Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abe Y et al. | Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model. | 2002 | Eur. J. Pharmacol. | pmid:12445578 |
| Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
| Lacombe J et al. | Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides. | 2002 | Can. J. Physiol. Pharmacol. | pmid:12450061 |
| Roy Baker R and Chang Hy | MgATP may depress de novo neuronal nuclear PAF generation by promoting the formation of alkylacylglycerophosphate, an inhibitor of alkylglycerophosphate acetyltransferase. | 2002 | Biochim. Biophys. Acta | pmid:12457714 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| Huang JB et al. | Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470617 |
| Pan YH et al. | Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. | 2002 | Biochemistry | pmid:12475227 |
| Smith JM et al. | Platelet-activating factor and Escherichia coliO157:H7 infections. | 2002 | Pediatr. Nephrol. | pmid:12478356 |
| Makhija R and Kingsnorth AN | Cytokine storm in acute pancreatitis. | 2002 | J Hepatobiliary Pancreat Surg | pmid:12483260 |
| Kulikov VI and Muzya GI | Influence of acyl and plasmalogenic analogs of platelet activating factor on chemotaxis of human leukocytes in vitro and their inflammatory and antiinflammatory activity in vivo. | 2002 | Biochemistry Mosc. | pmid:12495421 |
| Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
| Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
| Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
| Zhang Y et al. | Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor. | 2003 | J. Soc. Gynecol. Investig. | pmid:12517587 |
| Wang WJ et al. | [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525061 |
| Handa RK et al. | Platelet-activating factor and solute transport processes in the kidney. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12529272 |
| Zhao H et al. | Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. | 2003 | World J. Gastroenterol. | pmid:12532462 |
| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
| Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |
| Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
| Farmer PJ et al. | Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin. | 2002 | Inflammation | pmid:12546134 |
| Jin Y et al. | [The effect of autocrine factors on development of early embryos of mouse]. | 2001 | Shi Yan Sheng Wu Xue Bao | pmid:12549014 |
| Wang R et al. | [High performance thin layer chromatographic (HPTLC) determination of PAF in cerebrospinal fluid of patients with subarachnoid hemorrhage(SAH)]. | 1999 | Se Pu | pmid:12552702 |
| Lee JM et al. | Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. | 2003 | J. Biol. Chem. | pmid:12556532 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Kolko M et al. | Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. | 2003 | Neurosci. Lett. | pmid:12566178 |
| Vogensen SB et al. | Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. | 2003 | J. Med. Chem. | pmid:12570381 |
| Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
| Balestrieri ML et al. | Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. | 2003 | J. Lipid Res. | pmid:12576520 |
| Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |
| Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
| Gabbianelli R et al. | A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts. | 2003 | Clin. Chim. Acta | pmid:12589971 |
| Chłopicki S et al. | Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. | 2002 Sep-Oct | Pol J Pharmacol | pmid:12593530 |
| Biffl WL et al. | Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. | 2001 | Surg Infect (Larchmt) | pmid:12593704 |
| Casillan AJ et al. | Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. | 2003 | J. Appl. Physiol. | pmid:12598480 |
| D'Andrea G et al. | Platelet aggregation profiles in cluster headache. | 2003 | Headache | pmid:12603647 |
| Gruska S et al. | Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease. | 2003 | Clin. Sci. | pmid:12605593 |
| Lu DP et al. | Ligand-activated signal transduction in the 2-cell embryo. | 2003 | Biol. Reprod. | pmid:12606379 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Hynes AC et al. | The phosphatidylinositol signalling system in elongating bovine blastocysts; formation of phosphoinositides, inositol phosphates and stimulation by growth factors. | 2002 | Reprod. Fertil. Dev. | pmid:12617797 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Ueyama Y et al. | Effects of bile acids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced aberrant crypt foci and DNA adduct formation in the rat colon. | 2002 | J. Exp. Clin. Cancer Res. | pmid:12636105 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
| Shigematsu S et al. | Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. | 2003 | Free Radic. Biol. Med. | pmid:12654468 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
| Guan Z et al. | [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. | 2000 | Wei Sheng Yan Jiu | pmid:12725051 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Marshall JC | Such stuff as dreams are made on: mediator-directed therapy in sepsis. | 2003 | Nat Rev Drug Discov | pmid:12750742 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Kusunoki H et al. | Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. | 2003 | Diabetes Care | pmid:12766129 |
| Strümper D et al. | Effects of antidepressants on function and viability of human neutrophils. | 2003 | Anesthesiology | pmid:12766643 |
| Pizurki L et al. | Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. | 2003 | Br. J. Pharmacol. | pmid:12770938 |
| Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
| Denizot Y et al. | No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. | 2003 | Mediators Inflamm. | pmid:12775360 |
| Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
| Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
| Sugimoto Y et al. | Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. | 2003 | Int. Immunopharmacol. | pmid:12781701 |
| Fragopoulou E et al. | Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. | 2003 | Biochim. Biophys. Acta | pmid:12782155 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Boughton-Smith NK et al. | Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. | 1992 | Agents Actions | pmid:1279960 |
| Hashimoto T et al. | [Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs]. | 1992 | Arerugi | pmid:1280089 |
| Underwood SL et al. | RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. | 1992 | Pulm Pharmacol | pmid:1280178 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Vleeming W et al. | Modulation of antigen- and ischemia-induced effects by the platelet-activating factor antagonist WEB-2086 in isolated sensitized rat hearts. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1280743 |
| Fernandes LB and Goldie RG | The single mediator approach to asthma therapy: is it so unreasonable? | 2003 | Curr Opin Pharmacol | pmid:12810188 |
| Watanabe J et al. | Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. | 2003 | J. Biol. Chem. | pmid:12810708 |
| Toledo AA et al. | Fertilization potential of human sperm is correlated with endogenous platelet-activating factor content. | 2003 | J. Assist. Reprod. Genet. | pmid:12812462 |
| Souza DG et al. | Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. | 2003 | Br. J. Pharmacol. | pmid:12812996 |
| Brown RA et al. | Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. | 2003 | Br. J. Pharmacol. | pmid:12813008 |
| Abu-Zidan FM | Comment on "Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss". | 2003 | J Trauma | pmid:12813357 |
| Toledo DP et al. | Microvascular reactivity in experimental diabetes: responses of male and female rats. | 2003 | Inflamm. Res. | pmid:12813623 |
| Hellewell PG et al. | Inflammatory mechanisms in the passive cutaneous anaphylactic reaction in the rabbit: evidence that novel mediators are involved. | 1992 | Br. J. Pharmacol. | pmid:1281720 |
| Sugimoto T et al. | Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281995 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Black SC et al. | Inhibition of platelet-activating factor fails to limit ischemia and reperfusion-induced myocardial damage. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282605 |
| Sagach VF et al. | Endothelium-dependent effects of platelet-activating factor in the coronary circulation. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282996 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Fernandes ES et al. | Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. | 2003 | Br. J. Pharmacol. | pmid:12839871 |
| Neumann FJ et al. | Effect of gallopamil on neutrophil function: experimental and clinical studies. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1284152 |
| Saruc M et al. | An experimental model of hemolysis-induced acute pancreatitis. | 2003 | Braz. J. Med. Biol. Res. | pmid:12845374 |