Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Machado GB et al. | Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. | 2011 | Respir. Res. | pmid:21819560 |
| Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Inoue T and Kannan MS | Platelet-activating factor-induced functional changes in the guinea pig trachea in vitro. | 1989 | Respir Physiol | pmid:2781159 |
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Pesce L et al. | Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs. | 1998 | Respir Physiol | pmid:9865589 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Steer ML | Relationship between pancreatitis and lung diseases. | 2001 | Respir Physiol | pmid:11535257 |
| Raj JU et al. | Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. | 1992 Apr-May | Respir Physiol | pmid:1626132 |
| Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Kroegel C et al. | Cytokines, platelet activating factor and eosinophils in asthma. | 1992 | Respir Med | pmid:1462017 |
| Barnes NC | New developments in the treatment of asthma and chronic obstructive pulmonary disease. | 1993 | Respir Med | pmid:7901879 |
| Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
| Fairbairn SM et al. | Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. | 1996 | Res. Vet. Sci. | pmid:8880978 |
| Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
| Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Jarvis GE and Evans RJ | Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro. | 1994 | Res. Vet. Sci. | pmid:7871251 |
| Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Dupuis F et al. | Production and metabolism of platelet-activating factor by human bone marrow cells. | 1997 | Res. Immunol. | pmid:9226766 |
| Denizot Y et al. | Modulation of gut wall paf-acether and precursors by intestinal microflora. | 1990 Mar-Apr | Res. Immunol. | pmid:2218055 |
| Denizot Y et al. | Effects of platelet-activating factor on human T and B cells--an overview. | 1994 | Res. Immunol. | pmid:8079043 |
| Chand N et al. | Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach. | 1994 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:7850258 |
| Ferreira MG and Fonteles MC | Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8987112 |
| Yamawaki I et al. | Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9485521 |
| Osborne JA et al. | In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. | 1986 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3715198 |
| Hoffman DR et al. | Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. | 1984 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6739956 |
| Bloom JW et al. | Intravenous platelet activating factor does not affect lung epithelial permeability. | 1987 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3326081 |
| Chand N et al. | Inhibition of PAF-induced histamine secretion and bronchoconstriction by WEB 2086. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1691522 |
| Janero DR and Burghardt C | Production and release of platelet-activating factor by the injured heart-muscle cell (cardiomyocyte). | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2333409 |
| Hubbard JW et al. | Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. | 1985 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:4059660 |
| Rabovsky J et al. | Platelet-activating factor-induced aggregation of rat alveolar macrophages. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2396044 |
| Nobe K et al. | Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8235067 |
| O'Flaherty JT et al. | Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6844746 |
| Ng DS and Wong K | Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2740622 |
| Misawa M and Chiba Y | Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist). | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7938906 |
| Ng DS and Wong K | Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2557657 |
| Miller LG et al. | Platelet activating factor antagonists interact with GABAA receptors. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1667341 |
| Lyman BA et al. | In vitro and in vivo activities of the novel antiplatelet agent alpha,alpha'-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene dihydrobromide. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1475529 |
| Hillmar I and Zöllner N | Saturated and unsaturated 1-0-alkyl-2-0-acetoyl-sn-glycero-3-phosphocholines and 2-lyso derivatives from ratfish liver oil. Effect on adenosine 3':5'-cyclic monophosphate concentration in hepatocyte suspensions. | 1983 | Res Exp Med (Berl) | pmid:6310713 |
| Felix SB et al. | Effects of platelet-activating factor on beta- and H2-receptor-mediated increase of myocardial contractile force in isolated perfused guinea pig hearts. | 1991 | Res Exp Med (Berl) | pmid:1852056 |
| Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
| Gopichandran N and Leese HJ | The effect of paracrine/autocrine interactions on the in vitro culture of bovine preimplantation embryos. | 2006 | Reproduction | pmid:16452720 |
| Downing SJ et al. | Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? | 2002 | Reproduction | pmid:12361471 |
| Hynes AC et al. | The phosphatidylinositol signalling system in elongating bovine blastocysts; formation of phosphoinositides, inositol phosphates and stimulation by growth factors. | 2002 | Reprod. Fertil. Dev. | pmid:12617797 |
| O'Neill C et al. | Outcome of pregnancies resulting from a trial of supplementing human IVF culture media with platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1585005 |
| Ryan JP et al. | Metabolic and developmental responses of preimplantation embryos to platelet activating factor (PAF). | 1992 | Reprod. Fertil. Dev. | pmid:1461990 |
| Pike IL et al. | Actions of platelet activating factor (PAF) on gametes and embryos: clinical aspects. | 1992 | Reprod. Fertil. Dev. | pmid:1461991 |
| O'Neill C | Embryo-derived platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1438959 |
| Kojima T et al. | Production and secretion of progesterone in vitro and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. | 1993 | Reprod. Fertil. Dev. | pmid:8234890 |
| Dusting GJ and Stewart AG | Overview of eicosanoid metabolism and relationship to platelet-activating factor. | 1990 | Reprod. Fertil. Dev. | pmid:2075239 |
| O'Neill C et al. | Embryo-derived platelet activating factor: interactions with the arachidonic acid cascade and the establishment and maintenance of pregnancy. | 1990 | Reprod. Fertil. Dev. | pmid:2075241 |
| Roberts C et al. | Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos. | 1993 | Reprod. Fertil. Dev. | pmid:8272531 |
| Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
| Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
| Tiemann U | The role of platelet-activating factor in the mammalian female reproductive tract. | 2008 | Reprod. Domest. Anim. | pmid:18363604 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
| Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
| Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
| López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
| Pirotzky E et al. | Platelet-activating factor antagonist, BN-52021 protects against cis-diamminedichloroplatinum nephrotoxicity in the rat. | 1990 | Ren Fail | pmid:2287769 |
| Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
| Wallace JL et al. | Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. | 1993 | Regul. Pept. | pmid:7901873 |
| Iwamoto I et al. | Role of leukotriene B4 in substance P-induced granulocyte infiltration in mouse skin. | 1993 | Regul. Pept. | pmid:7692497 |
| Resetkova E et al. | Effect of human thyroglobulin on the production of platelet activating factor from peripheral blood mononuclear cells from patients with autoimmune thyroid diseases. | 1992 Jul-Aug | Reg Immunol | pmid:1476872 |
| Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
| Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
| Kasperska-Zajac A et al. | Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. | 2008 | Recent Pat Inflamm Allergy Drug Discov | pmid:19075994 |
| Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
| Weintraub ST et al. | Electrospray ionization for analysis of platelet-activating factor. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1841648 |
| Smith JC et al. | Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | 2008 | Rapid Commun. Mass Spectrom. | pmid:18937225 |
| Barnes PJ | The changing face of asthma. | 1987 | Q. J. Med. | pmid:3310071 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
| Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
| Touvay C et al. | Effect of long-term infusion of platelet-activating factor on pulmonary responsiveness and morphology in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1804494 |
| Salari H and Schellenberg RR | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1991 | Pulm Pharmacol | pmid:1804490 |
| Macquin-Mavier I et al. | Effects of platelet-activating factor on lung epithelial permeability in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1806136 |
| Underwood SL et al. | RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. | 1992 | Pulm Pharmacol | pmid:1280178 |
| Lai CK and Holgate ST | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1992 | Pulm Pharmacol | pmid:1591466 |
| Spina D et al. | The role of platelet activating factor in allergic inflammation. | 1989 | Pulm Pharmacol | pmid:2520484 |
| Björck T and Dahlén SE | Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. | 1993 | Pulm Pharmacol | pmid:8477156 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Chomyszyn-Gajewska M | [Evaluation of chosen salivary periodontal disease markers]. | 2010 | Prz. Lek. | pmid:20687387 |
| Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
| Myśliwiec M and Myśliwiec B | [Blood platelets, prostaglandin and complement interactions in inflammation]. | 1982 | Prz. Lek. | pmid:6753039 |
| Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
| Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
| Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
| Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
| Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| Arai H | Platelet-activating factor acetylhydrolase. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432911 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |