Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
| Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
| Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
| McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
| Xie J et al. | Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. | 1997 | Am. J. Physiol. | pmid:9249487 |
| MartÃnez-Salgado C et al. | Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. | 1997 | Am. J. Physiol. | pmid:9249592 |
| Munoz NM et al. | Effects of PAF on isolated rat airways perfused with blood-free solution. | 1991 | Am. J. Physiol. | pmid:2018147 |
| Olson NC et al. | Role of platelet-activating factor and eicosanoids during endotoxin-induced lung injury in pigs. | 1990 | Am. J. Physiol. | pmid:2163217 |
| Gaboury JP et al. | Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo. | 1994 | Am. J. Physiol. | pmid:7908174 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Sirén AL and Feuerstein G | Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats. | 1989 | Am. J. Physiol. | pmid:2546449 |
| Wallace JL et al. | Platelet-activating factor mediates gastric damage induced by hemorrhagic shock. | 1990 | Am. J. Physiol. | pmid:2372058 |
| Kubes P et al. | Leukocyte-induced vascular protein leakage in cat mesentery. | 1991 | Am. J. Physiol. | pmid:1684268 |
| Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
| Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Gao Y et al. | PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. | 1995 | Am. J. Physiol. | pmid:7653635 |
| Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
| Badr KF et al. | Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. | 1989 | Am. J. Physiol. | pmid:2912165 |
| Beyer AJ et al. | PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis. | 1998 | Am. J. Physiol. | pmid:9724257 |
| Kanwar S et al. | Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. | 1994 | Am. J. Physiol. | pmid:8141295 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
| Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
| Bradley LM et al. | Circulatory effects of PAF-acether in newborn piglets. | 1989 | Am. J. Physiol. | pmid:2912183 |
| Kubes P et al. | Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence. | 1990 | Am. J. Physiol. | pmid:2166441 |
| Wallace JL | Lipid mediators of inflammation in gastric ulcer. | 1990 | Am. J. Physiol. | pmid:2405704 |
| Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Wang GD et al. | Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17030900 |
| Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
| Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| Lautenschläger I et al. | A model of the isolated perfused rat small intestine. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19910525 |
| Lu J et al. | Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356536 |
| Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
| Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| Jiang Y et al. | Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18515648 |