Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Diez-Fraile A et al. | Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. | 2004 | Am. J. Vet. Res. | pmid:15524330 |
| Kingston JK et al. | Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. | 2002 | Am. J. Vet. Res. | pmid:11939312 |
| Menzies-Gow NJ et al. | Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. | 2008 | Am. J. Vet. Res. | pmid:18241016 |
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Wilson DV et al. | Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. | 1993 | Am. J. Vet. Res. | pmid:8430938 |
| Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
| Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
| Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
| Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
| Symposium on The Clinical Importance of Leukotrienes and Platelet-activating Factor in Allergic Respiratory Diseases. November 14, 1990, San Francisco, California. | 1991 | Am. Rev. Respir. Dis. | pmid:1673326 | |
| Christman BW et al. | Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep. | 1990 | Am. Rev. Respir. Dis. | pmid:2174655 |
| Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
| Kohrogi H et al. | Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. | 1991 | Am. Rev. Respir. Dis. | pmid:1892304 |
| Thivierge M and Rola-Pleszczynski M | Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. | 1991 | Am. Rev. Respir. Dis. | pmid:1650153 |
| Kaye MG and Smith LJ | Effects of inhaled leukotriene D4 and platelet-activating factor on airway reactivity in normal subjects. | 1990 | Am. Rev. Respir. Dis. | pmid:2183659 |
| Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
| Halonen M et al. | Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. | 1985 | Am. Rev. Respir. Dis. | pmid:3881060 |
| Boschetto P et al. | Corticosteroid inhibition of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2001074 |
| Burhop KE et al. | Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. | 1986 | Am. Rev. Respir. Dis. | pmid:3752711 |
| Stengel PW et al. | Inhaled A23187 produces a preferential sensitization to substance P. | 1993 | Am. Rev. Respir. Dis. | pmid:7678372 |
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| Meade CJ and Heuer H | PAF antagonism as an approach to the treatment of airway hyperreactivity. | 1991 | Am. Rev. Respir. Dis. | pmid:2003696 |
| Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
| Smith LJ | The role of platelet-activating factor in asthma. | 1991 | Am. Rev. Respir. Dis. | pmid:2018248 |
| Perretti F and Manzini S | Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs. | 1993 | Am. Rev. Respir. Dis. | pmid:7692777 |
| Henderson WR | Eicosanoids and platelet-activating factor in allergic respiratory diseases. | 1991 | Am. Rev. Respir. Dis. | pmid:1902069 |
| Kazimierczak W et al. | Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. | 1984 | Am. Rev. Respir. Dis. | pmid:6201094 |
| McMurtry IF and Morris KG | Platelet-activating factor causes pulmonary vasodilation in the rat. | 1986 | Am. Rev. Respir. Dis. | pmid:3094417 |
| Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
| Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
| Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
| Ohar JA et al. | A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2297169 |
| Lohman I and Halonen M | Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. | 1990 | Am. Rev. Respir. Dis. | pmid:2382903 |
| Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
| Caplan MS et al. | Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. | 1990 | Am. Rev. Respir. Dis. | pmid:2252241 |
| Lien DC et al. | Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1546852 |
| Barer GR et al. | Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. | 1989 | Am. Rev. Respir. Dis. | pmid:2817616 |
| Oda M et al. | The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. | 1990 | Am. Rev. Respir. Dis. | pmid:2350088 |
| Nakajima H et al. | CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1362635 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Smith LJ et al. | Mechanism of platelet activating factor-induced bronchoconstriction in humans. | 1988 | Am. Rev. Respir. Dis. | pmid:3195800 |
| Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
| Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
| Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
| Pretolani M et al. | Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2160213 |
| Rubin AH et al. | The bronchoconstrictor properties of platelet-activating factor in humans. | 1987 | Am. Rev. Respir. Dis. | pmid:3314611 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
| Horvath CJ et al. | Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. | 1991 | Am. Rev. Respir. Dis. | pmid:1741548 |
| Lantz RC et al. | The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin. | 1991 | Am. Rev. Respir. Dis. | pmid:2064124 |
| Arnoux B et al. | Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. | 1988 | Am. Rev. Respir. Dis. | pmid:3354991 |
| Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
| Murphy RC and Clay KL | Measurement of platelet-activating factor by physicochemical technique s. | 1987 | Am. Rev. Respir. Dis. | pmid:3300445 |
| Page CP | Mechanisms of hyperresponsiveness: platelet-activating factor. | 1992 | Am. Rev. Respir. Dis. | pmid:1734810 |
| Halonen M et al. | Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. | 1980 | Am. Rev. Respir. Dis. | pmid:7458063 |
| Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
| Tokuyama K et al. | Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2048823 |
| Boschetto P et al. | Effect of antiasthma drugs on microvascular leakage in guinea pig airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2563319 |
| Lansing MW et al. | Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. | 1991 | Am. Rev. Respir. Dis. | pmid:1741541 |
| Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
| Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
| Watson JW et al. | IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. | 1990 | Am. Rev. Respir. Dis. | pmid:2240832 |
| Tocker JE et al. | Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. | 1990 | Am. Rev. Respir. Dis. | pmid:2240843 |
| Kidney JC et al. | Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. | 1993 | Am. Rev. Respir. Dis. | pmid:8420421 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Kuitert LM et al. | Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. | 1993 | Am. Rev. Respir. Dis. | pmid:8420437 |
| Wardlaw AJ et al. | Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. | 1990 | Am. Rev. Respir. Dis. | pmid:2405759 |
| Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
| Gulbenkian AR et al. | Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. | 1990 | Am. Rev. Respir. Dis. | pmid:2117872 |
| Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |
| Adam K and Oswald I | [Triazolam is different: it is a PAF antagonist]. | 1992 | Anaesthesist | pmid:1562092 |
| Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
| Balazy M et al. | Determination of platelet-activating factor and alkyl-ether phospholipids by gas chromatography-mass spectrometry via direct derivatization. | 1991 | Anal. Biochem. | pmid:1888023 |
| Ekholm J et al. | The human platelet as a reproducible and sensitive cell for the detection and assay of platelet-activating factor. | 1992 | Anal. Biochem. | pmid:1514698 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
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| Rao GH | Measurement of ionized calcium in normal human blood platelets. | 1988 | Anal. Biochem. | pmid:3382012 |
| Mita H et al. | Quantitation of platelet-activating factor by high-performance liquid chromatography with fluorescent detection. | 1989 | Anal. Biochem. | pmid:2817335 |
| Boyle T et al. | Method for simultaneous isolation and quantitation of platelet activating factor and multiple arachidonate metabolites from small samples: analysis of effects of Staphylococcus aureus enterotoxin B in mice. | 1994 | Anal. Biochem. | pmid:8179192 |
| Oda Y et al. | Quantitation of platelet-activating factor in biological samples using liquid chromatography/mass spectrometry with column-switching technique. | 1995 | Anal. Biochem. | pmid:8678293 |
| Bossant MJ et al. | Quantitation of paf-acether by release of endogenous platelet serotonin assessed by liquid chromatography with electrochemical detection. | 1989 | Anal. Biochem. | pmid:2610359 |
| Sanz-Vicente I et al. | Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | 2017 | Anal. Biochem. | pmid:27956151 |
| Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
| Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
| Nikolelis DP and Siontorou CG | Ammonium ion minisensors form self-assembled bilayer lipid membranes using gramicidin as an ionophore. Modulation of ammonium selectivity by platelet-activating factor. | 1996 | Anal. Chem. | pmid:8651482 |
| Weintraub ST et al. | Synthesis of pentafluorobenzoic anhydride: a superior derivatizing agent for lipids. | 1993 | Anal. Chem. | pmid:8238933 |
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| Ohyama T et al. | Sensitive densitometry for the determination of platelet-activating factor and other phospholipids in human tears. | 1996 | Analyst | pmid:9008409 |
| Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |
| Lebedeva RN et al. | [The status of the receptor-controlled calcium metabolism of the thrombocytes in patients in the early postoperative period]. | 1991 Sep-Oct | Anesteziol Reanimatol | pmid:1767948 |
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| Ereth MH et al. | Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass? | 1997 | Anesth. Analg. | pmid:9249097 |
| Goldsmith JA et al. | Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung. | 1996 | Anesth. Analg. | pmid:8694300 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Hu G et al. | Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels. | 2002 | Anesth. Analg. | pmid:11916783 |
| Habazettl H et al. | Pulmonary hypertension after heparin-protamine: roles of left-sided infusion, histamine, and platelet-activating factor. | 1990 | Anesth. Analg. | pmid:2240637 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |