Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bottecchia D et al. | Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. | 1984 | Scand J Haematol | pmid:6695148 |
Rylander R | Role of endotoxin and glucan for the development of granulomatous disease in the lung. | 1989 | Sarcoidosis | pmid:2623374 |
Teles de Araújo A et al. | Surfactant modifications and lipidic mediators in occupational lung diseases. | 1989 | Sarcoidosis | pmid:2623375 |
Kaminker AJ and Carreras LO | [Physiopathology of thrombotic microangiopathy]. | 1989 | Sangre (Barc) | pmid:2667170 |
Rotllan E et al. | [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. | 1993 | Sangre (Barc) | pmid:8390724 |
Meloni Bruneri LH and Barbieri D | [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. | 1985 | Sangre (Barc) | pmid:4071355 |
Zăgrean L et al. | Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats. | 1998 Jan-Jun | Rom J Physiol | pmid:11000876 |
Debek W et al. | Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528982 |
Kirejczyk JK et al. | Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528996 |
Kirejczyk JK et al. | Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528997 |
Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |
Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
Izumi T and Shimizu T | [Biological regulation with platelet activating factor--molecular cloning and signal transduction of PAF]. | 1994 | Rinsho Ketsueki | pmid:8028185 |
Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
Oda M et al. | [Platelet-activating factor producing cell--target cell interactions]. | 1989 | Rinsho Byori | pmid:2754814 |
Oura Y | [The effects of platelet-activating factor (PAF) on the collagen-induced whole blood aggregation]. | 1994 | Rinsho Byori | pmid:8107285 |
Maki N et al. | [Analysis of platelet-activating factor and its effect on the lung]. | 1993 | Rinsho Byori | pmid:8361018 |
Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
Ganbo T et al. | Platelet activating factor (PAF) effects on ciliary activity of human paranasal sinus mucosa in vitro. | 1991 | Rhinology | pmid:1947682 |
Ganbo T et al. | Turn-over of PAF in cultures of human paranasal sinus mucosa. | 1994 | Rhinology | pmid:7839082 |
Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
Sperling RI | Dietary omega-3 fatty acids: effects on lipid mediators of inflammation and rheumatoid arthritis. | 1991 | Rheum. Dis. Clin. North Am. | pmid:1862246 |
Simmet T and Peskar BA | Eicosanoids and the coronary circulation. | 1986 | Rev. Physiol. Biochem. Pharmacol. | pmid:3520775 |
Brochet B et al. | [Pilot study of Ginkgolide B, a PAF-acether specific inhibitor in the treatment of acute outbreaks of multiple sclerosis]. | 1992 | Rev. Neurol. (Paris) | pmid:1439458 |
Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
Charbonneau P and Suisse A | [Syndrome of multiple organ failure]. | 1990 | Rev Prat | pmid:2263856 |
Massion PB and Frans A | [Role of platelet activating factor and its antagonists in bronchial asthma]. | 1992 | Rev Pneumol Clin | pmid:1384101 |
Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
Leclercq M et al. | [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. | 1985 | Rev Med Liege | pmid:2418479 |
Nechifor M | [Agonists and antagonists of the platelet activating factor (PAF)]. | 1989 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:2636782 |
Cijevschi I and Cijevschi D | [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. | 1999 Jan-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:10756889 |
Nechifor M | [Agonists and antagonists of the platelet activating factor (PAF). II]. | 1990 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:2100870 |
Martin JG | [Animal models of bronchial hyperreactivity]. | 1994 | Rev Mal Respir | pmid:7515508 |
Ais JG et al. | [The physiopathology of acute pancreatitis: the role of platelet-activating factor (PAF)]. | 1992 | Rev Esp Enferm Dig | pmid:1547030 |
Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
Egido J et al. | [The participation of platelet-activating factor and cytokines in the pathogenesis of glomerular damage]. | 1990 Jul-Aug | Rev Clin Esp | pmid:2284487 |
Hosford D et al. | Platelet-activating factor and cytokine interactions in shock. | 1989 | Resuscitation | pmid:2555874 |
Gedeborg R and Wiklund L | Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. | 1998 Oct-Nov | Resuscitation | pmid:9918458 |
Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
Ruchaud-Sparagano MH et al. | Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. | 2013 | Respirology | pmid:23730995 |
Gebremichael I and Leuenberger P | Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects. | 1992 | Respiration | pmid:1485002 |
Block LH et al. | PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals. | 1990 | Respiration | pmid:2099571 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |