| MeSH term | MeSH ID | Detail |
|---|---|---|
| Behcet Syndrome | D001528 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Arteriosclerosis Obliterans | D001162 | 8 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Arthus Reaction | D001183 | 8 associated lipids |
| Peripheral Vascular Diseases | D016491 | 8 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu X et al. | A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. | 2000 | J. Immunol. Methods | pmid:10854610 |
| Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
| Nakajima T et al. | Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. | 2000 | Int. J. Biochem. Cell Biol. | pmid:10856708 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
| Hu L et al. | Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity. | 2000 | Bioorg. Med. Chem. | pmid:10896127 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Unno N et al. | Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan. | 2000 | J. Vasc. Surg. | pmid:10917985 |
| Ruchaud-Sparagano MH et al. | Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization. | 2000 | J. Biol. Chem. | pmid:10748085 |
| Henderson WR et al. | Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. | 2000 | J. Immunol. | pmid:10706731 |
| Zouki C et al. | The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. | 2000 | FASEB J. | pmid:10698973 |
| Tu W et al. | [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372382 |
| Nikbakht-Sangari M et al. | The role of inflammatory mediators in the mechanism of the host immune response induced by ischemia-reperfusion injury. | 2000 | Immunol. Invest. | pmid:10709843 |
| Turner PJ et al. | Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10711351 |
| Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
| McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
| Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
| Cowling RT and Birnboim HC | Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. | 2000 | J. Leukoc. Biol. | pmid:10670586 |
| Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
| Werr J et al. | Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. | 2000 | Blood | pmid:10688841 |
| Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
| Bleeker WK et al. | Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. | 2000 | Blood | pmid:10688848 |
| Weintraub ST et al. | Mass spectrometric analysis of platelet-activating factor after isolation by solid-phase extraction and direct derivatization with pentafluorobenzoic anhydride. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689672 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Keularts IM et al. | alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. | 2000 | J. Biol. Chem. | pmid:10636873 |
| Tong N et al. | Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. | 2000 | J. Immunol. | pmid:10640747 |
| Clavijo LC et al. | Platelet-activating factor and bacteremia-induced pulmonary hypertension. | 2000 | J. Surg. Res. | pmid:10644485 |
| Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
| Ibe BO et al. | Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. | 2000 | Mol. Genet. Metab. | pmid:10655157 |
| Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Hashimoto S et al. | p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10606930 |
| Tokumura A et al. | Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. | 2000 | Biofactors | pmid:11237195 |
| Tan XD et al. | Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. | 2000 | Br. J. Pharmacol. | pmid:10742310 |
| Wiese A et al. | Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity. | 2000 | Biol. Chem. | pmid:10746745 |
| Howard KM and Olson MS | The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. | 2000 | J. Biol. Chem. | pmid:10748027 |
| Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
| Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Asai Y et al. | A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements. | 2000 | Drug Dev Ind Pharm | pmid:10789068 |
| Balsinde J et al. | Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. | 2000 | J. Immunol. | pmid:10799904 |
| Dearn S et al. | Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. | 2000 | Mol. Med. | pmid:10803407 |
| Kosaka T et al. | Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | 2000 | Clin. Chim. Acta | pmid:10807978 |
| Triggiani M et al. | Metabolism of lipid mediators in human eosinophils. | 2000 | Chem. Immunol. | pmid:10761306 |
| Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
| Emerson M et al. | Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor. | 2000 | J. Biol. Chem. | pmid:10764773 |
| Yoshimatsu Y et al. | Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells. | 2000 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:11074135 |
| Walther A et al. | Role of platelet-activating factor in leukocyte-independent plasma extravasation and mast cell activation during endotoxemia. | 2000 | J. Surg. Res. | pmid:11027469 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| Porta C et al. | Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. | 2000 | Haematologica | pmid:10942928 |
| De Geest B et al. | Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11031226 |
| McLarnon JG et al. | Anion channels modulate store-operated calcium influx in human microglia. | 2000 | Cell Calcium | pmid:11032781 |
| Fraga AG et al. | Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists. | 2000 | Eur J Pharm Sci | pmid:11033071 |
| Choi SY et al. | Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. | 2000 | J. Immunol. | pmid:11034409 |
| Simon HU et al. | Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. | 2000 | J. Immunol. | pmid:11034418 |
| Rowland BL et al. | Elevated circulating concentrations of platelet activating factor in preeclampsia. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035340 |
| Li N et al. | Platelet-leukocyte cross talk in whole blood. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116075 |
| Le Blanc K et al. | Defective platelet aggregation in polycythaemia vera is not caused by impaired calcium signaling, phospholipase D activation or decreased amounts of focal adhesion proteins. | 2000 | Eur. J. Haematol. | pmid:11092463 |
| Iwamoto H et al. | Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:11119873 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
| Durán WN et al. | Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. | 2000 | Microvasc. Res. | pmid:10964584 |
| Wereszczynska-Siemiatkowska U et al. | Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect. | 2000 | Exp. Toxicol. Pathol. | pmid:10965985 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Suzuki T et al. | Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. | 2000 | Eur. J. Pharmacol. | pmid:10988347 |
| Kallan NC and Halcomb RL | Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. | 2000 | Org. Lett. | pmid:10990428 |
| Turner PJ et al. | Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10991932 |
| Gastaldello K et al. | Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. | 2000 | Nephrol. Dial. Transplant. | pmid:11007834 |
| Wratten ML et al. | Hemolipodialysis attenuates oxidative stress and removes hydrophobic toxins. | 2000 | Artif Organs | pmid:11012537 |
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| Bailey SR et al. | Differential activation of platelets from normal and allergic ponies by PAF and ADP. | 2000 | Inflamm. Res. | pmid:10893045 |
| Kobayashi Y et al. | [Inhibitory effect of suplatast tosilate on eosinophil migration]. | 2000 | Arerugi | pmid:10944827 |
| Liu JK et al. | Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10945272 |
| Ueda T et al. | Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. | 2000 | J. Surg. Res. | pmid:10945960 |
| Marathe GK et al. | Bioactive phospholipid oxidation products. | 2000 | Free Radic. Biol. Med. | pmid:10946218 |
| Zhuang Q et al. | Activation via multiple signaling pathways induces down-regulation of platelet-activating factor receptors on human B lymphocytes. | 2000 | J. Immunol. | pmid:10946267 |
| Davenpeck KL et al. | Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. | 2000 | J. Immunol. | pmid:10946308 |
| Wilks J | The impact of the pill on implantation factors--new research findings. | 2000 | Ethics Med | pmid:15015518 |
| Denizot Y et al. | Deregulated platelet-activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy. | 2000 | Nephrol. Dial. Transplant. | pmid:10978389 |
| Clark WF et al. | A novel treatment for lupus nephritis: lignan precursor derived from flax. | 2000 | Lupus | pmid:10981647 |
| Klabunde RE and Anderson DE | Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakage. | 2000 | Eur. J. Pharmacol. | pmid:10996604 |
| Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
| Nieswandt B et al. | Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. | 2000 | Blood | pmid:11001906 |
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| Taguchi R et al. | Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. | 2000 | J Mass Spectrom | pmid:10972995 |
| Clark GD et al. | Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. | 2000 | Neurochem. Res. | pmid:10905621 |
| Wang JH and Sun GY | Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). | 2000 | Neurochem. Res. | pmid:10905622 |
| Baker RR | Lipid acetylation reactions and the metabolism of platelet-activating factor. | 2000 | Neurochem. Res. | pmid:10905630 |
| Francescangeli E et al. | Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. | 2000 | Neurochem. Res. | pmid:10905633 |
| Viswanath M et al. | Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection. | 2000 | Pediatr. Res. | pmid:10879808 |
| Zhu W et al. | Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs. | 2000 | Chin. Med. J. | pmid:11776064 |
| Wagner F et al. | Ether lipids in the cell membrane of Mycoplasma fermentans. | 2000 | Eur. J. Biochem. | pmid:11012682 |
| Klyubin IV et al. | The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes. | 2000 | Membr Cell Biol | pmid:10926373 |
| Roudebush WE and Purnell ET | Platelet-activating factor content in human spermatozoa and pregnancy outcome. | 2000 | Fertil. Steril. | pmid:10927041 |
| Matsunaga Y et al. | Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction. | 2000 | Br. J. Pharmacol. | pmid:10928955 |
| Capasso R et al. | Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. | 2000 | Fitoterapia | pmid:10930724 |
| Xu H et al. | Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. | 2000 | Am. J. Kidney Dis. | pmid:10873870 |