Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Noguchi K et al. | The detection of platelet-activating factor in inflamed human gingival tissue. | 1989 | Arch. Oral Biol. | pmid:2783040 |
Hirafuji M and Shinoda H | Increased prostaglandin I2 and thromboxane A2 production by rat dental pulp after intravenous administration of endotoxin. | 1994 | Arch. Oral Biol. | pmid:7695514 |
Krause S et al. | Aggregation behaviour of blood granulocytes in patients with periodontal disease. | 1990 | Arch. Oral Biol. | pmid:2390026 |
Nohutcu RM et al. | Effects of hormones and cytokines on stimulation of adenylate cyclase and intracellular calcium concentration in human and canine periodontal-ligament fibroblasts. | 1993 | Arch. Oral Biol. | pmid:7506523 |
Rosenbaum JT et al. | Synthesis of platelet activating factor by ocular tissue from inflamed eyes. | 1991 | Arch. Ophthalmol. | pmid:2003804 |
Rubin RM et al. | Prostaglandin-independent inhibition of ocular vascular permeability by a platelet-activating factor antagonist. | 1988 | Arch. Ophthalmol. | pmid:3261165 |
Hruby ZW et al. | Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. | 1991 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:1668710 |
Wysocki H | The role of polymorphonuclear neutrophils in myocardial damage during ischemia and reperfusion. | 1992 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:1485826 |
Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
Dubovsky SL et al. | Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. | 1989 | Arch. Gen. Psychiatry | pmid:2735813 |
de Boissieu D et al. | [Study of platelet-activating factor (PAF) in stools of newborn infants with hemorrhagic colitis]. | 1991 Aug-Sep | Arch. Fr. Pediatr. | pmid:1929756 |
Morville P and Heymann M | [Regulation of perinatal pulmonary circulation]. | 1989 Jun-Jul | Arch. Fr. Pediatr. | pmid:2783008 |
Travers J et al. | Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783. | 1998 | Arch. Dermatol. Res. | pmid:9836508 |
Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
Kemény L et al. | Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice. | 1996 | Arch. Dermatol. Res. | pmid:8844132 |
Lazanas M et al. | PAF of biological fluids in disease: IV. Levels in blood in allergic reactions induced by drugs. | 1988 | Arch. Dermatol. Res. | pmid:3395143 |
Kemény L et al. | Pharmacological studies on dithranol-induced irritative dermatitis in mice. | 1989 | Arch. Dermatol. Res. | pmid:2529819 |
Judge MR et al. | Platelet activating factor (PAF) and lyso-PAF in psoriasis. | 1994 | Arch. Dermatol. Res. | pmid:7818279 |
Jørgensen KM et al. | Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2. | 2010 | Arch. Dermatol. Res. | pmid:20041255 |
Alappatt C et al. | Acute keratinocyte damage stimulates platelet-activating factor production. | 2000 | Arch. Dermatol. Res. | pmid:10867814 |
RodrÃguez Roisin R | [Platelet activating factor and bronchial asthma. Is it relevant?]. | 1997 | Arch. Bronconeumol. | pmid:9280556 |
Ohtsuka T et al. | Synergism between platelet-activating factor and diacylglycerol in the induction of superoxide anion production in guinea pig polymorphonuclear leukocytes. | 1990 | Arch. Biochem. Biophys. | pmid:2159756 |
Shukla SD and Hanahan DJ | An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor). | 1983 | Arch. Biochem. Biophys. | pmid:6320731 |
Lee T et al. | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. | 2001 | Arch. Biochem. Biophys. | pmid:11368182 |
Furukawa M et al. | Metabolic fate of platelet-activating factor in the rat enterocyte: the role of a specific lysophospholipase D. | 1995 | Arch. Biochem. Biophys. | pmid:7771795 |
Lekka M et al. | Isolation of a phospholipid inhibitor of platelet activating factor-induced activity from perfused rat liver: identification as phosphatidylglycerol. | 1993 | Arch. Biochem. Biophys. | pmid:8489242 |
Shukla SD | Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. | 1985 | Arch. Biochem. Biophys. | pmid:3875314 |
Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
Chao W et al. | Regulation of platelet-activating factor receptor and PAF receptor-mediated arachidonic acid release by protein kinase C activation in rat Kupffer cells. | 1990 | Arch. Biochem. Biophys. | pmid:2171429 |
Kimoto M et al. | Dual effects of oleic acid on Ca2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1384432 |
Kajiyama Y et al. | Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2505676 |
Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
Zhou W and Olson MS | A mechanism for phorbol ester-mediated regulation of the PAF receptor in human neutrophils. | 1994 | Arch. Biochem. Biophys. | pmid:8053680 |
Satouchi K et al. | Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. | 1981 | Arch. Biochem. Biophys. | pmid:7305392 |
Zhou W et al. | Impaired surface expression of PAF receptors on human neutrophils is dependent upon cell activation. | 1994 | Arch. Biochem. Biophys. | pmid:8109973 |
Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
Svetlov SI et al. | Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. | 1996 | Arch. Biochem. Biophys. | pmid:8615681 |
Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Enhancement of chlorophyll a fluorescence yield, low-temperature F685/F730 fluorescence emission ratio, and electron transport rate by ether phospholipids (platelet activating factor and analogs) in isolated chloroplasts. | 1989 | Arch. Biochem. Biophys. | pmid:2817899 |
Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
Ban C et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. | 1986 | Arch. Biochem. Biophys. | pmid:3963833 |
Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. | 1985 | Arch. Biochem. Biophys. | pmid:4037794 |
Eguchi H et al. | Binding and metabolism of platelet-activating factor (PAF) by isolated rat type II pneumonocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8109971 |
Vallari DS et al. | Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator. | 1990 | Arch. Biochem. Biophys. | pmid:2154953 |
Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
Nunez D et al. | Inhibition of [3H]platelet activating factor (PAF) binding by Zn2+: a possible explanation for its specific PAF antiaggregating effects in human platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2502069 |
Lee TC et al. | Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway. | 1983 | Arch. Biochem. Biophys. | pmid:6407399 |
Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
Toyoshima K et al. | Coenzyme A-independent transacylation in amnion-derived (WISH) cells. | 1994 | Arch. Biochem. Biophys. | pmid:7944398 |
Ihara Y et al. | Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. | 1993 | Arch. Biochem. Biophys. | pmid:8346925 |
Sanwick JM et al. | Human spermatozoa produce C16-platelet-activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1575513 |
Hwang SB | Specific receptor sites for platelet activating factor on rat liver plasma membranes. | 1987 | Arch. Biochem. Biophys. | pmid:2821908 |
Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
Pieroni G and Hanahan DJ | Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets. | 1983 | Arch. Biochem. Biophys. | pmid:6870274 |
Sugiura T et al. | Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor. | 1994 | Arch. Biochem. Biophys. | pmid:8203898 |
Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
Jones RE | Synthesis of ether lipids and phosphatidylethanolamine by ejaculated human spermatozoa. | 1997 May-Jun | Arch. Androl. | pmid:9140614 |
Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
Kelly GL and Eiseman B | Development of a new vascular prosthetic: lessons learned. | 1982 | Arch Surg | pmid:7125901 |
Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
Emil S et al. | Inhaled nitric oxide prevents experimental platelet activating factor-induced shock. | 1996 | Arch Surg | pmid:8712910 |
Biffl WL et al. | Interleukin-6 potentiates neutrophil priming with platelet-activating factor. | 1994 | Arch Surg | pmid:7979944 |
Lo CJ et al. | Endotoxin-induced macrophage gene expression depends on platelet-activating factor. | 1997 | Arch Surg | pmid:9403541 |
Fletcher JR | Eicosanoids. Critical agents in the physiological process and cellular injury. | 1993 | Arch Surg | pmid:8239981 |
Thompson WA et al. | The metabolic effects of platelet-activating factor antagonism in endotoxemic man. | 1994 | Arch Surg | pmid:8279943 |
Hemmendinger S et al. | [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. | 1985 | Arch Mal Coeur Vaiss | pmid:3938941 |
Jambou D et al. | [Mediators of the vascular endothelium as markers of myocardial ischemia and reperfusion]. | 1993 | Arch Mal Coeur Vaiss | pmid:8304814 |
Gateau O | [Role of PAF-acether (platelet activating factor) in cardio-vascular pathology]. | 1987 | Arch Mal Coeur Vaiss | pmid:3117010 |
Subissi A et al. | Octylonium bromide, an antagonist of platelet-activating factor. | 1989 Nov-Dec | Arch Int Pharmacodyn Ther | pmid:2636821 |
Yamada T et al. | Pharmacological properties of YM264, a potent and orally active antagonist of platelet-activating factor. | 1990 Nov-Dec | Arch Int Pharmacodyn Ther | pmid:2099131 |
Damas J et al. | Inhibition by WEB 2086, a PAG-acether antagonist of oedema and peritonitis induced by zymosan in rats. | 1990 Jul-Aug | Arch Int Pharmacodyn Ther | pmid:2076045 |
Damas J and Prunescu P | Presence of immunoreactive platelet-activating factor in peritoneal exudate induced by zymosan in rats. | 1993 Mar-Apr | Arch Int Pharmacodyn Ther | pmid:8215712 |
Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
Torley LW et al. | Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. | 1992 | Antimicrob. Agents Chemother. | pmid:1416889 |
Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
Zimmermann A and Keller H | Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). | 1993 Mar-Apr | Anticancer Res. | pmid:8390801 |
Adamson LM et al. | Release of anti-PAF activity from PAF-binding human ovarian cancer cells in culture. | 1992 Mar-Apr | Anticancer Res. | pmid:1580546 |
Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
Bach MK | Mediators of anaphylaxis and inflammation. | 1982 | Annu. Rev. Microbiol. | pmid:6128957 |
Larsen GL and Henson PM | Mediators of inflammation. | 1983 | Annu. Rev. Immunol. | pmid:6399978 |
Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
Zehr KJ et al. | Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7847945 |
Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |