injury. | 1992 | Circ. Res. | pmid:1423944 |
| Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
| Kroegel C | Does airway smooth muscle care about platelet-activating factor? | 1992 | Eur. Respir. J. | pmid:1426197 |
| Johnson PR et al. | Platelet-activating factor-induced contraction of human isolated bronchus. | 1992 | Eur. Respir. J. | pmid:1426205 |
| Adamson LM et al. | Loss of PAF-like activity from human embryo conditioned media (ECM) following HPLC separation. | 1992 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:1426496 |
| López Bernal A et al. | Platelet-activating factor levels in human follicular and amniotic fluids. | 1992 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:1426500 |
| Remé C et al. | Light and lithium effects in the rat retina: modification by the PAF antagonist BN 52021. | 1992 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:1427144 |
| Sobhani I et al. | Raised concentrations of platelet activating factor in colonic mucosa of Crohn's disease patients. | 1992 | Gut | pmid:1427375 |
| Zhou W et al. | Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. | 1992 | Hepatology | pmid:1427662 |
| Holland MR et al. | Activation of the acetyl-coenzyme A:lysoplatelet-activating factor acetyltransferase regulates platelet-activating factor synthesis in human endothelial cells. | 1992 | J. Biol. Chem. | pmid:1429636 |
| Calderón E and Lockey RF | A possible role for adhesion molecules in asthma. | 1992 | J. Allergy Clin. Immunol. | pmid:1430710 |
| Blom M et al. | Priming of human eosinophils by platelet-activating factor enhances the number of cells able to bind and respond to opsonized particles. | 1992 | J. Immunol. | pmid:1431137 |
| Heller R et al. | Human endothelial cells are target for platelet-activating factor. II. Platelet-activating factor induces platelet-activating factor synthesis in human umbilical vein endothelial cells. | 1992 | J. Immunol. | pmid:1431139 |
| Bozza PT et al. | Increase in the rat blood leukocyte counts induced by PAF-acether is suppressed by general anesthesia. | 1992 | J. Leukoc. Biol. | pmid:1431550 |
| Kunievsky B and Yavin E | Platelet-activating factor stimulates arachidonic acid release and enhances thromboxane B2 production in intact fetal rat brain ex vivo. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1432689 |
| Wells XE and O'Neill C | Biosynthesis of platelet-activating factor by two-cell mouse embryos. | 1992 | J. Reprod. Fertil. | pmid:1432975 |
| Carceller E et al. | (Pyridylcyanomethyl)piperazines as orally active PAF antagonists. | 1992 | J. Med. Chem. | pmid:1433215 |
| Tuominen M et al. | Effects of Calaguala and an active principle, adenosine, on platelet activating factor. | 1992 | Planta Med. | pmid:1438589 |
| O'Neill C | Embryo-derived platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1438959 |
| Brochet B et al. | [Pilot study of Ginkgolide B, a PAF-acether specific inhibitor in the treatment of acute outbreaks of multiple sclerosis]. | 1992 | Rev. Neurol. (Paris) | pmid:1439458 |
| Suttorp N et al. | Stimulation of PAF-synthesis in pulmonary artery endothelial cells by Staphylococcus aureus alpha-toxin. | 1992 | Thromb. Res. | pmid:1440526 |
| Samet JM and Friedman M | Effect of ozone on platelet activating factor metabolism in phorbol-differentiated HL60 cells. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1440609 |
| Yara A et al. | Cardiovascular effects of Acanthaster planci venom in the rat: possible involvement of PAF in its hypotensive effect. | 1992 | Toxicon | pmid:1440631 |
| Sirén AL et al. | Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. | 1992 | Stroke | pmid:1440713 |
| Minami T et al. | Effects of various inflammatory mediators on eustachian tube patency. | 1992 | Acta Otolaryngol. | pmid:1442015 |
| Zhou W et al. | Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. | 1992 | Am. J. Physiol. | pmid:1443133 |
| Hayashi M et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445360 |
| Terashita Z et al. | Pharmacological profile of TCV-309--a potent PAF antagonist. | 1992 Jun-Jul | J Lipid Mediat | pmid:1445598 |
| Prokudin VIu et al. | [Modulating effects of adenosine on the process of human platelet activation]. | 1992 | Biull Eksp Biol Med | pmid:1446028 |
| Lin CN et al. | Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones. | 1992 | J Pharm Sci | pmid:1447715 |
| Makino S | [Features and treatment of immediate and late asthmatic responses]. | 1992 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1447838 |
| Winkler JD et al. | Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils. | 1992 | Biochem. Pharmacol. | pmid:1449523 |
| Favre E et al. | Structure-activity relationships in platelet-activating factor (PAF antagonists). 6. Synthesis and in vitro antagonistic activities of 2-substituted 5-oxotetrahydrofurans. | 1992 | J Lipid Mediat | pmid:1449553 |
| Lukashova V et al. | Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. | 2003 | J. Immunol. | pmid:14500680 |
| Morris C et al. | Transfer and metabolism of platelet-activating factor by fetal membranes, amnion and chorio-decidua. | 1992 | Br J Obstet Gynaecol | pmid:1450138 |
| Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
| Antonopoulou S et al. | Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. | 2003 | Mediators Inflamm. | pmid:14514473 |
| Schmidt J et al. | [Lack of stimulation of CD11b/CD18 induced leukocyte adhesioin by platelet activating factor (PAF) and f-MLP in malignant tumor endothelium in experimental pancreas cancer of the rat]. | 1998 | Langenbecks Arch Chir Suppl Kongressbd | pmid:14518288 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
| Biancone L et al. | Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. | 2003 | Clin. Cancer Res. | pmid:14519648 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Ahlemeyer B and Krieglstein J | Neuroprotective effects of Ginkgo biloba extract. | 2003 | Cell. Mol. Life Sci. | pmid:14523543 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Estellés R et al. | Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2003 | Br. J. Pharmacol. | pmid:14559857 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Miyagawa H et al. | The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils. | 1992 | Agents Actions | pmid:1456179 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Ivanov AI et al. | Platelet-activating factor: a previously unrecognized mediator of fever. | 2003 | J. Physiol. (Lond.) | pmid:14565987 |
| Powell DW | Epithelial secretory responses to inflammation. Platelet activating factor and reactive oxygen metabolites. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456654 |
| Willard AL | Excitatory and neurotoxic actions of platelet-activating factor on rat myenteric neurons in cell culture. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456659 |
| Zhang X et al. | Age-related increase of plasma platelet-activating factor concentrations in Chinese. | 2003 | Clin. Chim. Acta | pmid:14568193 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Taniguchi S et al. | Effects of double-filtration plasmapheresis and a platelet-activating factor antagonist on the prolongation of xenograft survival. | 1992 Nov-Dec | J. Heart Lung Transplant. | pmid:1457447 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Kogure K et al. | Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. | 2003 | Chem. Phys. Lipids | pmid:14580708 |
| Shankar G and Stern PH | Interactions of tumor necrosis factor with local and systemic factors in fetal rat limb bones. | 1992 | Calcif. Tissue Int. | pmid:1458343 |
| Wang Y et al. | Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta. | 2004 | J. Cell. Physiol. | pmid:14584044 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Chlopicki S et al. | Obligatory role of lipid mediators in platelet-neutrophil adhesion. | 2003 | Thromb. Res. | pmid:14592550 |
| Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
| Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
| Leonhardt U et al. | Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models. | 1992 | Int. J. Pancreatol. | pmid:1460331 |
| Russo S et al. | Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. | 2003 | J. Immunol. | pmid:14607955 |
| Slomiany BL and Slomiany A | Biphasic role of platelet-activating factor in oral mucosal ulcer healing. | 2003 | IUBMB Life | pmid:14609204 |
| Collado MP et al. | Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. | 2003 | Microvasc. Res. | pmid:14609525 |
| Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
| Gödecke A | PAF, PIP(3) and NO: emerging role in reperfusion injury. | 2003 | Cardiovasc. Res. | pmid:14613846 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. | 2003 | Cardiovasc. Res. | pmid:14613853 |
| Akisu M et al. | Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. | 2003 | Eur J Pediatr Surg | pmid:14618522 |
| Ichimaru T and Tai HH | Alteration of platelet activating factor (PAF) metabolism in rat pulmonary alveolar macrophages and plasma by cigarette smoking. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1461922 |
| Ryan JP et al. | Metabolic and developmental responses of preimplantation embryos to platelet activating factor (PAF). | 1992 | Reprod. Fertil. Dev. | pmid:1461990 |
| Pike IL et al. | Actions of platelet activating factor (PAF) on gametes and embryos: clinical aspects. | 1992 | Reprod. Fertil. Dev. | pmid:1461991 |
| Kroegel C et al. | Cytokines, platelet activating factor and eosinophils in asthma. | 1992 | Respir Med | pmid:1462017 |
| Hirt SW et al. | Antagonisation of platelet activating factor--a new therapeutic concept for improvement of organ quality in lung preservation. | 1992 | Transpl. Int. | pmid:14621825 |
| Willoughby S et al. | Platelets and cardiovascular disease. | 2002 | Eur J Cardiovasc Nurs | pmid:14622657 |
| Montero M et al. | Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator. | 1992 | Biochem. J. | pmid:1463455 |
| De Vriese AS and Bourgeois M | Pharmacologic treatment of acute renal failure in sepsis. | 2003 | Curr Opin Crit Care | pmid:14639066 |
| Kobayashi S et al. | Molecular design of biologically active compounds based on platelet activating factor (PAF): 7-oxabicyclo[2.2.1]heptane system as a strong antagonist of PAF. | 1992 | Chem. Pharm. Bull. | pmid:1464124 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Amer MD et al. | Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. | 2004 | Biol. Neonate | pmid:14646336 |
| Cole KP and Hsung RP | Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. | 2003 | Org. Lett. | pmid:14653688 |
| Lekka ME et al. | The impact of intravenous fat emulsion administration in acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14656749 |
| Brandt EB et al. | Mast cells are required for experimental oral allergen-induced diarrhea. | 2003 | J. Clin. Invest. | pmid:14660743 |