Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Bottecchia D et al. Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. 1984 Scand J Haematol pmid:6695148
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Teles de Araújo A et al. Surfactant modifications and lipidic mediators in occupational lung diseases. 1989 Sarcoidosis pmid:2623375
Kaminker AJ and Carreras LO [Physiopathology of thrombotic microangiopathy]. 1989 Sangre (Barc) pmid:2667170
Rotllan E et al. [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. 1993 Sangre (Barc) pmid:8390724
Meloni Bruneri LH and Barbieri D [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. 1985 Sangre (Barc) pmid:4071355
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Debek W et al. Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. 1995 Rocz. Akad. Med. Bialymst. pmid:8528982
Kirejczyk JK et al. Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. 1995 Rocz. Akad. Med. Bialymst. pmid:8528996
Kirejczyk JK et al. Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021. 1995 Rocz. Akad. Med. Bialymst. pmid:8528997
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Nagata K et al. [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. 1984 Rinsho Ketsueki pmid:6542941
Asada Y [Inflammatory and immune responses in arterial thrombus formation]. 2005 Rinsho Ketsueki pmid:16447700
Takahashi H et al. [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. 1987 Rinsho Byori pmid:3501812
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Oura Y [The effects of platelet-activating factor (PAF) on the collagen-induced whole blood aggregation]. 1994 Rinsho Byori pmid:8107285
Maki N et al. [Analysis of platelet-activating factor and its effect on the lung]. 1993 Rinsho Byori pmid:8361018
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Kawamura Y et al. [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. 1987 Rinsho Byori pmid:3437547
Ganbo T et al. Platelet activating factor (PAF) effects on ciliary activity of human paranasal sinus mucosa in vitro. 1991 Rhinology pmid:1947682
Ganbo T et al. Turn-over of PAF in cultures of human paranasal sinus mucosa. 1994 Rhinology pmid:7839082
Lima MC et al. Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. 1988 Rhinol. Suppl. pmid:2907679
Su J et al. Natural antibodies against phosphorylcholine as potential protective factors in SLE. 2008 Rheumatology (Oxford) pmid:18522961
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Simmet T and Peskar BA Eicosanoids and the coronary circulation. 1986 Rev. Physiol. Biochem. Pharmacol. pmid:3520775
Brochet B et al. [Pilot study of Ginkgolide B, a PAF-acether specific inhibitor in the treatment of acute outbreaks of multiple sclerosis]. 1992 Rev. Neurol. (Paris) pmid:1439458
Romero A et al. [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. 1988 Rev. Esp. Fisiol. pmid:3072620
Santos JC et al. Effect of intrarenal infusion of synthetic PAF-acether in dogs. 1988 Rev. Esp. Fisiol. pmid:3231880
Charbonneau P and Suisse A [Syndrome of multiple organ failure]. 1990 Rev Prat pmid:2263856
Massion PB and Frans A [Role of platelet activating factor and its antagonists in bronchial asthma]. 1992 Rev Pneumol Clin pmid:1384101
Santos OF et al. [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. 1988 Jul-Aug Rev Paul Med pmid:3076976
Leclercq M et al. [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. 1985 Rev Med Liege pmid:2418479
Nechifor M [Agonists and antagonists of the platelet activating factor (PAF)]. 1989 Oct-Dec Rev Med Chir Soc Med Nat Iasi pmid:2636782
Cijevschi I and Cijevschi D [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. 1999 Jan-Jun Rev Med Chir Soc Med Nat Iasi pmid:10756889
Nechifor M [Agonists and antagonists of the platelet activating factor (PAF). II]. 1990 Apr-Jun Rev Med Chir Soc Med Nat Iasi pmid:2100870
Martin JG [Animal models of bronchial hyperreactivity]. 1994 Rev Mal Respir pmid:7515508
Ais JG et al. [The physiopathology of acute pancreatitis: the role of platelet-activating factor (PAF)]. 1992 Rev Esp Enferm Dig pmid:1547030
Fité-Mora R Torsade de pointes associated with rupatadine. 2009 Rev Esp Cardiol pmid:19268083
Egido J et al. [The participation of platelet-activating factor and cytokines in the pathogenesis of glomerular damage]. 1990 Jul-Aug Rev Clin Esp pmid:2284487
Hosford D et al. Platelet-activating factor and cytokine interactions in shock. 1989 Resuscitation pmid:2555874
Gedeborg R and Wiklund L Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. 1998 Oct-Nov Resuscitation pmid:9918458
Matheson MJ et al. Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. 1997 Respirology pmid:9424405
Li HP et al. Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. 1998 Respirology pmid:9692515
Ruchaud-Sparagano MH et al. Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. 2013 Respirology pmid:23730995
Gebremichael I and Leuenberger P Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects. 1992 Respiration pmid:1485002
Block LH et al. PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals. 1990 Respiration pmid:2099571
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734