Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Leslie CC and Detty DM Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. 1986 Biochem. J. pmid:3098232
DeFeudis FV Studies on endothelium-dependent vasorelaxation. 1986 Gen. Pharmacol. pmid:3512363
Huang C et al. Polymorphic phase behavior of platelet-activating factor. 1986 Biophys. J. pmid:3697472
Wardlow ML et al. Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor. 1986 J. Immunol. pmid:3514760
Lad PM et al. A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis. 1986 FEBS Lett. pmid:3699167
Böhm R and Giessler AJ [Thrombocyte aggregation inhibitors. A new class of active substances]. 1986 Pharmazie pmid:3515372
Viero P et al. Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? 1986 Haemostasis pmid:3699584
Etienne A et al. In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. 1986 Agents Actions pmid:3515870
Wallace JL and Whittle BJ Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. 1986 Prostaglandins pmid:3726156
Touvay C et al. Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. 1986 Immunopharmacology pmid:3021651
Hattori Y and Levi R Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. 1986 J. Pharmacol. Exp. Ther. pmid:3012066
Yasuda K et al. Platelet-activating factor in normal rat uterus. 1986 Biochem. Biophys. Res. Commun. pmid:3753495
Muirhead EE et al. Renal medullary system of blood pressure control. 1986 J Hypertens Suppl pmid:3534182
Buxton DB et al. Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 Biochem. Pharmacol. pmid:3754140
Foegh ML et al. The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats. 1986 Pharmacol Res Commun pmid:3534895
Toyofuku T et al. Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. 1986 Prostaglandins pmid:3754344
O'Flaherty JT Age dependency of the inflammatory response. 1986 Lab. Invest. pmid:3537520
Touvay C et al. Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. 1986 Agents Actions pmid:3754380
Sybertz EJ et al. AGEPC, a vasodilator phospholipid with profound circulatory actions. 1986 Prog. Clin. Biol. Res. pmid:3538024
Brock TA and Gimbrone MA Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. 1986 Am. J. Physiol. pmid:3717361
Piéroni G and Hanahan DJ Effect of acetylglyceryl ether phosphocholine (platelet-activating factor) and thrombin on acylation of exogenous lysophosphoglycerides in rabbit platelets. 1986 Biochim. Biophys. Acta pmid:3719000
Porcellini G [Platelet-activating factor: a new biochemical and pharmacologic frontier]. 1986 Clin Ter pmid:3720244
Wallace JL and Whittle BJ Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. 1986 Eur. J. Pharmacol. pmid:3720841
Handley DA et al. Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. 1986 Immunopharmacology pmid:3733419
Flower RJ Background and discovery of lipocortins. 1986 Agents Actions pmid:2938452
Schneider E et al. Transbilayer reorientation of platelet-activating factor in the erythrocyte membrane. 1986 FEBS Lett. pmid:3956740
Thomas MJ et al. Desorption chemical ionization mass spectrometry of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines and analogues. 1986 J. Lipid Res. pmid:3958619
Stimler-Gerard NP Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung. 1986 J. Pharmacol. Exp. Ther. pmid:3958964
Wade PJ et al. Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. 1986 Thromb. Res. pmid:3961730
Cerletti C et al. Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. 1986 N. Engl. J. Med. pmid:3941724
Parente L et al. The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. 1986 Agents Actions pmid:3962774
Tarayre JP et al. Inflammatory action of PAF-acether in the rat pleural cavity. 1986 Agents Actions pmid:3962789
Blank ML et al. Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. 1986 Biochim. Biophys. Acta pmid:3707974
Tarayre JP et al. Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. 1986 Eur. J. Pharmacol. pmid:3755401
Hsueh W et al. Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. 1986 Am. J. Pathol. pmid:3080895
Darius H et al. Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. 1986 Science pmid:3082008
Kohayakawa M and Inoue K Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. 1986 Thromb. Res. pmid:3083530
Cuss FM et al. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. 1986 Lancet pmid:2873440
Montrucchio G et al. Intravascular release of platelet-activating factor during atrial pacing. 1986 Lancet pmid:2874319
Hackenthal E and Taugner R Hormonal signals and intracellular messengers for renin secretion. 1986 Mol. Cell. Endocrinol. pmid:2875004
Swingle KF and Reiter MJ Inhibition of Paf-acether-induced edema of the rat's paw. 1986 Agents Actions pmid:2875631
Homburger HA Diagnosis of allergy: in vitro testing. 1986 Crit Rev Clin Lab Sci pmid:2426037
Pécoud A and Frei PC [Developmental trends in allergologic-immunologic research]. 1986 Internist (Berl) pmid:2427469
Raphael GD and Metcalfe DD Mediators of airway inflammation. 1986 Eur J Respir Dis Suppl pmid:2429857
Mossmann H et al. Effect of platelet-activating factor on human polymorphonuclear leukocyte enhancement of chemiluminescence and antibody-dependent cellular cytotoxicity. 1986 J. Leukoc. Biol. pmid:3455715
Mehta J et al. Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. 1986 Prostaglandins Leukot Med pmid:3456620
Cox CP et al. An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs. 1986 Life Sci. pmid:3773648
Godfroid JJ et al. Synthesis of ether phospholipids. 1986 Pharmacol Res Commun pmid:3774838
PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. 1986 Pharmacol Res Commun pmid:3774839
Vilain B et al. Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. 1986 Pharmacol Res Commun pmid:3774840