Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Agrawal V et al. | Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | 2014 | Biol. Reprod. | pmid:25253732 |
| Wang M et al. | Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine. | 2014 | Life Sci. | pmid:25252221 |
| Liu X et al. | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. | 2014 | Thromb. Res. | pmid:25223809 |
| Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
| Wu KZ et al. | Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. | 2014 | Interdiscip Sci | pmid:25172450 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
| Reyes-Quiroz ME et al. | Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. | 2014 | FEBS J. | pmid:24289152 |
| Semini G et al. | Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. | 2014 | Biochem. Pharmacol. | pmid:24291779 |
| Morimoto R et al. | Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. | 2014 | J. Biol. Chem. | pmid:24742674 |
| Frazer CA | Heparin-induced thrombocytopenia. | 2013 Nov-Dec | Medsurg Nurs | pmid:24600938 |
| Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
| Herndon B et al. | Urease and Helicobacter spp. antigens in pulmonary granuloma. | 2013 | J. Comp. Pathol. | pmid:22901429 |
| Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
| Sato A et al. | An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. | 2013 | Eur. J. Pharmacol. | pmid:23792041 |
| Ayaz G et al. | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. | 2013 | Gene | pmid:23816407 |
| Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
| Wang C et al. | Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. | 2013 | Lipids Health Dis | pmid:23805935 |
| Nettis E et al. | Rupatadine for the treatment of urticaria. | 2013 | Expert Opin Pharmacother | pmid:23806068 |
| Sato A and Ebina K | [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. | 2013 | Seikagaku | pmid:23819394 |
| Compalati E and Canonica GW | Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. | 2013 | Curr Med Res Opin | pmid:23826741 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Motoyama N et al. | Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. | 2013 | Eur J Pain | pmid:23355413 |
| Tsoupras AB et al. | Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. | 2013 | J. Inorg. Biochem. | pmid:23318288 |
| Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
| Vanstreels L and Merk HF | [Value of in-vitro diagnostic tools after anaphylaxis]. | 2013 | Hautarzt | pmid:23385619 |
| Sato A and Ebina K | Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. | 2013 | Inflamm. Res. | pmid:23370722 |
| Singh P et al. | Platelet-activating factor (PAF)-antagonists of natural origin. | 2013 | Fitoterapia | pmid:23160091 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
| Murakami M and Lambeau G | Emerging roles of secreted phospholipase A(2) enzymes: an update. | 2013 | Biochimie | pmid:23022039 |
| Vadas P et al. | Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. | 2013 | J. Allergy Clin. Immunol. | pmid:23040367 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
| Maziero AM et al. | Inhibition of human platelet aggregation by eosinophils. | 2013 | Life Sci. | pmid:23871985 |
| Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
| Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
| Sahu RP et al. | Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. | 2013 | J. Immunol. | pmid:23355733 |
| Berman B and Cockerell CJ | Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. | 2013 | J. Am. Acad. Dermatol. | pmid:23228301 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Renteria LS et al. | RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. | 2013 | Cell Prolif. | pmid:24033386 |
| Verouti SN et al. | Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. | 2013 | Int J Artif Organs | pmid:23335378 |
| Zhao C et al. | Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. | 2013 | PLoS ONE | pmid:24367540 |
| Barbier M et al. | Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. | 2013 | MBio | pmid:23653444 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |