Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Taylor ML et al. | Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects. | 1996 | Clin. Exp. Allergy | pmid:8835129 |
| Barkai U and Kraicer PF | Intrauterine signaling and embryonic implantation. | 1996 Mar-Apr | Biol. Signals | pmid:8836494 |
| Louis RE and Radermecker MF | Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine. | 1996 | Eur. Respir. J. | pmid:8836652 |
| Kurata M et al. | A comparative study of whole-blood platelet aggregation in laboratory animals: its species differences and comparison with turbidimetric method. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:8838690 |
| Imagawa M et al. | Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. | 1996 | Urol. Int. | pmid:8840484 |
| Isogai E et al. | [Platelet activating factor (PAF) and Lyme disease]. | 1996 | Nippon Saikingaku Zasshi | pmid:8840817 |
| Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
| Paulino N et al. | Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red. | 1996 | Gen. Pharmacol. | pmid:8842681 |
| Kemény L et al. | Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice. | 1996 | Arch. Dermatol. Res. | pmid:8844132 |
| Libert C et al. | Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality. | 1995-1996 | J. Inflamm. | pmid:8844494 |
| Yokota K et al. | Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8847836 |
| Hahn M et al. | Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation. | 1995 | Cardiovasc Drugs Ther | pmid:8850387 |
| Renesto P et al. | Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils. | 1996 | Br. J. Pharmacol. | pmid:8851508 |
| Hoffman BF et al. | Arrhythmias caused by platelet activating factor. | 1996 | J. Cardiovasc. Electrophysiol. | pmid:8853022 |
| Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
| Ebara T et al. | Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock. | 1996 | Jpn. J. Pharmacol. | pmid:8854207 |
| Chen CC et al. | Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8856479 |
| Albert DH et al. | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. | 1996 | Shock | pmid:8856845 |
| Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
| Abu-Zidan FM et al. | Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs. | 1996 | J Trauma | pmid:8858021 |
| Lopes-Martins R et al. | Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure. | 1996 | Eur. J. Pharmacol. | pmid:8858301 |
| Shi LC et al. | Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. | 1996 | J. Neurochem. | pmid:8858930 |
| Jouët P and Sarna SK | Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8858995 |
| Saito H et al. | Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8859220 |
| Wang X et al. | Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. | 1996 Sep-Oct | J. Vasc. Res. | pmid:8862147 |
| Denizot Y et al. | PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells. | 1996 | Exp. Hematol. | pmid:8862444 |
| Kingsnorth AN | Platelet-activating factor. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8865468 |
| Medina JH and Izquierdo I | Retrograde messengers, long-term potentiation and memory. | 1995 | Brain Res. Brain Res. Rev. | pmid:8866674 |
| Kamata K et al. | Characteristics of vasodilatation induced by acetylcholine and platelet-activating factor in the rat mesenteric arterial bed. | 1996 | Eur. J. Pharmacol. | pmid:8867099 |
| Ackerman Z et al. | Gastric and colonic inflammatory and vasoactive mediators in experimental portal hypertension. | 1996 | Liver | pmid:8868072 |
| Guastoni C et al. | Mechanisms and kinetics of the synthesis and release of platelet-activating factor (PAF) by polyacrylonitrile membranes. | 1996 | Clin. Nephrol. | pmid:8869791 |
| Elferink JG and de Koster BM | Modulation of human neutrophil chemotaxis by the endothelin-B receptor agonist sarafotoxin S6c. | 1996 | Chem. Biol. Interact. | pmid:8870686 |
| Huang YH et al. | Induction of IL-4 by platelet-activating factor. | 1996 | Clin. Exp. Immunol. | pmid:8870712 |
| Weller PF et al. | Role of the eosinophil in allergic reactions. | 1996 | Eur Respir J Suppl | pmid:8871054 |
| Kecskeméti V and Balogh I | Cardiac ultrastructural effects of the platelet-activating factor and its antagonist BN 52021. | 1995 | Exp. Toxicol. Pathol. | pmid:8871085 |
| Baluk P et al. | NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules. | 1996 Jul-Aug | Exp. Lung Res. | pmid:8872085 |
| Poch B et al. | Release of histamine in whole blood by oxygen radicals: division between specific and unspecific processes. | 1996 | Inflamm. Res. | pmid:8872518 |
| Balsa D et al. | Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method. | 1996 | J Pharmacol Toxicol Methods | pmid:8872920 |
| Tenscher K et al. | Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. | 1996 | Blood | pmid:8874220 |
| Takafuji S et al. | Effects of interleukin (IL)-3 and IL-5 on human eosinophil degranulation induced by complement components C3a and C5a. | 1996 | Allergy | pmid:8874660 |
| Verhoef J et al. | Issues in the adjunct therapy of severe sepsis. | 1996 | J. Antimicrob. Chemother. | pmid:8877531 |
| Zimmerman GA et al. | Adhesion and signaling in vascular cell--cell interactions. | 1996 | J. Clin. Invest. | pmid:8878418 |
| Fukao M et al. | Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8878540 |
| Fairbairn SM et al. | Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. | 1996 | Res. Vet. Sci. | pmid:8880978 |
| Perretti M et al. | Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. | 1996 | Br. J. Pharmacol. | pmid:8882609 |
| Siegel A and Baker RR | Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia. | 1996 | Biochem. Cell Biol. | pmid:8883840 |
| Ferreira HH et al. | Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis. | 1996 | Eur. J. Pharmacol. | pmid:8884218 |
| Enzan K et al. | Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. | 1996 | Shock | pmid:8885083 |
| Niu XF et al. | A balance between nitric oxide and oxidants regulates mast cell-dependent neutrophil-endothelial cell interactions. | 1996 | Circ. Res. | pmid:8888691 |
| Nishida K and Markey SP | Nicardipine and MK-801 attenuate platelet-activating factor increases following cerebral ischemia-reperfusion in gerbils. | 1996 | Brain Res. | pmid:8891303 |
| Alves AC et al. | Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. | 1996 | Eur. J. Pharmacol. | pmid:8891583 |
| Krüll M et al. | Escherichia coli hemolysin and Staphylococcus aureas alpha-toxin potently induce neutrophil adhesion to cultured human endothelial cells. | 1996 | J. Immunol. | pmid:8892649 |
| Mancuso F et al. | Inhibition of zymosan-induced air-pouch inflammation by rat seminal vesicle protein and by its spermidine derivative. | 1996 | Eur. J. Pharmacol. | pmid:8894615 |
| Ishizuka T et al. | Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stimulated vascular endothelial cells. | 1996 | Eur. J. Pharmacol. | pmid:8894620 |
| Winlove CP et al. | Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties. | 1996 | Diabetologia | pmid:8896999 |
| Lithner F | Diabetes mellitus and Alzheimer's disease. | 1996 | Diabetologia | pmid:8897018 |
| Cominacini L et al. | Increased levels of plasma ELAM-1, ICAM-1 and VCAM-1 in NIDDM: possible role of oxidized LDL. | 1996 | Diabetologia | pmid:8897020 |
| Catalán RE et al. | Endothelin stimulates phosphoinositide hydrolysis and PAF synthesis in brain microvessels. | 1996 | J. Cereb. Blood Flow Metab. | pmid:8898708 |
| Kishi K et al. | Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway. | 1996 | J. Biol. Chem. | pmid:8900127 |
| Cortijo J et al. | Antiasthma activity of the novel antihistamine E-4716 in guinea pigs in vivo. | 1996 | Methods Find Exp Clin Pharmacol | pmid:8900220 |
| Fujimura M et al. | Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs. | 1996 | Eur. Respir. J. | pmid:8902468 |
| Koyama M et al. | Surface coverage of vascular grafts with cultured human endothelial cells from subcutaneous fat tissue obtained with a biopsy needle. | 1996 | Thromb. Haemost. | pmid:8903004 |
| Greenberg SS et al. | Ethanol suppresses endotoxin but not platelet activating factor-induced hypotension and nitric oxide. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8904980 |
| Kishimoto S et al. | Enhanced expression of platelet-activating factor receptor on human eosinophils by interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. | 1996 | Int. Arch. Allergy Immunol. | pmid:8906117 |
| Neville LF et al. | Application of differential display to isolate novel genes in interleukin-2-induced adult respiratory distress syndrome. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906233 |
| Francescangeli E et al. | Relative contribution of the de novo and remodelling pathways to the synthesis of platelet-activating factor in brain areas and during ischemia. | 1996 | J Lipid Mediat Cell Signal | pmid:8906550 |
| Hattori M et al. | PAF and PAF acetylhydrolase in the nervous system. | 1996 | J Lipid Mediat Cell Signal | pmid:8906551 |
| Shimizu T et al. | Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release. | 1996 | J Lipid Mediat Cell Signal | pmid:8906552 |
| Feuerstein GZ | Platelet-activating factor: a case for its role in CNS function and brain injury. | 1996 | J Lipid Mediat Cell Signal | pmid:8906553 |
| Kornecki E et al. | Platelet activating factor (PAF) in memory formation: role as a retrograde messenger in long-term potentiation. | 1996 | J Lipid Mediat Cell Signal | pmid:8906554 |
| Bazan NG and Allan G | Platelet-activating factor in the modulation of excitatory amino acid neurotransmitter release and of gene expression. | 1996 | J Lipid Mediat Cell Signal | pmid:8906578 |
| Williams JH | Retrograde messengers and long-term potentiation: a progress report. | 1996 | J Lipid Mediat Cell Signal | pmid:8906579 |
| Kato K and Zorumski CF | Platelet-activating factor as a potential retrograde messenger. | 1996 | J Lipid Mediat Cell Signal | pmid:8906580 |
| Thivierge M et al. | Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation. | 1996 | J. Immunol. | pmid:8906849 |
| Kleuser B et al. | Measurement of phospholipase A2 and 1-alkylglycerophosphocholine acetyltransferase activities in stimulated alveolar macrophages by HPLC analysis of NBD-labeled ether lipids. | 1996 | Chem. Phys. Lipids | pmid:8907240 |
| Herbert JM et al. | Hypoxia primes endotoxin-induced tissue factor expression in human monocytes and endothelial cells by a PAF-dependent mechanism. | 1996 | J. Cell. Physiol. | pmid:8908196 |
| Richardson RM et al. | Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. | 1996 | J. Biol. Chem. | pmid:8910508 |
| MartÃnez-Cuesta MA et al. | Involvement of prostaglandins and 5-hydroxytryptamine in the contractile effect of platelet-activating factor in rat isolated gastric corpus. | 1996 | J. Pharm. Pharmacol. | pmid:8910861 |
| Condliffe AM et al. | Priming differentially regulates neutrophil adhesion molecule expression/function. | 1996 | Immunology | pmid:8911147 |
| Walsh GM et al. | Integrin alpha 4 beta 7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. | 1996 | Immunology | pmid:8911148 |
| Elizarova EP | Effects of taurine on calcium in platelets and their aggregation. | 1996 | Adv. Exp. Med. Biol. | pmid:8915398 |
| Kimura S et al. | Heterogeneity of drug susceptibility of mouse active anaphylactic shock. | 1996 Sep-Nov | Immunol. Invest. | pmid:8915680 |
| Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
| Liu CY and Kuo HP | The different effect of salbutamol and aminophylline on platelet activating factor-induced plasma exudation into guinea pig tracheal wall and lumen. | 1996 | Changgeng Yi Xue Za Zhi | pmid:8921637 |
| Wang KS and Monden M | Ex vivo evidence of platelet activating factor on ischemic liver injury. | 1996 | Changgeng Yi Xue Za Zhi | pmid:8921640 |
| da Silva MB et al. | Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. | 1996 | Zentralbl Veterinarmed A | pmid:8921726 |
| Kurosawa M et al. | CV6209 inhibits airway wall thickening and airway hyperresponsiveness to histamine induced by intravenous administration of platelet-activating factor in guinea pigs. | 1996 | J Lipid Mediat Cell Signal | pmid:8925195 |
| Nowak D et al. | Comparison of PAF- and fMLP-induced [Ca2+]i transients in human polymorphonuclear leukocytes. | 1996 | J Lipid Mediat Cell Signal | pmid:8925197 |
| Montrucchio G et al. | Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet activating factor and P-selectin. | 1996 | Circulation | pmid:8925584 |
| Walker BA | Effects of adenosine on guinea pig pulmonary eosinophils. | 1996 | Inflammation | pmid:8926045 |
| Staffolani N et al. | [The measurement of PAF (platelet activating factor) in human saliva: standardization of the method]. | 1996 | Minerva Stomatol | pmid:8926976 |
| Brus F et al. | Activation of circulating polymorphonuclear leukocytes in preterm infants with severe idiopathic respiratory distress syndrome. | 1996 | Pediatr. Res. | pmid:8929866 |
| Cardile V et al. | The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. | 1996 | Cytokine | pmid:8932980 |
| el-Shazly AE et al. | Inhibition of human eosinophil chemotaxis in vitro by the anti-allergic agent emedastine difumarate. | 1996 | Immunopharmacol Immunotoxicol | pmid:8933171 |
| Qu X et al. | Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. | 1996 | Prostaglandins | pmid:8935185 |
| Muraki T et al. | Effect of S-ethylisothiourea, a putative inhibitor of inducible nitric oxide synthase, on mouse skin vascular permeability. | 1996 | Jpn. J. Pharmacol. | pmid:8935721 |
| Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
| Uhlig S et al. | Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation in isolated rat lung. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8938670 |
| Tocher DR et al. | Production of eicosanoids derived from 20:4n-6 and 20:5n-3 in primary cultures of turbot (Scophthalmus maximus) brain astrocytes in response to platelet activating factor, substance P and interleukin-1 beta. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8939002 |
| Darbha S and Marchase RB | Regulation of intracellular calcium is closely linked to glucose metabolism in J774 macrophages. | 1996 | Cell Calcium | pmid:8939356 |