| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Salmonella Infections, Animal | D012481 | 9 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Stomatitis | D013280 | 14 associated lipids |
| Subacute Sclerosing Panencephalitis | D013344 | 3 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arnoux B et al. | Effect of PAF-acether in non-human primates. | 1988 | Prog. Clin. Biol. Res. | pmid:2837781 |
| Hecker G et al. | Potent inhibition of PAF-stimulated human platelets and polymorphonuclear leukocytes by the PGE1 analog OP-1206. | 1987 | Prog. Clin. Biol. Res. | pmid:2444988 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Stjernschantz J and Bito LZ | The ocular effects of eicosanoids and other autacoids: historic background and the need for a broader perspective. | 1989 | Prog. Clin. Biol. Res. | pmid:2571999 |
| Valone FH et al. | Mechanisms for biphasic or persistent immunologic reactions induced by platelet-activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2685826 |
| Piper PJ and Yaacob HB | Interactions of platelet activating factor, thromboxane A2 and leukotrienes in guinea-pig heart. | 1989 | Prog. Clin. Biol. Res. | pmid:2508116 |
| Gasser H et al. | Effect of platelet-activating factor (PAF) administration in chronically instrumented sheep--analysis of PAF in plasma. | 1989 | Prog. Clin. Biol. Res. | pmid:2780708 |
| Bonavida B et al. | The involvement of platelet-activating factor (PAF)-induced monocyte activation and tumor necrosis factor (TNF) production in shock. | 1989 | Prog. Clin. Biol. Res. | pmid:2780710 |
| Heuer H | Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity. | 1989 | Prog. Clin. Biol. Res. | pmid:2780739 |
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| Camussi G et al. | Anti-inflammatory peptides inhibit synthesis of platelet-activating factor. | 1990 | Prog. Clin. Biol. Res. | pmid:2204939 |
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| Bradley LM et al. | The role of lipid mediators in hypoxic pulmonary vasoconstriction in newborns. | 1989 | Prog. Clin. Biol. Res. | pmid:2798449 |
| Baker RC | Ethanol modulation of the effects of platelet-activating factor on human platelets and a macrophage cell line. | 1990 | Prog. Clin. Biol. Res. | pmid:2300602 |
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| Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
| Schirmer WJ et al. | Systemic and renal hemodynamic response to platelet activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2726980 |
| Dhainaut JF et al. | Platelet-activating factor antagonists as therapeutic strategy in sepsis. | 1994 | Prog. Clin. Biol. Res. | pmid:7831364 |
| Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
| Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
| Ishii S and Shimizu T | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. | 2000 | Prog. Lipid Res. | pmid:10729607 |
| Whatley RE et al. | Lipid metabolism and signal transduction in endothelial cells. | 1990 | Prog. Lipid Res. | pmid:2128404 |
| Itabe H | Oxidized phospholipids as a new landmark in atherosclerosis. | 1998 Jul-Aug | Prog. Lipid Res. | pmid:9829125 |
| Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Frenkel RA et al. | The biochemical role of platelet-activating factor in reproduction. | 1996 | Prog. Lipid Res. | pmid:8944225 |
| Snyder F et al. | The role of transacylases in the metabolism of arachidonate and platelet activating factor. | 1992 | Prog. Lipid Res. | pmid:1641397 |
| Tokumura A | A family of phospholipid autacoids: occurrence, metabolism and bioactions. | 1995 | Prog. Lipid Res. | pmid:7480064 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Hanahan DJ and Kumar R | Platelet activating factor; chemical and biochemical characteristics. | 1987 | Prog. Lipid Res. | pmid:3313430 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Damiani E and Ullrich SE | Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. | 2016 | Prog. Lipid Res. | pmid:27073146 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Maclennan KM et al. | Platelet-activating factor in the CNS. | 1996 | Prog. Neurobiol. | pmid:9015828 |
| Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Montrucchio G et al. | In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. | 1986 | Prostaglandins | pmid:3797692 |
| McCulloch RK and Vandongen R | Mechanisms of platelet activating factor-induced aggregation and secretion in human platelets. | 1990 | Prostaglandins | pmid:2106712 |
| Silver RK et al. | Acetylsalicylic acid inhibits anticardiolipin antibody-induced platelet-activating factor (PAF) synthesis. | 1993 | Prostaglandins | pmid:8430224 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Stratton MD et al. | The effect of Clostridium difficile toxin on colonocyte prostanoid activity. | 1994 | Prostaglandins | pmid:7892508 |
| Bussolino F and Camussi G | Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. | 1980 | Prostaglandins | pmid:6258196 |
| Silver RK et al. | Amniotic fluid platelet-activating factor (PAF) is elevated in patients with tocolytic failure and preterm delivery. | 1992 | Prostaglandins | pmid:1542743 |
| Cucala M et al. | Central regulation of gastric acid secretion by platelet-activating factor in anesthesized rats. | 1989 | Prostaglandins | pmid:2499013 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Levine L | Actions of vanadate on arachidonic acid metabolism by cells in culture. | 1991 | Prostaglandins | pmid:2020748 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Boughton-Smith NK et al. | Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. | 1989 | Prostaglandins | pmid:2506613 |
| Levine L | Effects of okadaic acid on agonist-stimulated PGI2 production by rat liver cells (the C-9 cell line). | 1991 | Prostaglandins | pmid:1647047 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| Kaminski DL et al. | Studies on the etiology of acute acalculous cholecystitis: the effect of lipopolysaccharide on human gallbladder mucosal cells. | 1994 | Prostaglandins | pmid:8041874 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Kim CJ et al. | Eosinophils recruited to the lung by segmental antigen challenge show a reduced chemotactic response to leukotriene B4. | 1994 | Prostaglandins | pmid:8066187 |
| Goldenberg MM and Meurer RD | A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat. | 1984 | Prostaglandins | pmid:6505225 |
| Whatley RE et al. | Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells. | 1992 | Prostaglandins | pmid:1546171 |
| Satoh K et al. | Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. | 1988 | Prostaglandins | pmid:3399678 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Jager GV et al. | Antagonist of platelet-activating factor prevents prostaglandin E2 induced ocular hypertension in rabbits. | 1993 | Prostaglandins | pmid:8424134 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Orevi M et al. | A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinalis. | 1992 | Prostaglandins | pmid:1584997 |
| Qu X et al. | Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. | 1996 | Prostaglandins | pmid:8935185 |
| Yue TL et al. | Pharmacologic profile of BN 50739, a new PAF antagonist in vitro and in vivo. | 1990 | Prostaglandins | pmid:2353116 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Pignol B et al. | Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes. | 1987 | Prostaglandins | pmid:3313526 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Young JM et al. | Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. | 1985 | Prostaglandins | pmid:4081060 |
| Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. | 1985 | Prostaglandins | pmid:4081064 | |
| Slama H et al. | Metabolism of arachidonic acid by caruncular and allantochorionic tissues in cows with retained fetal membranes (RFM). | 1993 | Prostaglandins | pmid:8380936 |
| Turner-Gomes SO et al. | Effect of ambient oxygen changes on platelet activating factor production by fetal ovine endothelial cells. | 1991 | Prostaglandins | pmid:1862226 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Myers SI et al. | Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. | 1995 | Prostaglandins | pmid:8588069 |
| Spinnewyn B et al. | Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. | 1987 | Prostaglandins | pmid:3432553 |
| Armstrong RA et al. | Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. | 1985 | Prostaglandins | pmid:2988022 |
| Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
| Kioumis I et al. | Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. | 1988 | Prostaglandins | pmid:3237997 |
| Sirois MG et al. | PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | 1988 | Prostaglandins | pmid:3238010 |
| Voelkel NF et al. | PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. | 1986 | Prostaglandins | pmid:3024235 |
| Braquet M et al. | Leukocytic functions in burn-injured patients. | 1985 | Prostaglandins | pmid:2989978 |
| Bonnet J et al. | Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig. | 1983 | Prostaglandins | pmid:6419289 |
| Fernandes AJ et al. | Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. | 1991 | Prostaglandins | pmid:1801060 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |