Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Spasm D013035 5 associated lipids
Sneezing D012912 6 associated lipids
Shock, Traumatic D012774 4 associated lipids
Shock, Septic D012772 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Zhao YM and Maimone TJ Short, enantioselective total synthesis of chatancin. 2015 Angew. Chem. Int. Ed. Engl. pmid:25470723
Kattan JD and Sicherer SH Optimizing the diagnosis of food allergy. 2015 Immunol Allergy Clin North Am pmid:25459577
Zelanis A et al. Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. 2015 J Proteomics pmid:25452133
Larkin EK et al. New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. 2015 Am. J. Respir. Crit. Care Med. pmid:25408961
Kooijman S et al. Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. 2015 J. Thromb. Haemost. pmid:25345495
Detopoulou P et al. The relation of diet with PAF and its metabolic enzymes in healthy volunteers. 2015 Eur J Nutr pmid:24639073
Starossom SC et al. Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. 2015 Circ. Res. pmid:26294656
Morita K et al. [Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model]. 2015 Nippon Yakurigaku Zasshi pmid:26256746
Plotkowski MC et al. Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa. 2015 Pathog Dis pmid:26187894
Sato A et al. Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors. 2015 Eur. J. Pharmacol. pmid:26142829
Sala-Cunill A and Cardona V Biomarkers of anaphylaxis, beyond tryptase. 2015 Curr Opin Allergy Clin Immunol pmid:26110683
Gao L et al. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. 2015 J. Clin. Invest. pmid:26098214
Jiao D et al. Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. 2014 May-Jun Cell. Immunol. pmid:24751884
Yamauchi A et al. Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. 2014 J. Immunol. Methods pmid:24370750
Sahu RP et al. Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. 2014 Cancer Res. pmid:25304264
Yu Y et al. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. 2014 J. Exp. Clin. Cancer Res. pmid:25261977
Agrawal V et al. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. 2014 Biol. Reprod. pmid:25253732
Moschos MM et al. In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. 2014 Cutan Ocul Toxicol pmid:24147947
Chacón-Salinas R et al. An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. 2014 J. Leukoc. Biol. pmid:24009177
Semini G et al. Glycosidated phospholipids - a promising group of anti-tumour lipids. 2014 Anticancer Agents Med Chem pmid:24628240