Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iwamoto I et al. | Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice. | 1992 | J. Leukoc. Biol. | pmid:1358993 |
| Moritoki H et al. | Involvement of nitric oxide pathway in the PAF-induced relaxation of rat thoracic aorta. | 1992 | Br. J. Pharmacol. | pmid:1358382 |
| Juhlin L and Pihl-Lundin I | Effects of antihistamines on cutaneous reactions and influx of eosinophils after local injection of PAF, kallikrein, compound 48/80 and histamine in patients with chronic urticaria and healthy subjects. | 1992 | Acta Derm. Venereol. | pmid:1357858 |
| Lustig HS et al. | Comparative neurotoxic potential of glutamate, endothelins, and platelet-activating factor in cerebral cortical cultures. | 1992 | Neurosci. Lett. | pmid:1357601 |
| Narita S et al. | [Effects of anti-PAF agents on nasal response after allergen challenge in guinea pigs]. | 1992 | Nippon Jibiinkoka Gakkai Kaiho | pmid:1357119 |
| Chihara J et al. | Possible induction of intercellular adhesion molecule-1 (ICAM-1) expression on endothelial cells by platelet-activating factor (PAF). | 1992 Jun-Jul | J Lipid Mediat | pmid:1356028 |
| Page C | Asthma as a chronic inflammatory disease and the implications for future therapy. | 1992 | Ann Allergy | pmid:1355953 |
| Castro-Faria-Neto HC et al. | Interference of azelastine with anaphylaxis induced by ovalbumin challenge in actively sensitized rats. | 1992 | Eur. J. Pharmacol. | pmid:1355732 |
| Orallo F et al. | Effects of platelet activating factor on contractions and 45Ca influx induced by noradrenaline and potassium in rat rubbed and intact aorta. Comparison with its hypotensive effect in anaesthetized normotensive rats. | 1992 | J. Pharm. Pharmacol. | pmid:1355548 |
| Kirsch CM et al. | Mechanism of platelet activating factor-induced vascular leakage in the rat trachea. | 1992 Jul-Aug | Exp. Lung Res. | pmid:1355425 |
| Bienvenu K et al. | Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules. | 1992 | Circ. Res. | pmid:1355410 |
| Pinto A et al. | Time course of PAF formation by gastrointestinal tissue in rats after castor oil challenge. | 1992 | J. Pharm. Pharmacol. | pmid:1354728 |
| Le Gouvello S et al. | CD2 triggering stimulates the formation of platelet-activating factor-acether from alkyl-arachidonoyl-glycerophosphocholine in a human CD4+ T lymphocyte clone. | 1992 | J. Immunol. | pmid:1354232 |
| Bodis J and Tinneberg HR | Migraine. | 1992 | Lancet | pmid:1351648 |
| Calabresse C et al. | Induction of high-affinity paf receptor expression during T cell activation. | 1992 | Eur. J. Immunol. | pmid:1350980 |
| Kamei C et al. | Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. | 1992 | Immunopharmacol Immunotoxicol | pmid:1350791 |
| Martins MA et al. | Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. | 1992 | Br. J. Pharmacol. | pmid:1350745 |
| Thorne KJ et al. | Increased binding of urease by activated eosinophils. Reassessment of an ELISA for CD11b. | 1992 | J. Immunol. Methods | pmid:1349905 |
| Richards B | From proteins to protein interacting drugs. | 1992 | J. Pharm. Pharmacol. | pmid:1348279 |
| Benigni A et al. | Urinary excretion of platelet-activating factor in haemolytic uraemic syndrome. | 1992 | Lancet | pmid:1347859 |
| Chaussade S et al. | Paf-acether in stool as marker of intestinal inflammation. | 1992 | Lancet | pmid:1347599 |
| Sugiyama H et al. | The effect of a selective alpha 2-adrenergic receptor antagonist (midaglizole) on the cyclic 3',5'-adenosine monophosphate production in human mononuclear cells. | 1992 | J. Allergy Clin. Immunol. | pmid:1347546 |
| Yan ZY et al. | Platelet activating factor-induced changes in gastric motility and vascular resistance. | 1992 | Am. J. Surg. | pmid:1346361 |
| Kempe ER and Blank B | Triazolam and PAF inhibition. | 1992 | Lancet | pmid:1345974 |
| Jonas JM | Triazolam and PAF inhibition. | 1992 | Lancet | pmid:1345973 |
| Chuang TT et al. | High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. | 1992 | J. Biol. Chem. | pmid:1339451 |
| Walker BA and Ward PA | Priming and signal transduction in neutrophils. | 1992 Sep-Oct | Biol. Signals | pmid:1339178 |
| Doucet JP and Bazan NG | Excitable membranes, lipid messengers, and immediate-early genes. Alteration of signal transduction in neuromodulation and neurotrauma. | 1992 | Mol. Neurobiol. | pmid:1337456 |
| Watanabe T | [Metabolism and action mechanisms of eicosanoids and platelet-activating factor in the kidney]. | 1992 | Nippon Rinsho | pmid:1337118 |
| Smith IL and Smith EA | Inhibition of PAF-induced activation of human platelets by verapamil. | 1992 | Blood Coagul. Fibrinolysis | pmid:1336985 |
| Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
| Hayes JP et al. | Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium. | 1992 | Eur. Respir. J. | pmid:1336735 |
| Wissner A et al. | Analogues of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF. | 1992 | J. Med. Chem. | pmid:1336052 |
| Ahmed AS and Smith SK | The endometrium: prostaglandins and intracellular signalling at implantation. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1335852 |
| Camussi G et al. | Porins and lipopolysaccharide stimulate platelet activating factor synthesis by human mesangial cells. | 1992 | Kidney Int. | pmid:1335527 |
| Müller S and Nigam S | Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1335246 |
| Hii CS et al. | Basal and phorbol-ester-stimulated turnover of phosphatidylcholine in HeLa cells involve different pathways. | 1992 | Biochem. J. | pmid:1335237 |
| Chao W et al. | Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. | 1992 | Biochem. J. | pmid:1335232 |
| Sargeant P et al. | Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry. | 1992 | Cell Calcium | pmid:1334809 |
| Tanimoto Y et al. | Effects of cytokines on human basophil chemotaxis. | 1992 | Clin. Exp. Allergy | pmid:1334781 |
| Tashiro K et al. | Effects of PAF on excitatory neuro-effector transmission in dog airways. | 1992 | Br. J. Pharmacol. | pmid:1334755 |
| Kadiri C et al. | Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF. | 1992 | Br. J. Pharmacol. | pmid:1334747 |
| Burgers JA and Akkerman JW | Effect of platelet agonists on the binding of platelet-activating factor to human platelets. | 1992 | J Lipid Mediat | pmid:1334723 |
| Kudolo GB and Harper MJ | Pregnancy-associated remodeling of rabbit endometrial platelet-activating factor receptors. | 1992 | J Lipid Mediat | pmid:1334722 |
| Qian C et al. | Increased platelet-activating factor (PAF) concentrations in hearts and lungs of Pichinde virus-infected guinea pigs. | 1992 | J Lipid Mediat | pmid:1334721 |
| Bochkov VN et al. | Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins. | 1992 | Atherosclerosis | pmid:1334652 |
| Menegazzi R et al. | A new, one-step assay on whole cell suspensions for peroxidase secretion by human neutrophils and eosinophils. | 1992 | J. Leukoc. Biol. | pmid:1334501 |
| Clark GD et al. | Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | 1992 | Neuron | pmid:1334422 |
| Schrör K and Felsch A | Ramiprilat prevents PAF-induced myocellular and endothelial injury in a neutrophil-perfused heart preparation. | 1992 | Agents Actions Suppl. | pmid:1334351 |
| Bauldry SA et al. | Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production. | 1992 | J. Biol. Chem. | pmid:1334083 |
| Bautista AP and Spitzer JJ | Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. | 1992 | Free Radic. Res. Commun. | pmid:1334036 |
| Nakamura M et al. | Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. | 1992 | FEBS Lett. | pmid:1333988 |
| Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
| Selak MA | Neutrophil elastase potentiates cathepsin G-induced platelet activation. | 1992 | Thromb. Haemost. | pmid:1333649 |
| Cattaneo M et al. | Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. | 1992 | Blood | pmid:1333302 |
| Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
| O'Flaherty JT et al. | Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. | 1992 | Biochem. J. | pmid:1332696 |
| Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
| Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
| Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
| Valone FH | Binding of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine to intact platelets and platelet membranes. | 1992 | Meth. Enzymol. | pmid:1331707 |
| Atochina EN et al. | Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme. | 1992 | Lung | pmid:1331624 |
| Thivierge M and Rola-Pleszczynski M | Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. | 1992 | J. Allergy Clin. Immunol. | pmid:1331218 |
| Kester M et al. | Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells. | 1992 | J. Cell. Physiol. | pmid:1331121 |
| el-Moatassim C and Dubyak GR | A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages. | 1992 | J. Biol. Chem. | pmid:1331096 |
| Müller S and Nigam S | Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide. | 1992 | Eur. J. Pharmacol. | pmid:1330596 |
| Nagahisa A et al. | Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist. | 1992 | Eur. J. Pharmacol. | pmid:1330589 |
| Hiraide A et al. | Platelet-activating factor causes hypoketonaemia in starved rats. | 1992 | Clin. Sci. | pmid:1330413 |
| Grigoriadis G and Stewart AG | Albumin inhibits platelet-activating factor (PAF)-induced responses in platelets and macrophages: implications for the biologically active form of PAF. | 1992 | Br. J. Pharmacol. | pmid:1330167 |
| Rossi AG et al. | The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. | 1992 | Br. J. Pharmacol. | pmid:1330163 |
| Shimizu T et al. | Platelet-activating factor receptor and signal transduction. | 1992 | Biochem. Pharmacol. | pmid:1329754 |
| Shukla SD et al. | Hypersensitivity of diabetic human platelets to platelet activating factor. | 1992 | Thromb. Res. | pmid:1329254 |
| Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
| Domingo MT et al. | Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists. | 1992 | Lipids | pmid:1328798 |
| Bensard DD et al. | Platelet activating factor alters receptor-coupled function in the isolated perfused rat heart. | 1992 | J. Surg. Res. | pmid:1328766 |
| Brady HR et al. | Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury. | 1992 | Kidney Int. | pmid:1328754 |
| Nguer CM et al. | Regulation of paf-acether receptor expression in human B cells. | 1992 | J. Immunol. | pmid:1328384 |
| Alvaro RF et al. | Determination of enantiomeric concentrations of a 2,5-diaryltetrahydrofuran (L-668,750), a platelet-activating factor receptor antagonist, in rat plasma using a chiral alpha 1-acid glycoprotein high-performance liquid chromatographic column. | 1992 | J. Chromatogr. | pmid:1328270 |
| Liu H et al. | Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. | 1992 | J. Biol. Chem. | pmid:1328211 |
| Ko FN et al. | PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. | 1992 | Eur. J. Pharmacol. | pmid:1327822 |
| Chung KF | Platelet-activating factor in inflammation and pulmonary disorders. | 1992 | Clin. Sci. | pmid:1327626 |
| Schmidt J et al. | Characterization of platelet-activating factor induced superoxide anion generation by guinea-pig alveolar macrophages. | 1992 | J Lipid Mediat | pmid:1327265 |
| Herbert JM et al. | Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding. | 1992 | J Lipid Mediat | pmid:1327264 |
| Kuznetsova TI and Kulikov VI | [The effect of aldehydogenic and acyl structural analogs of platelet activating factor on the formation of superoxide radicals by human blood leukocytes]. | 1992 | Biokhimiia | pmid:1327185 |
| Nieminen MM et al. | Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man. | 1992 | Br J Clin Pharmacol | pmid:1327049 |
| Jamil KM et al. | Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). | 1992 | Biochem. Biophys. Res. Commun. | pmid:1326956 |
| Turner NC and Wood LJ | Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1326625 |
| Ikegami K et al. | Hetrazepine PAF antagonists. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326346 |
| Sugiura T et al. | Synthesis and action of PAF in human eosinophils. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326345 |
| Honda Z et al. | Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326344 |
| Agrawal DK et al. | PAF receptors and G-proteins in human blood eosinophils and neutrophils. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326343 |
| Sung CP et al. | CGRP stimulates the adhesion of leukocytes to vascular endothelial cells. | 1992 May-Jun | Peptides | pmid:1326102 |
| Mazer BD et al. | Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. | 1992 | J. Clin. Invest. | pmid:1325997 |
| Travers JB et al. | Binding of carbamyl-platelet-activating factor to the Raji lymphoblast platelet-activating factor receptor. | 1992 | Int. J. Immunopharmacol. | pmid:1325953 |
| Hiltz ME et al. | Alpha-MSH peptides inhibit acute inflammation induced in mice by rIL-1 beta, rIL-6, rTNF-alpha and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8. | 1992 | Cytokine | pmid:1325196 |
| Salari H et al. | Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells. | 1992 | Biochem. Cell Biol. | pmid:1324692 |
| Wang S and Townley RG | Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. | 1992 | Ann Allergy | pmid:1324627 |
| Yue TL et al. | Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells. | 1992 | Neurochem. Res. | pmid:1324441 |
| Rabinovici R et al. | Role of complement in endotoxin/platelet-activating factor-induced lung injury. | 1992 | J. Immunol. | pmid:1324280 |
| Brodie C et al. | Ethanol inhibits ligand-activated Ca2+ channels in human B lymphocytes. | 1992 | J. Cell. Physiol. | pmid:1324242 |