Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lugrin D et al. | [Thrombocytopenia induced by heparin and cardiac surgery with extracorporeal circulation]. | 1990 | Ann Fr Anesth Reanim | pmid:2400150 |
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Wang S and Townley RG | Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. | 1992 | Ann Allergy | pmid:1324627 |
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Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |
Gupta JB et al. | Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | 1994 | Angiology | pmid:8285381 |
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Pierce PA et al. | Halothane selectively inhibits bradykinin-induced synovial plasma extravasation. | 1995 | Anesthesiology | pmid:7661358 |
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Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
Hofer RE et al. | The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. | 1993 | Anesthesiology | pmid:8342844 |
Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
Geiser T | The role of neutrophils and neutrophil products in pulmonary hemodynamics of endotoxin in oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742354 |
Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
Nathan N et al. | Effects of the platelet-activating factor receptor antagonist BN 52021 on hematologic variables and blood loss during and after cardiopulmonary bypass. | 1994 | Anesth. Analg. | pmid:7639352 |
Ereth MH et al. | Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass? | 1997 | Anesth. Analg. | pmid:9249097 |
Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
Goldsmith JA et al. | Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung. | 1996 | Anesth. Analg. | pmid:8694300 |
Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
Hu G et al. | Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels. | 2002 | Anesth. Analg. | pmid:11916783 |
Habazettl H et al. | Pulmonary hypertension after heparin-protamine: roles of left-sided infusion, histamine, and platelet-activating factor. | 1990 | Anesth. Analg. | pmid:2240637 |
Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
Lebedeva RN et al. | [The status of the receptor-controlled calcium metabolism of the thrombocytes in patients in the early postoperative period]. | 1991 Sep-Oct | Anesteziol Reanimatol | pmid:1767948 |
Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |
Ohyama T et al. | Sensitive densitometry for the determination of platelet-activating factor and other phospholipids in human tears. | 1996 | Analyst | pmid:9008409 |
Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
Nikolelis DP and Siontorou CG | Ammonium ion minisensors form self-assembled bilayer lipid membranes using gramicidin as an ionophore. Modulation of ammonium selectivity by platelet-activating factor. | 1996 | Anal. Chem. | pmid:8651482 |
Weintraub ST et al. | Synthesis of pentafluorobenzoic anhydride: a superior derivatizing agent for lipids. | 1993 | Anal. Chem. | pmid:8238933 |
Callender HL et al. | Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. | 2007 | Anal. Chem. | pmid:17194150 |
Balazy M et al. | Determination of platelet-activating factor and alkyl-ether phospholipids by gas chromatography-mass spectrometry via direct derivatization. | 1991 | Anal. Biochem. | pmid:1888023 |
Ekholm J et al. | The human platelet as a reproducible and sensitive cell for the detection and assay of platelet-activating factor. | 1992 | Anal. Biochem. | pmid:1514698 |
Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
Hendrickson HS et al. | Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. | 1999 | Anal. Biochem. | pmid:10585741 |
Rao GH | Measurement of ionized calcium in normal human blood platelets. | 1988 | Anal. Biochem. | pmid:3382012 |
Mita H et al. | Quantitation of platelet-activating factor by high-performance liquid chromatography with fluorescent detection. | 1989 | Anal. Biochem. | pmid:2817335 |
Boyle T et al. | Method for simultaneous isolation and quantitation of platelet activating factor and multiple arachidonate metabolites from small samples: analysis of effects of Staphylococcus aureus enterotoxin B in mice. | 1994 | Anal. Biochem. | pmid:8179192 |
Oda Y et al. | Quantitation of platelet-activating factor in biological samples using liquid chromatography/mass spectrometry with column-switching technique. | 1995 | Anal. Biochem. | pmid:8678293 |
Bossant MJ et al. | Quantitation of paf-acether by release of endogenous platelet serotonin assessed by liquid chromatography with electrochemical detection. | 1989 | Anal. Biochem. | pmid:2610359 |
Sanz-Vicente I et al. | Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | 2017 | Anal. Biochem. | pmid:27956151 |
Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
Adam K and Oswald I | [Triazolam is different: it is a PAF antagonist]. | 1992 | Anaesthesist | pmid:1562092 |
Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
Boschetto P et al. | Corticosteroid inhibition of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2001074 |
Stengel PW et al. | Inhaled A23187 produces a preferential sensitization to substance P. | 1993 | Am. Rev. Respir. Dis. | pmid:7678372 |
Daniel EE and O'Byrne P | Effect of inflammatory mediators on airway nerves and muscle. | 1991 | Am. Rev. Respir. Dis. | pmid:2003686 |
Meade CJ and Heuer H | PAF antagonism as an approach to the treatment of airway hyperreactivity. | 1991 | Am. Rev. Respir. Dis. | pmid:2003696 |
Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
Smith LJ | The role of platelet-activating factor in asthma. | 1991 | Am. Rev. Respir. Dis. | pmid:2018248 |
Henderson WR | Eicosanoids and platelet-activating factor in allergic respiratory diseases. | 1991 | Am. Rev. Respir. Dis. | pmid:1902069 |
Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
Ohar JA et al. | A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2297169 |
Lohman I and Halonen M | Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. | 1990 | Am. Rev. Respir. Dis. | pmid:2382903 |
Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
Lien DC et al. | Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1546852 |
Oda M et al. | The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. | 1990 | Am. Rev. Respir. Dis. | pmid:2350088 |
Nakajima H et al. | CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1362635 |
Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
Pretolani M et al. | Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. | 1990 | Am. Rev. Respir. Dis. | pmid:2160213 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
Horvath CJ et al. | Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. | 1991 | Am. Rev. Respir. Dis. | pmid:1741548 |
Lantz RC et al. | The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin. | 1991 | Am. Rev. Respir. Dis. | pmid:2064124 |
Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
Murphy RC and Clay KL | Measurement of platelet-activating factor by physicochemical technique s. | 1987 | Am. Rev. Respir. Dis. | pmid:3300445 |
Page CP | Mechanisms of hyperresponsiveness: platelet-activating factor. | 1992 | Am. Rev. Respir. Dis. | pmid:1734810 |
Halonen M et al. | Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. | 1980 | Am. Rev. Respir. Dis. | pmid:7458063 |
Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
Tokuyama K et al. | Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. | 1991 | Am. Rev. Respir. Dis. | pmid:2048823 |
Lansing MW et al. | Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. | 1991 | Am. Rev. Respir. Dis. | pmid:1741541 |
Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
Watson JW et al. | IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. | 1990 | Am. Rev. Respir. Dis. | pmid:2240832 |
Tocker JE et al. | Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. | 1990 | Am. Rev. Respir. Dis. | pmid:2240843 |
Kidney JC et al. | Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. | 1993 | Am. Rev. Respir. Dis. | pmid:8420421 |
Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
Kuitert LM et al. | Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. | 1993 | Am. Rev. Respir. Dis. | pmid:8420437 |
Wardlaw AJ et al. | Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. | 1990 | Am. Rev. Respir. Dis. | pmid:2405759 |
Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
Gulbenkian AR et al. | Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. | 1990 | Am. Rev. Respir. Dis. | pmid:2117872 |
Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |