Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Albert DH et al. | The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435164 |
| Li CL and Wong YY | The bioavailability of ginkgolides in Ginkgo biloba extracts. | 1997 | Planta Med. | pmid:9434615 |
| Dupuis F et al. | Production, metabolism and effect of platelet-activating factor on the growth of the human K562 erythroid cell line. | 1997 | Biochim. Biophys. Acta | pmid:9434130 |
| Bennett SA and Birnboim HC | Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor. | 1997 | Mol. Carcinog. | pmid:9433481 |
| Stack WA and Hawkey CJ | Specific mediator-directed therapy for gastrointestinal diseases. | 1997 | Eur J Gastroenterol Hepatol | pmid:9431894 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Igarashi Y | [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. | 1997 | Seikagaku | pmid:9431007 |
| Hichami A et al. | Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells. | 1997 | Eur. J. Biochem. | pmid:9428670 |
| Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
| Shamsuddin M et al. | Regulation of leukotriene and platelet-activating factor synthesis in human alveolar macrophages. | 1997 | J. Lab. Clin. Med. | pmid:9422335 |
| Mugnai S et al. | Influence of interleukin 1alpha on superoxide anion, platelet activating factor release and phospholipase A2 activity of naive and sensitized guinea-pig alveolar macrophages. | 1997 | Br. J. Pharmacol. | pmid:9421281 |
| Prescott SM | Inflammatory actions of platelet-activating factor: control by PAF acetylhydrolase. | 1997 Sep-Oct | J Investig Allergol Clin Immunol | pmid:9416565 |
| Maeda T et al. | Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. | 1997 | Acta Neurochir. Suppl. | pmid:9416292 |
| Manabe H et al. | KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414145 |
| Sozzani S et al. | Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor. | 1997 | FEBS Lett. | pmid:9414103 |
| Zimmerman GA et al. | Adhesion and signaling in vascular cell-cell interactions. | 1997 | J. Clin. Invest. | pmid:9413392 |
| Bix GJ and Clark GD | Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro. | 1998 | J. Neurosci. | pmid:9412509 |
| Kertscher HP | [PAF-antagonists with lipid structure. 6. Alkylpropandiol lipids with acyl- and ether- structures at the C-3 position and heterocyclic head groups; synthesis, characterization and structure-activity relationship]. | 1997 | Pharmazie | pmid:9411454 |
| Camici M et al. | [Platelet activating factor (PAF) and kidney failure progression]. | 1997 | Minerva Med. | pmid:9411309 |
| Zinchenko VP et al. | [Effect of structural analogs of platelet activating factor on the intracellular signal transduction in murine peritoneal neutrophils and macrophages of P388D1 line]. | 1997 Sep-Oct | Biofizika | pmid:9410037 |
| Adachi T et al. | PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells. | 1997 | Neurosci. Lett. | pmid:9406887 |
| Tabuchi S et al. | Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. | 1997 | Neurosci. Lett. | pmid:9406868 |
| Coffer PJ et al. | Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. | 1998 | Biochem. J. | pmid:9405284 |
| Soubeyrand S et al. | Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase. | 1998 | Biochem. J. | pmid:9405273 |
| Uozumi N et al. | Role of cytosolic phospholipase A2 in allergic response and parturition. | 1997 | Nature | pmid:9403692 |
| Lo CJ et al. | Endotoxin-induced macrophage gene expression depends on platelet-activating factor. | 1997 | Arch Surg | pmid:9403541 |
| Bix GJ and Clark GD | Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. | 1997 | J. Neurosci. Methods | pmid:9402559 |
| Erickson KL et al. | Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. | 1997 | J. Leukoc. Biol. | pmid:9400826 |
| el-Shazly AE et al. | Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. | 1997 Aug-Dec | Immunol. Invest. | pmid:9399104 |
| Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
| Negro Alvarez JM et al. | Platelet-activating factor antagonists. | 1997 Sep-Oct | Allergol Immunopathol (Madr) | pmid:9395010 |
| Im SY et al. | Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. | 1997 | Eur. J. Immunol. | pmid:9394802 |
| Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
| Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
| Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
| Cheng D and Chen W | [The role of platelet activating factor in chronic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389061 |
| Cheng D et al. | [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389027 |
| Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
| Yu P et al. | [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. | 1996 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:9387456 |
| Sapir T et al. | Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. | 1997 | EMBO J. | pmid:9384577 |
| Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
| Kozai T et al. | Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. | 1997 | Coron. Artery Dis. | pmid:9383603 |
| Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
| Mantovani A | The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. | 1997 | Drugs | pmid:9378074 |
| Okada S et al. | Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9376127 |
| Mori M et al. | Localization of platelet-activating factor receptor messenger RNA in the rat eye. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375587 |
| Bazan HE et al. | Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375567 |
| Miyahara T et al. | Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. | 1997 | J. Appl. Physiol. | pmid:9375313 |
| Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
| Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |
| Nagase T et al. | Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9372685 |
| Snyder F | CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. | 1997 | Biochim. Biophys. Acta | pmid:9370322 |
| Saeed SA et al. | Anti-thrombotic and anti-inflammatory activities of protopine. | 1997 | Pharmacol. Res. | pmid:9368908 |
| Manna SK et al. | Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. | 1997 | J. Immunol. | pmid:9366432 |
| Kishimoto S et al. | Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363928 |
| Hershkowitz M and Adunsky A | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. | 1996 Nov-Dec | Neurobiol. Aging | pmid:9363797 |
| Radonjic-Lazovic G and Roudebush WE | The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. | 1995 | Early Pregnancy | pmid:9363251 |
| May JA et al. | Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. | 1997 | Thromb. Res. | pmid:9361371 |
| Wang H et al. | Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. | 1997 | Pediatr. Res. | pmid:9357930 |
| Silomon M et al. | Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. | 1997 | J. Surg. Res. | pmid:9356229 |
| Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
| Nagaoka H et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). | 1997 | Chem. Pharm. Bull. | pmid:9353894 |
| Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |
| Denham W et al. | Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. | 1997 | Gastroenterology | pmid:9352880 |
| Bzeizi KI et al. | Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. | 1997 | Liver Transpl Surg | pmid:9346727 |
| Aspey BS et al. | Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. | 1997 | Metab Brain Dis | pmid:9346472 |
| Million M et al. | Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. | 1997 | Eur. J. Pharmacol. | pmid:9346330 |
| Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
| Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
| Rezaul K et al. | Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345263 |
| Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
| Francescangeli E et al. | Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. | 1997 | Neurochem. Res. | pmid:9342735 |
| Hirashima Y et al. | Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. | 1997 | Neurochem. Res. | pmid:9342729 |
| Ohashi Y et al. | Platelet activating factor compromises airway epithelial defense functions. | 1997 | J. Allergy Clin. Immunol. | pmid:9338547 |
| Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
| Getting SJ et al. | Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336316 |
| Knight D et al. | Adenosine A3 receptor stimulation inhibits migration of human eosinophils. | 1997 | J. Leukoc. Biol. | pmid:9335316 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Weber C and Springer TA | Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. | 1997 | J. Clin. Invest. | pmid:9329974 |
| DeLano FA et al. | Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade. | 1997 | Microcirculation | pmid:9329011 |
| Murray J et al. | Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. | 1997 | Blood | pmid:9326245 |
| Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
| Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
| Wan S et al. | Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. | 1997 | Chest | pmid:9315800 |
| Cepinskas G et al. | Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement. | 1997 | Circ. Res. | pmid:9314844 |
| Teixeira MM et al. | Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. | 1997 | J. Clin. Invest. | pmid:9312163 |
| Cortijo J et al. | Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro. | 1997 | Eur. J. Pharmacol. | pmid:9311663 |
| Tailor A et al. | Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. | 1997 | J. Leukoc. Biol. | pmid:9307068 |
| Oh-ishi S | [Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9306414 |
| Ablett JM et al. | Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. | 1997 | Equine Vet. J. | pmid:9306066 |
| Balsa D et al. | Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. | 1997 | J Lipid Mediat Cell Signal | pmid:9302653 |
| Bialasiewicz P et al. | Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients. | 1997 | J Lipid Mediat Cell Signal | pmid:9302652 |
| Herbert JM et al. | Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. | 1997 | J Lipid Mediat Cell Signal | pmid:9302650 |
| Kimura M et al. | Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9301630 |
| Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |