Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
| Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
| Hines KL and Fisher RA | Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis. | 1992 | Am. J. Physiol. | pmid:1375439 |
| Kubes P et al. | Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine. | 1995 | Am. J. Physiol. | pmid:7631799 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Zimmerman BJ et al. | Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. | 1994 | Am. J. Physiol. | pmid:8160832 |
| Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
| Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
| Del Maschio A et al. | Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. | 1990 | Am. J. Physiol. | pmid:2156456 |
| Asako H et al. | Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery. | 1992 | Am. J. Physiol. | pmid:1362329 |
| DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |
| McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
| Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
| Munoz NM et al. | Effects of PAF on isolated rat airways perfused with blood-free solution. | 1991 | Am. J. Physiol. | pmid:2018147 |
| Olson NC et al. | Role of platelet-activating factor and eicosanoids during endotoxin-induced lung injury in pigs. | 1990 | Am. J. Physiol. | pmid:2163217 |
| Yamazaki M et al. | Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. | 1991 | Am. J. Physiol. | pmid:1653524 |
| Gaboury JP et al. | Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo. | 1994 | Am. J. Physiol. | pmid:7908174 |
| Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
| Kubes P et al. | Platelet-activating factor-induced mucosal dysfunction: role of oxidants and granulocytes. | 1991 | Am. J. Physiol. | pmid:1647676 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
| Sirén AL and Feuerstein G | Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats. | 1989 | Am. J. Physiol. | pmid:2546449 |
| Wallace JL et al. | Platelet-activating factor mediates gastric damage induced by hemorrhagic shock. | 1990 | Am. J. Physiol. | pmid:2372058 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Kubes P et al. | Leukocyte-induced vascular protein leakage in cat mesentery. | 1991 | Am. J. Physiol. | pmid:1684268 |
| Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
| Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
| Halonen M et al. | Anatomic basis for species differences in peripheral lung strip contraction to PAF. | 1990 | Am. J. Physiol. | pmid:2382734 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Neuwirth R et al. | Extra- and intracellular metabolism of platelet-activating factor by cultured mesangial cells. | 1989 | Am. J. Physiol. | pmid:2705543 |
| Kinnula VL et al. | Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro. | 1992 | Am. J. Physiol. | pmid:1616055 |
| Gao Y et al. | PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. | 1995 | Am. J. Physiol. | pmid:7653635 |
| Kim D and Durán WN | Platelet-activating factor stimulates protein tyrosine kinase in hamster cheek pouch microcirculation. | 1995 | Am. J. Physiol. | pmid:7530921 |
| Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
| Wood JG et al. | Gastric microvascular actions of platelet-activating factor: role of leukocytes. | 1992 | Am. J. Physiol. | pmid:1550241 |
| Zheng ZG et al. | Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. | 1993 | Am. J. Physiol. | pmid:8430791 |
| Conyers G et al. | A factor in serum lowers resistance and opens tight junctions of MDCK cells. | 1990 | Am. J. Physiol. | pmid:2221039 |
| Badr KF et al. | Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. | 1989 | Am. J. Physiol. | pmid:2912165 |
| Kvietys PR et al. | Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. | 1990 | Am. J. Physiol. | pmid:2221068 |
| Harris NR et al. | Capillary filtration during acute inflammation: role of adherent neutrophils. | 1993 | Am. J. Physiol. | pmid:7902014 |
| Kalra VK et al. | Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | 1996 | Am. J. Physiol. | pmid:8945922 |
| Kelly KJ et al. | An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. | 1996 | Am. J. Physiol. | pmid:8946001 |
| Gallin EK | Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. | 1989 | Am. J. Physiol. | pmid:2750892 |
| Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
| Huang YC et al. | Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung. | 1994 | Am. J. Physiol. | pmid:7513130 |
| Zhou W et al. | Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. | 1992 | Am. J. Physiol. | pmid:1443133 |
| Kanwar S et al. | Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. | 1994 | Am. J. Physiol. | pmid:8141295 |
| Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Bienvenu K et al. | Modulation of leukocyte migration in mesenteric interstitium. | 1994 | Am. J. Physiol. | pmid:7943404 |
| Church DJ et al. | Calcium influx in platelet activating factor-induced atrial natriuretic peptide release in rat cardiomyocytes. | 1994 | Am. J. Physiol. | pmid:8166260 |
| Perico N et al. | Platelet-activating factor alters glomerular barrier size selectivity for macromolecules in rats. | 1991 | Am. J. Physiol. | pmid:1713421 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Kornecki E and Ehrlich YH | Diminished responsiveness of human platelets to platelet-activating factor during pregnancy. | 1990 | Am. J. Physiol. | pmid:2396687 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
| Rabe KF et al. | Contraction of human bronchial smooth muscle caused by activated human eosinophils. | 1994 | Am. J. Physiol. | pmid:7943259 |
| Bradley LM et al. | Circulatory effects of PAF-acether in newborn piglets. | 1989 | Am. J. Physiol. | pmid:2912183 |
| Koyama S et al. | Type II pneumocytes release chemoattractant activity for monocytes constitutively. | 1997 | Am. J. Physiol. | pmid:9176245 |
| Chang SW et al. | Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor. | 1989 | Am. J. Physiol. | pmid:2801951 |
| Mózes T et al. | Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. | 1989 | Am. J. Physiol. | pmid:2802004 |
| Kobayashi I et al. | Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. | 1994 | Am. J. Physiol. | pmid:8160825 |
| Hines KL et al. | PAF increases hepatic vascular resistance and glycogenolysis in vivo. | 1991 | Am. J. Physiol. | pmid:1848410 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
| Chang SW et al. | Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. | 1990 | Am. J. Physiol. | pmid:2301603 |
| Pique JM et al. | Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. | 1990 | Am. J. Physiol. | pmid:2316650 |
| Snyder F | Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. | 1990 | Am. J. Physiol. | pmid:2240190 |
| Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
| Kubes P et al. | Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. | 1990 | Am. J. Physiol. | pmid:2240225 |
| Sobhani I et al. | Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands. | 1995 | Am. J. Physiol. | pmid:7611410 |
| Marchetti J et al. | The parietal sheet of Bowman's capsule of rat renal glomerulus: a target of endothelin and PAF. | 1995 | Am. J. Physiol. | pmid:7611446 |
| Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Wallace JL | Lipid mediators of inflammation in gastric ulcer. | 1990 | Am. J. Physiol. | pmid:2405704 |
| Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
| Martins MA et al. | Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs. | 1991 | Am. J. Physiol. | pmid:1722649 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Johnson A et al. | Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1991 | Am. J. Physiol. | pmid:1656789 |
| Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
| Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
| Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |