Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Igarashi Y | [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. | 1997 | Seikagaku | pmid:9431007 |
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| Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
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| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
| Wang R et al. | [High performance thin layer chromatographic (HPTLC) determination of PAF in cerebrospinal fluid of patients with subarachnoid hemorrhage(SAH)]. | 1999 | Se Pu | pmid:12552702 |
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| Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
| Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
| Abisogun AO et al. | The involvement of platelet activating factor in ovulation. | 1989 | Science | pmid:2911750 |
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| Teruel MN and Meyer T | Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. | 2002 | Science | pmid:11884760 |
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| Geffner JR et al. | Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes. | 1991 | Scand. J. Immunol. | pmid:1903211 |
| Morita E et al. | Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. | 1989 | Scand. J. Immunol. | pmid:2544988 |
| Renkonen R et al. | Lymphocyte binding to and penetration through vascular endothelium is stimulated by platelet-activating factor. | 1989 | Scand. J. Immunol. | pmid:2602912 |
| Lindström P et al. | Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. | 1990 | Scand. J. Immunol. | pmid:1972589 |
| Yoshida N et al. | Pathogenesis of platelet-activating factor-induced gastric mucosal damage in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2556790 |
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| Iwai A et al. | Role of PAF in ischemia-reperfusion injury in the rat stomach. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595310 |
| Binnaka T et al. | Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595311 |
| Hatakeyama K et al. | Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595312 |
| Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
| Wang LS et al. | Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. | 2002 | Scand. J. Gastroenterol. | pmid:11989839 |
| Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Binnaka T et al. | Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor. | 1990 | Scand. J. Gastroenterol. | pmid:2359986 |
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| Kald B et al. | Phospholipase C from Clostridium perfringens stimulates acetyltransferase-dependent formation of platelet-activating factor in cultured intestinal epithelial cells (INT 407). | 1994 | Scand. J. Gastroenterol. | pmid:8209184 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
| Binnaka T et al. | Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor. | 1992 | Scand. J. Gastroenterol. | pmid:1561532 |
| Palmblad J et al. | Interactions between alkylglycerols and human neutrophil granulocytes. | 1990 | Scand. J. Clin. Lab. Invest. | pmid:2168089 |
| Jørgensen L et al. | Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8272758 |
| Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
| Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
| Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |