Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Munoz-Cano R et al. | Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study). | 2017 | J Investig Allergol Clin Immunol | pmid:27758758 |
Moschos MM et al. | Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets. | 2017 | Drug Des Devel Ther | pmid:28458520 |
Gale TV et al. | Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. | 2017 | PLoS Negl Trop Dis | pmid:28922385 |
Larrazabal CS et al. | Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. | 2017 | Vet. Immunol. Immunopathol. | pmid:28895869 |
Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |
Lecewicz M et al. | Effects of the platelet-activating factor (PAF) supplementation on ATP content of cryopreserved bull spermatozoa (AI). | 2017 | Pol J Vet Sci | pmid:28865217 |
Wang H et al. | Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2-year follow-up in China: An observational cohort study. | 2017 | Medicine (Baltimore) | pmid:28816946 |
Smith LJ | Leukotrienes and sex: strange bedfellows? | 2017 | J. Clin. Invest. | pmid:28737507 |
Lukic A et al. | GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures. | 2017 | FASEB J. | pmid:28637652 |
Xanthopoulou MN et al. | Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men. | 2017 | Eur J Nutr | pmid:26936842 |
Kispert S et al. | Cigarette Smoke Regulates Calcium-Independent Phospholipase A Metabolic Pathways in Breast Cancer. | 2017 | Am. J. Pathol. | pmid:28618256 |
Kelly AM et al. | The effect of variation in donor platelet function on transfusion outcome: a semirandomized controlled trial. | 2017 | Blood | pmid:28487294 |
Meyer AF et al. | Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. | 2017 | Biochim. Biophys. Acta | pmid:28472616 |
Malavige GN and Ogg GS | Pathogenesis of vascular leak in dengue virus infection. | 2017 | Immunology | pmid:28437586 |
Shindou H et al. | Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. | 2017 | FASEB J. | pmid:28341636 |
Kispert SE et al. | Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. | 2017 | Physiol Rep | pmid:28270596 |
Noh KT et al. | Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. | 2017 | J. Biol. Chem. | pmid:28077574 |
Liao YR et al. | Bioactive chemical constituents from the root bark of Morus australis. | 2017 | Bioorg. Med. Chem. Lett. | pmid:27908762 |
Sanz-Vicente I et al. | Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | 2017 | Anal. Biochem. | pmid:27956151 |
Palur Ramakrishnan AV et al. | Platelet activating factor: A potential biomarker in acute coronary syndrome? | 2017 | Cardiovasc Ther | pmid:27790832 |
Borges AF et al. | Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. | 2017 | Pathog Dis | pmid:28830073 |
Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |
Ren J et al. | Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. | 2018 | Acta Cir Bras | pmid:29412230 |
Shi K et al. | Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma. | 2018 | Cancer Sci. | pmid:29436067 |
Hasegawa A et al. | Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29269296 |
Zhang X et al. | Serum metabolomics of laryngeal cancer based on liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | 2018 | Biomed. Chromatogr. | pmid:29272549 |