| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Salmonella Infections, Animal | D012481 | 9 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Stomatitis | D013280 | 14 associated lipids |
| Subacute Sclerosing Panencephalitis | D013344 | 3 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Joly F et al. | Ketotifen inhibits paf-acether biosynthesis and beta-hexosaminidase release in mouse mast cells stimulated with antigen. | 1987 | Eur. J. Pharmacol. | pmid:2963750 |
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
| Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
| Smallbone BW et al. | Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2821222 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
| Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
| Gordeev KIu et al. | [Synthesis of 1-(1-alkenyl)-2-acetyl-sn-glycero-3-phosphocholines, the aldehyded analogs of platelet activating factor]. | 1987 | Bioorg. Khim. | pmid:3566815 |
| Davenas E et al. | Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. | 1987 | Eur. J. Pharmacol. | pmid:3034632 |
| Stahl GL and Lefer AM | Heterogeneity of vascular smooth muscle responsiveness to lipid vasoactive mediators. | 1987 | Blood Vessels | pmid:3567363 |
| Sigal CE et al. | Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC). | 1987 | J. Clin. Immunol. | pmid:3571436 |
| Godfroid JJ et al. | Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity. | 1987 | J. Med. Chem. | pmid:3572968 |
| Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
| Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
| Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
| Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
| Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
| Dejana E et al. | Modulation of endothelial cell functions by different molecular species of interleukin 1. | 1987 | Blood | pmid:3542082 |
| Lucchesi BR et al. | Interaction of the formed elements of blood with the coronary vasculature in vivo. | 1987 | Fed. Proc. | pmid:3542578 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. | 1987 | J. Biol. Chem. | pmid:3549727 |
| Nunez D et al. | [Effects of SIN-1, a metabolite of molsidomine, on paf-acether-blood platelets interactions]. | 1987 | Pathol. Biol. | pmid:3550639 |
| Chang SW et al. | Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. | 1987 | J. Clin. Invest. | pmid:3553241 |
| Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
| Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
| Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
| Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
| Tokumura A et al. | Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593346 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in platelet aggregation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593379 |
| Lapointe DS et al. | Mobilization of hepatic calcium pools by platelet activating factor. | 1987 | Biochemistry | pmid:3593678 |
| Fujita K et al. | Synthesis and biological activity of fluorine-modified platelet activating factors. | 1987 | Chem. Pharm. Bull. | pmid:3594676 |
| O'Neill C et al. | Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos. | 1987 | Fertil. Steril. | pmid:3595903 |
| Etienne A et al. | Inhibition of rat endotoxin-induced lethality by BN 52021 and BN 52063, compounds with PAF-acether antagonistic effect and protease-inhibitory activity. | 1987 | Int J Tissue React | pmid:3596954 |
| Doly M et al. | Effects of PAF-acether on electrophysiological response of isolated retina. | 1987 | Int J Tissue React | pmid:3596955 |
| Purdon AD et al. | Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3100454 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
| Oon SH and Williams N | Immature megakaryocytes in the mouse: synergistic response to megakaryocyte potentiator, thrombopoietic stimulatory factor with interleukin 3. | 1987 | Leukemia | pmid:3500375 |
| Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
| Pretolani M et al. | Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs. | 1987 | Eur. J. Pharmacol. | pmid:3653247 |
| O'Donnell SR and Barnett CJ | Microvascular leakage to platelet activating factor in guinea-pig trachea and bronchi. | 1987 | Eur. J. Pharmacol. | pmid:3040440 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Okayasu T et al. | Platelet-activating factor stimulates metabolism of phosphoinositides via phospholipase A2 in primary cultured rat hepatocytes. | 1987 | J. Lipid Res. | pmid:3040878 |
| Deguchi K et al. | [Platelet activating factor]. | 1987 | Nippon Rinsho | pmid:3041069 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Hurst JS et al. | Effects of the lipid peroxidation product 4-hydroxynonenal on the aggregation of human platelets. | 1987 | Chem. Biol. Interact. | pmid:3103933 |
| Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Morganroth ML et al. | Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. | 1987 | Prostaglandins | pmid:3108962 |
| Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| Wallace JL et al. | Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. | 1987 | Gastroenterology | pmid:3305134 |
| Barnes PJ | The changing face of asthma. | 1987 | Q. J. Med. | pmid:3310071 |
| Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
| Makowka L et al. | Prolongation of pig-to-dog renal xenograft survival by modification of the inflammatory mediator response. | 1987 | Ann. Surg. | pmid:3310931 |
| Hanahan DJ and Kumar R | Platelet activating factor; chemical and biochemical characteristics. | 1987 | Prog. Lipid Res. | pmid:3313430 |
| Pignol B et al. | Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes. | 1987 | Prostaglandins | pmid:3313526 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
| Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
| Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
| Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
| Camussi G et al. | Release of platelet-activating factor from rabbit heart perfused in vitro by sera with transplantation alloantibodies. | 1987 | Transplantation | pmid:3299910 |
| Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
| Murphy RC and Clay KL | Measurement of platelet-activating factor by physicochemical technique s. | 1987 | Am. Rev. Respir. Dis. | pmid:3300445 |
| Braquet P et al. | Perspectives in platelet-activating factor research. | 1987 | Pharmacol. Rev. | pmid:3303066 |
| Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
| Murphy WG et al. | Relationship between platelet aggregating factor and von Willebrand factor in thrombotic thrombocytopenic purpura. | 1987 | Br. J. Haematol. | pmid:3499167 |
| Suemune H et al. | Asymmetric synthesis of (+)- and (-)-batyl alcohol, a key synthetic intermediate for platelet-activating factor, by using biocatalysts. | 1987 | Chem. Pharm. Bull. | pmid:3427701 |
| Shimazaki N et al. | Diketopiperazine derivatives, a new series of platelet-activating factor inhibitors. | 1987 | Chem. Pharm. Bull. | pmid:3427732 |
| Lang CH et al. | Attenuation of endotoxin-induced increase in glucose metabolism by platelet-activating factor antagonist. | 1987 | Circ. Shock | pmid:3427772 |
| Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
| Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
| Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
| Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
| Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
| Morley J and Sanjar S | PAF, ketotifen and asthma. | 1987 | N. Z. Med. J. | pmid:3468405 |
| Abramovici Y et al. | Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment. | 1987 | Acta Endocrinol Suppl (Copenh) | pmid:3475908 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Doebber TW and Wu MS | Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3478712 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Satouchi K et al. | 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. | 1987 | Lipids | pmid:3110532 |