Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Penna C et al. Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. 2009 Acta Physiol (Oxf) pmid:19432589
Lang F et al. Osmotic shock-induced suicidal death of erythrocytes. 2006 May-Jun Acta Physiol (Oxf) pmid:16734755
Kecskemeti V Electrophysiological effects of platelet-activating factor (PAF) in guinea-pig cardiac preparations. 1990 Acta Physiol Hung pmid:2371852
Balogh I et al. Cytochemical effects of biologically active substances on the heart muscle. 1990 Acta Physiol Hung pmid:2371866
Alving K et al. The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. 1991 Acta Physiol. Scand. pmid:1957709
Arner M and Högestätt ED Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries. 1991 Acta Physiol. Scand. pmid:1715111
Björk J et al. Paf-acether (platelet-activating factor) increases microvascular permeability and affects endothelium-granulocyte interaction in microvascular beds. 1983 Acta Physiol. Scand. pmid:6659994
Karlström G et al. Renal and circulatory effects of medullipin I, as studied in the in-vivo cross-circulated isolated kidney and intact Wistar-Kyoto (WKY) rat. 1989 Acta Physiol. Scand. pmid:2603751
Iversen VV et al. Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. 2005 Acta Physiol. Scand. pmid:16128692
Greiff L et al. Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. 1997 Acta Physiol. Scand. pmid:9338520
Zia-ul-Haq M et al. Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. 2012 Jul-Aug Acta Pol Pharm pmid:22876614
Rubio de Krömer MT et al. Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. 1995 Acta Trop. pmid:8546035
Konstantinov SM et al. Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. 1997 Acta Trop. pmid:9107362
Dutra PM et al. Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). 2009 Acta Trop. pmid:19433049
Bazan NG and Allan G Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. 1996 Adv Neurol pmid:8790822
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Armant DR Intracellular Ca2+ signaling and preimplantation development. 2015 Adv. Exp. Med. Biol. pmid:25956298
Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. 1993 Adv. Exp. Med. Biol. pmid:7911646
Kornecki E et al. Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. 1987 Adv. Exp. Med. Biol. pmid:2893525
Hanahan DJ The continuing biochemical challenge of PAF and closely related lipid mediators. 1996 Adv. Exp. Med. Biol. pmid:9131117
Snyder F et al. Biosynthesis of platelet-activating factor and enzyme inhibitors. 1996 Adv. Exp. Med. Biol. pmid:9131118
Satoh K et al. Production of platelet-activating factor by brain microvascular endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131120
Francescangeli E et al. PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. 1996 Adv. Exp. Med. Biol. pmid:9131121
Yamada M et al. Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. 1996 Adv. Exp. Med. Biol. pmid:9131122
van den Bosch H et al. The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. 1996 Adv. Exp. Med. Biol. pmid:9131123
Dohi T et al. Platelet-activating factor synthesis and its role in salivary glands. 1996 Adv. Exp. Med. Biol. pmid:9131124
Nakayama R et al. Physiological action of PAF in yeast Saccharomyces cerevisiae. 1996 Adv. Exp. Med. Biol. pmid:9131125
Demopoulos CA and Antonopoulou S A discovery trip to compounds with PAF-like activity. 1996 Adv. Exp. Med. Biol. pmid:9131127
Rementzis J et al. Biologically active lipids from S. scombrus. 1996 Adv. Exp. Med. Biol. pmid:9131128
Korth RM Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131162
Zimmerman GA et al. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. 1996 Adv. Exp. Med. Biol. pmid:9131163
Yang HC et al. Characterization of plasmalogen-selective phospholipase A2 from bovine brain. 1996 Adv. Exp. Med. Biol. pmid:9131165
Ferby I et al. PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. 1996 Adv. Exp. Med. Biol. pmid:9131167
Thierse HJ et al. Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. 1996 Adv. Exp. Med. Biol. pmid:9131171
Schlondorff D Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. 1989 Adv. Exp. Med. Biol. pmid:2696352
Curtis LD Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. 1996 Adv. Exp. Med. Biol. pmid:9131174
Remuzzi G Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. 1989 Adv. Exp. Med. Biol. pmid:2696353
McKay C et al. The use of lexipafant in the treatment of acute pancreatitis. 1996 Adv. Exp. Med. Biol. pmid:9131175
Tamura G et al. Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. 1996 Adv. Exp. Med. Biol. pmid:9131176
Albert DH et al. Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. 1996 Adv. Exp. Med. Biol. pmid:9131177
Bussolino F et al. Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. 1991 Adv. Exp. Med. Biol. pmid:1767755
Tuffin DP et al. Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. 1985 Adv. Exp. Med. Biol. pmid:3834789
MacIntyre DE et al. Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. 1985 Adv. Exp. Med. Biol. pmid:3010662
Hallam TJ et al. Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. 1985 Adv. Exp. Med. Biol. pmid:3010663
Gerrard JM et al. Platelet protein phosphorylation. 1985 Adv. Exp. Med. Biol. pmid:3010667
Haslam RJ et al. Receptor-effector coupling in platelets: roles of guanine nucleotides. 1985 Adv. Exp. Med. Biol. pmid:3010668
Braquet P and Bourgain RH Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. 1987 Adv. Exp. Med. Biol. pmid:3314403
Winkler JD et al. Inhibitors of arachidonate metabolism and effects on PAF production. 1996 Adv. Exp. Med. Biol. pmid:9131119
Elizarova EP Effects of taurine on calcium in platelets and their aggregation. 1996 Adv. Exp. Med. Biol. pmid:8915398
Vadas P and Pruzanski W Phospholipase A2 activation is the pivotal step in the effector pathway of inflammation. 1990 Adv. Exp. Med. Biol. pmid:2239447