Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Silverstein FS et al. | Cytokines and perinatal brain injury. | 1997 Apr-May | Neurochem. Int. | pmid:9106251 |
Shi C et al. | H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. | 2010 | Neurochem. Int. | pmid:20362023 |
Kondratskaya EL et al. | BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. | 2002 | Neurochem. Int. | pmid:11900860 |
Francescangeli E et al. | Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. | 1997 | Neurochem. Res. | pmid:9342735 |
Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
Yue TL et al. | Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells. | 1992 | Neurochem. Res. | pmid:1324441 |
Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
Calcerrada MC et al. | PAF-stimulated protein tyrosine phosphorylation in hippocampus: involvement of NO synthase. | 2002 | Neurochem. Res. | pmid:11958533 |
Baker RR | Enzymes of platelet activating factor synthesis in brain. | 1995 | Neurochem. Res. | pmid:8786821 |
Lendvai B et al. | Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. | 2001 | Neurochem. Res. | pmid:11699928 |
Sun D et al. | The effect of a free radical scavenger and platelet-activating factor antagonist on FFA accumulation in post-ischemic canine brain. | 1994 | Neurochem. Res. | pmid:8065507 |
Clark GD et al. | Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. | 2000 | Neurochem. Res. | pmid:10905621 |
Wang JH and Sun GY | Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). | 2000 | Neurochem. Res. | pmid:10905622 |
Baker RR | Lipid acetylation reactions and the metabolism of platelet-activating factor. | 2000 | Neurochem. Res. | pmid:10905630 |
Francescangeli E et al. | Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. | 2000 | Neurochem. Res. | pmid:10905633 |
Hirashima Y et al. | Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. | 1997 | Neurochem. Res. | pmid:9342729 |
Wijman CA | Is platelet activity important in acute intracerebral hemorrhage? | 2009 | Neurocrit Care | pmid:19714496 |
Ceriani G et al. | Central neurogenic antiinflammatory action of alpha-MSH: modulation of peripheral inflammation induced by cytokines and other mediators of inflammation. | 1994 | Neuroendocrinology | pmid:8127402 |
Rougeot C et al. | Intracerebroventricular injection of platelet-activating factor induces secretion of adrenocorticotropin, beta-endorphin and corticosterone in conscious rats: a possible link between the immune and nervous systems. | 1990 | Neuroendocrinology | pmid:2157993 |
Altomare A et al. | Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. | 2012 | Neurogastroenterol. Motil. | pmid:22734465 |
Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
Hirashima Y et al. | Analysis of plasma and hematoma lipids related to choline glycerophospholipid in patients with chronic subdural hematoma. | 1994 | Neurol. Med. Chir. (Tokyo) | pmid:7516041 |
Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
Adunsky A et al. | Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke. | 1999 | Neurol. Res. | pmid:10555184 |
Tokutomi T et al. | Production of platelet-activating factor by neuronal cells in the rat brain with cold injury. | 2001 | Neurol. Res. | pmid:11547929 |
Schifitto G et al. | Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. | 1999 | Neurology | pmid:10430432 |
Odawara M et al. | Ginkgo biloba. | 1997 | Neurology | pmid:9065574 |
Clark GD et al. | Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | 1992 | Neuron | pmid:1334422 |
Tarricone C et al. | Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. | 2004 | Neuron | pmid:15572112 |
Bito H et al. | Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. | 1992 | Neuron | pmid:1323312 |
Wieraszko A et al. | Long-term potentiation in the hippocampus induced by platelet-activating factor. | 1993 | Neuron | pmid:8461142 |
Denizot Y et al. | Platelet-activating factor and human meningiomas. | 2006 | Neuropathol. Appl. Neurobiol. | pmid:17083481 |
Gleason MM et al. | Comparison of endothelin binding and calcium mobilization in C6-BU-1 rat glioma and N18TG2 mouse neuroblastoma cells. | 1991 | Neuropeptides | pmid:1654531 |
Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |
Bate C et al. | Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. | 2006 | Neuropharmacology | pmid:16678220 |
Barbanoj MJ et al. | Central and peripheral evaluation of rupatadine, a new antihistamine/platelet-activating factor antagonist, at different doses in healthy volunteers. | 2004 | Neuropsychobiology | pmid:15539863 |
Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
Hostettler ME and Carlson SL | PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury. | 2002 | Neuroreport | pmid:11924887 |
Clark GD et al. | Lipids as axon guidance molecules? | 1995 | Neuroreport | pmid:8741737 |
Clark GD et al. | Platelet-activating factor produces neuronal growth cone collapse. | 1995 | Neuroreport | pmid:8741765 |
Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
Zabøocka B and Domańska-Janik K | PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro. | 1994 | Neuroreport | pmid:7703435 |
Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
Liu WC et al. | Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. | 2007 | Neurosci Bull | pmid:17952135 |
Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
Ezoulin MJ et al. | Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. | 2005 | Neurosci. Lett. | pmid:16095823 |
Lalouette F et al. | Presence of specific platelet-activating factor binding-sites in neuroblastoma N1E-115 cells. | 1995 | Neurosci. Lett. | pmid:7777190 |
Lustig HS et al. | Comparative neurotoxic potential of glutamate, endothelins, and platelet-activating factor in cerebral cortical cultures. | 1992 | Neurosci. Lett. | pmid:1357601 |
Brodie C | Platelet activating factor induces nerve growth factor production by rat astrocytes. | 1995 | Neurosci. Lett. | pmid:7783948 |
Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
Green PG et al. | Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint. | 1993 | Neurosci. Lett. | pmid:8233065 |
Tabuchi S et al. | Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. | 1997 | Neurosci. Lett. | pmid:9406868 |
Liu T et al. | Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia. | 1993 | Neurosci. Lett. | pmid:8152586 |
Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
Reiner B et al. | Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. | 2016 | Neurosci. Lett. | pmid:26808643 |
Jiang ZG et al. | Platelet-activating factor inhibits excitatory transmission in rat neostriatum. | 1993 | Neurosci. Lett. | pmid:8104322 |
Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |
Kolko M et al. | Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. | 2003 | Neurosci. Lett. | pmid:12566178 |
Adachi T et al. | PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells. | 1997 | Neurosci. Lett. | pmid:9406887 |
Catalán RE et al. | Platelet-activating factor inhibits (Na+,K+) ATPase activity in rat brain. | 1994 | Neurosci. Res. | pmid:8008253 |
Green PG et al. | Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters. | 1993 | Neuroscience | pmid:8095706 |
Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
Grassi S and Pettorossi VE | Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2000 | Neuroscience | pmid:11068144 |
Tabarés-Seisdedos R et al. | Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study. | 2006 | Neuroscience | pmid:16549273 |
Green PG et al. | Further substantiation of a significant role for the sympathetic nervous system in inflammation. | 1993 | Neuroscience | pmid:8232896 |
Green PG et al. | Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat. | 1993 | Neuroscience | pmid:8450970 |
Yue TL et al. | Characterization of platelet-activating factor-induced elevation of cytosolic free-calcium level in neurohybrid NCB-20 cells. | 1991 | Neuroscience | pmid:2057061 |
Moriguchi S et al. | Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. | 2010 | Neuroscience | pmid:20074623 |
Jean WC et al. | Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. | 1998 | Neurosurgery | pmid:9848853 |
Koltai M et al. | Platelet-activating factor in septic shock. | 1993 | New Horiz | pmid:7922397 |
Ayala A and Chaudry IH | Platelet activating factor and its role in trauma, shock, and sepsis. | 1996 | New Horiz | pmid:8774801 |
Szabó C | Alterations in nitric oxide production in various forms of circulatory shock. | 1995 | New Horiz | pmid:7535648 |
Christman BW and Bernard GR | Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome. | 1993 | New Horiz | pmid:8087582 |
Fukuoka T | [An experimental study on shock after temporary hepatic inflow occlusion and platelet activating factor (PAF)]. | 1990 | Nihon Geka Gakkai Zasshi | pmid:2263243 |
Fukuoka T et al. | [Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1287460 |
Fukuoka T et al. | [Effect of a platelet activating factor (PAF) antagonist on the hepatic afferent vascular occlusion]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:3412312 |
Onuki Y et al. | [Experimental studies on the relation of platelet activating factor (PAF) to high mortality in sublethal endotoxemia after massive hepatectomy and effects of its antagonist]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:8332121 |
Ono S | [Clinical and experimental studies of septic DIC in surgical patients, in terms of its characteristic features and pathogenesis]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7877583 |
Hirano T and Manabe T | "Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis. | 1992 | Nihon Geka Hokan | pmid:1306981 |
Masugi F et al. | [Kidney medulla and hypertension, with special reference to antihypertensive lipids]. | 1983 | Nihon Jinzo Gakkai Shi | pmid:6663856 |
Komatsu H et al. | Platelet-activating factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells. | 1995 | Nihon Jinzo Gakkai Shi | pmid:8583698 |
Suzuki S et al. | [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. | 1988 | Nihon Jinzo Gakkai Shi | pmid:3244194 |
Inui K | [Participation of platelet activating factor in the pulmonary injury during cardiopulmonary bypass]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8473789 |
Matsumoto K et al. | [Platelet activating factor and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of patients with ARDS]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8315901 |
Shimura S et al. | [Airway hyperresponsiveness and mucus secretion]. | 1990 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1703251 |
Shimizu T | [Platelet-activating factor-from molecular biology to clinic]. | 1994 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7602849 |
Yasugahira H et al. | [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8810754 |
Makino S | [Features and treatment of immediate and late asthmatic responses]. | 1992 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1447838 |
Tsukagoshi H et al. | [Bronchial hyperresponsiveness to histamine in guinea pig induced by intravenous administration of platelet activating factor]. | 1990 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:2290229 |
Tsukagoshi H and Kurosawa M | [Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8391092 |
Ono S et al. | [Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)]. | 1994 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8084100 |
Ono S et al. | [Possible involvement of vascular endothelium-derived relaxing factor induced by platelet-activating factor (PAF) on human pulmonary artery after contraction in vitro]. | 1989 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:2615107 |
Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |