Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bannenberg G et al. | Hydrogen peroxide-induced broncho- and vasoconstriction in the isolated perfused and ventilated guinea pig lung. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372054 |
Chen SF and Ruan YJ | 1 alpha,25-Dihydroxyvitamin D3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema. | 1995 | Pharmacol. Toxicol. | pmid:7479576 |
Moilanen E and Kankaanranta H | Tolfenamic acid and leukotriene synthesis inhibition. | 1994 | Pharmacol. Toxicol. | pmid:7816785 |
Monteiro HS et al. | Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. | 1999 | Pharmacol. Toxicol. | pmid:10522748 |
Ueno M et al. | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. | 1998 | Pharmacology | pmid:9730778 |
Shibamoto T et al. | PAF, rather than histamine, participates in mouse anaphylactic hypotension. | 2008 | Pharmacology | pmid:18583921 |
Kagoshima M et al. | Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs. | 1997 | Pharmacology | pmid:9065955 |
Singh N et al. | Possible mechanism of alprazolam-induced amnesia in mice. | 1998 | Pharmacology | pmid:9467187 |
Merlos M et al. | Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents. | 1990 | Pharmacology | pmid:1697076 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Achterrath-Tuckermann U et al. | Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw edema and bronchoconstriction. | 1988 | Pharmacology | pmid:3380879 |
Suzuki S et al. | Effect of a platelet-activating factor antagonist, WEB 2086, on inhibition of active oxygen generation in human polymorphonuclear leukocytes. | 1994 | Pharmacology | pmid:8134402 |
Capasso F et al. | Effect of senna is not mediated by platelet-activating factor. | 1993 | Pharmacology | pmid:8234442 |
Cheng HH et al. | Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. | 2005 | Pharmacology | pmid:15591819 |
Pei HX et al. | Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. | 2015 | Pharmacology | pmid:26382046 |
Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
Vieweg H et al. | [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-amidines by the reaction with 4-oxo-4H-pyrido(3',2':4,5)-thieno(3,2-d)-1,3-oxazines with secondary cycloaliphatic amines]. | 1992 | Pharmazie | pmid:1492113 |
Kertscher HP and Ostermann G | [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. | 1986 | Pharmazie | pmid:3786385 |
Kertscher HP and Ostermann G | [PAF-antagonists with phospholipid structure. 2. Phospholipids with heteroarene head groups and variations of the phosphorus-nitrogen distance; synthesis, characterization and structure-activity relationships]. | 1991 | Pharmazie | pmid:1803385 |
Kertscher HP and Ostermann G | [PAF-antagonists with phospholipid structure. 3. Phospholipids with heterocyclane head groups and variations of the phosphorus-nitrogen distance; synthesis, characterization and structure-activity relationship]. | 1991 | Pharmazie | pmid:1811226 |
Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
Kertscher HP | [PAF-antagonists with lipid structure. 6. Alkylpropandiol lipids with acyl- and ether- structures at the C-3 position and heterocyclic head groups; synthesis, characterization and structure-activity relationship]. | 1997 | Pharmazie | pmid:9411454 |
Kertscher HP et al. | [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. | 1988 | Pharmazie | pmid:3380866 |
Kertscher HP et al. | [PAF-antagonists with phospholipid structure. 4. Alkylcarbamoylphospholipids with heteroarene and heterocyclase head groups and variation of the P-N-distance; synthesis, characterization and structure-activity relationship]. | 1992 | Pharmazie | pmid:1615020 |
Kertscher HP et al. | [PAF-antagonists with a phospholipid structure. 1. Phospholipids with hetero-arene head groups: synthesis, characterization and determination of the action of structural elements]. | 1991 | Pharmazie | pmid:1798710 |
Asai Y | Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. | 2005 | Pharmazie | pmid:15801673 |
Kertscher HP et al. | [PAF-antagonists with a phospholipid structure. 5. Propanediol phospholipids with various substituted pyridinium and quinuclidinium head groups and variations of the phosphorus-nitrogen distance;synthesis, characterization and structure activity relationship]. | 1993 | Pharmazie | pmid:8460172 |
Ostermann G et al. | [Platelet activating factor--a biologically active phospholipid]. | 1990 | Pharmazie | pmid:2236190 |
Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
Wagner G et al. | [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-formamidines corresponding alkyl esters with antianaphylactic activity]. | 1993 | Pharmazie | pmid:8493283 |
Remacle J et al. | [Behavior of human endothelial cells in hyperoxia and hypoxia: effect of Ginkor Fort]. | 1990 Apr-Jun | Phlebologie | pmid:2236246 |
Sahu RP et al. | Platelet-activating factor does not mediate UVB-induced local immune suppression. | 2012 Mar-Apr | Photochem. Photobiol. | pmid:22211638 |
Bihl JC et al. | UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. | 2016 | Photochem. Photobiol. | pmid:26876152 |
Gorman S and Hart PH | The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation. | 2012 | Photochem. Photobiol. Sci. | pmid:22898802 |
Kispert SE et al. | Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. | 2017 | Physiol Rep | pmid:28270596 |
Petho G and Reeh PW | Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. | 2012 | Physiol. Rev. | pmid:23073630 |
Montrucchio G et al. | Role of platelet-activating factor in cardiovascular pathophysiology. | 2000 | Physiol. Rev. | pmid:11015622 |
Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
Chang FR et al. | Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea. | 1998 | Phytochemistry | pmid:9883592 |
Bai J et al. | Sesquiterpenes from the roots of Illicium dunnianum. | 2012 | Phytochemistry | pmid:22695122 |
Tsai IL et al. | Anti-platelet aggregation constituents from Formosan Toddalia asiatica. | 1998 | Phytochemistry | pmid:9720317 |
Coy-Barrera ED et al. | PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). | 2009 | Phytochemistry | pmid:19674762 |
Calligerou M et al. | Platelet activating factor and lyso-phosphatidylcholines from strawberry. | 1996 | Phytochemistry | pmid:8588879 |
Koch E | Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. | 2005 | Phytomedicine | pmid:15693702 |
Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
Amroyan E et al. | Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. | 1999 | Phytomedicine | pmid:10228608 |
Shehnaz D et al. | Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets. | 1999 | Phytother Res | pmid:10441792 |
Chu W et al. | Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. | 2008 | Phytother Res | pmid:17724771 |
Jantan I et al. | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. | 2004 | Phytother Res | pmid:15742349 |
Oku H and Ishiguro K | Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. | 1999 | Phytother Res | pmid:10479766 |
Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
Melnikova VO and Bar-Eli M | Inflammation and melanoma metastasis. | 2009 | Pigment Cell Melanoma Res | pmid:19368690 |
Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
Serra MF et al. | Anti-allergic properties of the natural PAF antagonist yangambin. | 1997 | Planta Med. | pmid:9225600 |
Ekimoto H et al. | Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide. | 1991 | Planta Med. | pmid:2062958 |
Steinke B et al. | [Biological standardization of Ginkgo extracts]. | 1993 | Planta Med. | pmid:8488195 |
Burgos RA et al. | 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. | 2005 | Planta Med. | pmid:16041644 |
Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
Oku H et al. | Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. | 2005 | Planta Med. | pmid:15678383 |
Yang HO et al. | Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. | 1995 | Planta Med. | pmid:8824945 |
Li CL and Wong YY | The bioavailability of ginkgolides in Ginkgo biloba extracts. | 1997 | Planta Med. | pmid:9434615 |
Yang HO et al. | Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis. | 1995 | Planta Med. | pmid:7700989 |
Castro-Faria-Neto HC et al. | Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: binding and in vitro functional studies. | 1995 | Planta Med. | pmid:7753913 |
Ysrael MC and Croft KD | Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. | 1990 | Planta Med. | pmid:2168055 |
Liao HJ et al. | Two new ginkgolides from the leaves of Ginkgo biloba. | 2011 | Planta Med. | pmid:21614751 |
Saeed SA et al. | Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. | 1993 | Planta Med. | pmid:8302958 |
Sheen WS et al. | Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. | 1996 | Planta Med. | pmid:8657756 |
Tuominen M et al. | Effects of Calaguala and an active principle, adenosine, on platelet activating factor. | 1992 | Planta Med. | pmid:1438589 |
Jantan I et al. | Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | 2001 | Planta Med. | pmid:11488464 |
Kim KA et al. | Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. | 1999 | Planta Med. | pmid:10083843 |
Ishiguro K et al. | Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension. | 2002 | Planta Med. | pmid:11914965 |
Yang HO and Han BH | Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis. | 1998 | Planta Med. | pmid:9491770 |
Stotland MA and Kerrigan CL | The role of platelet-activating factor in musculocutaneous flap reperfusion injury. | 1997 | Plast. Reconstr. Surg. | pmid:9180723 |
Chan MV et al. | Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. | 2011 | Platelets | pmid:21806492 |
Eriksson AC and Whiss PA | Nanomolar concentrations of adrenaline induce platelet adhesion in vitro. | 2013 | Platelets | pmid:22471400 |
Storey RF et al. | Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. | 2001 | Platelets | pmid:11674863 |
Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
Baskova I et al. | Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. | 2000 | Platelets | pmid:10938885 |
Kennedy MA et al. | Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. | 2011 | PLoS Genet. | pmid:21347278 |
Jeewandara C et al. | Platelet activating factor contributes to vascular leak in acute dengue infection. | 2015 | PLoS Negl Trop Dis | pmid:25646838 |
Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
Gale TV et al. | Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. | 2017 | PLoS Negl Trop Dis | pmid:28922385 |
Shida-Sakazume T et al. | Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. | 2015 | PLoS ONE | pmid:25803864 |
Lautenschläger I et al. | Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. | 2015 | PLoS ONE | pmid:25793535 |
Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
Smit JJ et al. | Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. | 2011 | PLoS ONE | pmid:22194949 |
Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
Fragel-Madeira L et al. | Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. | 2011 | PLoS ONE | pmid:21298035 |
de Souza Carmo EV et al. | Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages. | 2010 | PLoS ONE | pmid:21082032 |
Mirpuri J et al. | Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. | 2012 | PLoS ONE | pmid:23272193 |
Forsman H et al. | Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. | 2013 | PLoS ONE | pmid:23555913 |
Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
Zhao C et al. | Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. | 2013 | PLoS ONE | pmid:24367540 |
Jeong YI et al. | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. | 2009 | PLoS ONE | pmid:19652714 |
Hasegawa S et al. | Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. | 2010 | PLoS ONE | pmid:20454616 |
Täubel J et al. | Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. | 2016 | PLoS ONE | pmid:27632557 |
Jacob SP et al. | Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance. | 2016 | PLoS ONE | pmid:27064683 |