Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yan W et al. | BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. | 2015 | Int J Clin Exp Pathol | pmid:25973059 |
Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
Puebla-Osorio N et al. | Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. | 2015 | Cell Death Dis | pmid:25950475 |
Laidlaw TM and Boyce JA | Platelets in patients with aspirin-exacerbated respiratory disease. | 2015 | J. Allergy Clin. Immunol. | pmid:26051947 |
Kooijman S et al. | Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. | 2015 | J. Thromb. Haemost. | pmid:25345495 |
Jasamai M et al. | Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. | 2015 | Nat. Prod. Res. | pmid:25332053 |
Huang JF et al. | Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. | 2015 | BMC Ophthalmol | pmid:25956877 |
Sala-Cunill A and Cardona V | Biomarkers of anaphylaxis, beyond tryptase. | 2015 | Curr Opin Allergy Clin Immunol | pmid:26110683 |
Gao L et al. | Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. | 2015 | J. Clin. Invest. | pmid:26098214 |
Gill P et al. | Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. | 2015 | J. Allergy Clin. Immunol. | pmid:26051949 |
de Oliveira MC et al. | Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. | 2015 | J. Nutr. Biochem. | pmid:26013469 |
Jiao D et al. | Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. | 2014 May-Jun | Cell. Immunol. | pmid:24751884 |
Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
Flasiński M et al. | Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. | 2014 | J R Soc Interface | pmid:24694892 |
Sato A et al. | C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. | 2014 | Eur. J. Pharmacol. | pmid:25455842 |
Zebrowska A et al. | Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. | 2014 | Mediators Inflamm. | pmid:25400334 |
Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
Nitoda E et al. | Correlation of platelet activating factor and age-related macular degeneration. | 2014 | Expert Opin. Ther. Targets | pmid:25077601 |
Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
Xanthopoulou MN et al. | Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. | 2014 | Food Chem | pmid:25038648 |
Concha C et al. | Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. | 2014 | J. Vet. Sci. | pmid:25013355 |
Mazereeuw G et al. | Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study. | 2014 | J Neuroinflammation | pmid:24996486 |
Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
Triggiani M et al. | Anaphylaxis and cardiovascular diseases: a dangerous liaison. | 2014 | Curr Opin Allergy Clin Immunol | pmid:24915548 |
Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
Papakonstantinou VD et al. | In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients. | 2014 | Lipids Health Dis | pmid:24884881 |
Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
Yu Y et al. | Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. | 2014 | J Ovarian Res | pmid:24721622 |
Forkel S et al. | Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. | 2014 | J. Invest. Dermatol. | pmid:24714204 |
Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
Kaplanis M et al. | Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. | 2014 | J. Inorg. Biochem. | pmid:24632342 |
Mallet de Lima CD et al. | Central role of PAFR signalling in ExoU-induced NF-κB activation. | 2014 | Cell. Microbiol. | pmid:24612488 |
Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
Sugatani J et al. | Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. | 2014 | FASEB J. | pmid:24100020 |
Fang W et al. | Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. | 2014 | J. Neurochem. | pmid:24164378 |
Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
Rivera J et al. | Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. | 2014 | J. Biol. Chem. | pmid:24478317 |
Kim KJ et al. | Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. | 2014 | Immunology | pmid:24628121 |
Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
Yang Y et al. | Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. | 2014 | Eur. J. Immunol. | pmid:24777913 |
Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |