Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schaefer MB et al. | Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | 2008 | Eur. Respir. J. | pmid:18653653 |
| Samanta U and Bahnson BJ | Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. | 2008 | J. Biol. Chem. | pmid:18784071 |
| Beuk RJ et al. | Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. | 2008 | Br J Surg | pmid:18720462 |
| Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
| Kuliszkiewicz-Janus M et al. | Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. | 2008 | Cell. Mol. Biol. Lett. | pmid:17952375 |
| Leong HS et al. | Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. | 2008 | J. Leukoc. Biol. | pmid:17974709 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| Gountopoulou A et al. | TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. | 2008 | Cytokine | pmid:18180165 |
| Kwasniewski FH et al. | Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | 2008 | Int. Immunopharmacol. | pmid:18182253 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Zhang Q et al. | UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. | 2008 | J. Invest. Dermatol. | pmid:18200048 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Harayama T et al. | Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. | 2008 | J. Biol. Chem. | pmid:18285344 |
| Mizutani T et al. | Genuine functions of P-glycoprotein (ABCB1). | 2008 | Curr. Drug Metab. | pmid:18288958 |
| Fukunaga A et al. | Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. | 2008 | J. Immunol. | pmid:18292528 |
| van Zoelen MA et al. | Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. | 2008 | J. Immunol. | pmid:18292561 |
| Knapp S et al. | Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. | 2008 | J. Immunol. | pmid:18292574 |
| Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
| Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
| Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
| McLaughlin NJ et al. | Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. | 2008 | J. Immunol. | pmid:18523285 |
| Felfernig M et al. | Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. | 2008 | J R Nav Med Serv | pmid:18524134 |
| Tsoupras AB et al. | Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? | 2008 | AIDS Res. Hum. Retroviruses | pmid:18620493 |
| Corl CM et al. | Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. | 2008 | J. Dairy Sci. | pmid:18650283 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
| Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
| Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
| Xu W et al. | Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. | 2007 | Chin. Med. J. | pmid:18028783 |
| Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
| Doublier S et al. | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. | 2007 | Clin. Cancer Res. | pmid:17908960 |
| Shimada T et al. | Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. | 2007 | J. Endocrinol. | pmid:17911394 |
| Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
| Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
| Keam SJ and Plosker GL | Rupatadine: a review of its use in the management of allergic disorders. | 2007 | Drugs | pmid:17335300 |
| Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
| Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
| Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
| Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
| Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
| Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
| Witzenrath M et al. | Role of platelet-activating factor in pneumolysin-induced acute lung injury. | 2007 | Crit. Care Med. | pmid:17522574 |
| Keles GC et al. | Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. | 2007 | Clin Oral Investig | pmid:17522901 |
| Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
| Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
| Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
| Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
| Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
| Tosaki T et al. | Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. | 2007 | Biol. Pharm. Bull. | pmid:17268064 |
| Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
| Souza LJ et al. | Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. | 2007 | Pancreatology | pmid:17449968 |
| Shin CR et al. | Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. | 2007 | J. Periodont. Res. | pmid:17451539 |
| Truffinet V et al. | No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. | 2007 | Leuk. Res. | pmid:17350684 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Paterson WG et al. | Role of platelet-activating factor in acid-induced esophageal mucosal injury. | 2007 | Dig. Dis. Sci. | pmid:17415649 |
| Tsimikas S et al. | New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17626905 |
| Li Y et al. | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. | 2007 | Biol. Reprod. | pmid:17634444 |
| Nagi-Miura N et al. | Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. | 2007 | Biol. Pharm. Bull. | pmid:17603181 |
| Kooyman FN et al. | Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. | 2007 | Infect. Immun. | pmid:17606606 |
| Dupré DJ et al. | Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. | 2007 | Cell. Signal. | pmid:17609120 |
| Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
| Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
| Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
| Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
| Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
| Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
| Dunkel B et al. | Platelet activation in ponies with airway inflammation. | 2007 | Equine Vet. J. | pmid:18065316 |
| Wang J et al. | Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. | 2007 | Int. J. Cardiol. | pmid:16887214 |
| Lu SM et al. | The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. | 2007 | J Neuroimmune Pharmacol | pmid:18040844 |
| Tsantila N et al. | Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. | 2007 | Mediators Inflamm. | pmid:18253466 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
| Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
| Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
| Tsoupras AB et al. | Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | 2007 | Mediators Inflamm. | pmid:17710109 |
| Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
| Takahashi T et al. | Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. | 2007 | Microvasc. Res. | pmid:17027041 |
| Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
| Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |
| Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
| Saluk-Juszczak J et al. | The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. | 2007 | Curr. Microbiol. | pmid:17160361 |
| Huang YH et al. | Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. | 2007 | J. Cell. Biochem. | pmid:17131380 |
| Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
| Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
| Ko HM et al. | Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. | 2007 | Int. J. Cancer | pmid:17187368 |
| Bate C et al. | Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 | J Neuroinflammation | pmid:17233902 |
| Caini P et al. | Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. | 2007 | J. Viral Hepat. | pmid:17212640 |
| Callender HL et al. | Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. | 2007 | Anal. Chem. | pmid:17194150 |
| Heusler P and Boehmer G | Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. | 2007 | Brain Res. | pmid:17196945 |
| Fragopoulou E et al. | Biological activity of acetylated phenolic compounds. | 2007 | J. Agric. Food Chem. | pmid:17199317 |
| Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
| Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Eckert RE and Jones SL | Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. | 2007 | J. Leukoc. Biol. | pmid:17684042 |