Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Diez-Fraile A et al. Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. 2004 Am. J. Vet. Res. pmid:15524330
McClenahan DJ et al. Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. 2000 Am. J. Vet. Res. pmid:10714514
Menzies-Gow NJ et al. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. 2008 Am. J. Vet. Res. pmid:18241016
Wilson DV et al. Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies. 1994 Am. J. Vet. Res. pmid:8067617
Wilson DV et al. Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. 1993 Am. J. Vet. Res. pmid:8430938
Weiss DJ and Evanson OA Detection of activated platelets and platelet-leukocyte aggregates in horses. 1997 Am. J. Vet. Res. pmid:9256963
McClenahan DJ et al. In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. 2002 Am. J. Vet. Res. pmid:11911574
Wilson DV and Stick JA Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. 1993 Am. J. Vet. Res. pmid:8498751
Tan WC and Bethel RA The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. 1992 Am. Rev. Respir. Dis. pmid:1416419
Symposium on The Clinical Importance of Leukotrienes and Platelet-activating Factor in Allergic Respiratory Diseases. November 14, 1990, San Francisco, California. 1991 Am. Rev. Respir. Dis. pmid:1673326
Christman BW et al. Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep. 1990 Am. Rev. Respir. Dis. pmid:2174655
Kohrogi H et al. Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. 1991 Am. Rev. Respir. Dis. pmid:1892304
Thivierge M and Rola-Pleszczynski M Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. 1991 Am. Rev. Respir. Dis. pmid:1650153
Kaye MG and Smith LJ Effects of inhaled leukotriene D4 and platelet-activating factor on airway reactivity in normal subjects. 1990 Am. Rev. Respir. Dis. pmid:2183659
Hamasaki Y et al. Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. 1984 Am. Rev. Respir. Dis. pmid:6547031
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Boschetto P et al. Corticosteroid inhibition of airway microvascular leakage. 1991 Am. Rev. Respir. Dis. pmid:2001074
Burhop KE et al. Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. 1986 Am. Rev. Respir. Dis. pmid:3752711
Stengel PW et al. Inhaled A23187 produces a preferential sensitization to substance P. 1993 Am. Rev. Respir. Dis. pmid:7678372
Daniel EE and O'Byrne P Effect of inflammatory mediators on airway nerves and muscle. 1991 Am. Rev. Respir. Dis. pmid:2003686
Rylander R and Beijer L Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3541718
Perretti F and Manzini S Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs. 1993 Am. Rev. Respir. Dis. pmid:7692777
Henderson WR Eicosanoids and platelet-activating factor in allergic respiratory diseases. 1991 Am. Rev. Respir. Dis. pmid:1902069
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Christman BW et al. Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. 1987 Am. Rev. Respir. Dis. pmid:3592402
Benveniste J A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? 1987 Am. Rev. Respir. Dis. pmid:3592414
Halonen M et al. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. 1981 Am. Rev. Respir. Dis. pmid:7294504
Lohman I and Halonen M Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. 1990 Am. Rev. Respir. Dis. pmid:2382903
Stenmark KR et al. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. 1987 Am. Rev. Respir. Dis. pmid:3631747
Caplan MS et al. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. 1990 Am. Rev. Respir. Dis. pmid:2252241
Lien DC et al. Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. 1992 Am. Rev. Respir. Dis. pmid:1546852
Barer GR et al. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. 1989 Am. Rev. Respir. Dis. pmid:2817616
Brigham KL Conference summary: lipid mediators in the pulmonary circulation. 1987 Am. Rev. Respir. Dis. pmid:2820285
Pretolani M et al. Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. 1988 Am. Rev. Respir. Dis. pmid:3202509
Schellenberg RR Airway responses to platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3310779
Pretolani M et al. Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. 1990 Am. Rev. Respir. Dis. pmid:2160213
Rubin AH et al. The bronchoconstrictor properties of platelet-activating factor in humans. 1987 Am. Rev. Respir. Dis. pmid:3314611
Horvath CJ et al. Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. 1991 Am. Rev. Respir. Dis. pmid:1741548
Arnoux B et al. Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. 1988 Am. Rev. Respir. Dis. pmid:3354991
Zimmerman GA et al. Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. 1987 Am. Rev. Respir. Dis. pmid:3300444
Murphy RC and Clay KL Measurement of platelet-activating factor by physicochemical technique s. 1987 Am. Rev. Respir. Dis. pmid:3300445
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Scappaticci E et al. Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. 1992 Am. Rev. Respir. Dis. pmid:1336939
Tokuyama K et al. Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. 1991 Am. Rev. Respir. Dis. pmid:2048823
Boschetto P et al. Effect of antiasthma drugs on microvascular leakage in guinea pig airways. 1989 Am. Rev. Respir. Dis. pmid:2563319
Kidney JC et al. Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. 1993 Am. Rev. Respir. Dis. pmid:8420421
Lellouch-Tubiana A et al. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. 1988 Am. Rev. Respir. Dis. pmid:3281530
Kuitert LM et al. Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. 1993 Am. Rev. Respir. Dis. pmid:8420437
Gulbenkian AR et al. Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. 1990 Am. Rev. Respir. Dis. pmid:2117872
Tam FW et al. Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. 1992 Am. Rev. Respir. Dis. pmid:1416388