Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
| Ozaki Y et al. | A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. | 1986 | Biochem. Pharmacol. | pmid:3021173 |
| Okamoto M et al. | FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. | 1986 | J. Antibiot. | pmid:3082838 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| DeFeudis FV | Studies on endothelium-dependent vasorelaxation. | 1986 | Gen. Pharmacol. | pmid:3512363 |
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Conrad GW and Rink TJ | Platelet activating factor raises intracellular calcium ion concentration in macrophages. | 1986 | J. Cell Biol. | pmid:3733874 |
| Imura Y et al. | Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988. | 1986 | Life Sci. | pmid:3741541 |
| Kertscher HP and Ostermann G | [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. | 1986 | Pharmazie | pmid:3786385 |
| Powling MJ and Hardisty RM | Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2+. | 1986 | Thromb. Res. | pmid:3787566 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
| O'Flaherty JT et al. | Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. | 1986 | J. Immunol. | pmid:3095426 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Okamoto M et al. | Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. | 1986 | Thromb. Res. | pmid:3754990 |
| Villamediana LM et al. | Effects of the platelet-activating factor antagonist BN 52021 on the hemodynamics of rats with experimental cirrhosis of the liver. | 1986 | Life Sci. | pmid:3755490 |
| Garay R and Braquet P | Involvement of K+ movements in the membrane signal induced by PAF-acether. | 1986 | Biochem. Pharmacol. | pmid:3755602 |
| Pfueller SL and David R | Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia. | 1986 | Br. J. Haematol. | pmid:3756098 |
| Hoffman DR et al. | Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. | 1986 | Cancer Res. | pmid:3756924 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Roubin R et al. | Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. | 1986 | J. Immunol. | pmid:3950403 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| D'Humières S et al. | PAF-acether-induced synthesis of prostacyclin by human endothelial cells. | 1986 | Eur. J. Pharmacol. | pmid:3102256 |
| Chung KF et al. | Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3005546 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
| Baranes J et al. | The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021. | 1986 | Pharmacol Res Commun | pmid:3763677 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Cox CP | Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. | 1986 | Thromb. Res. | pmid:2421432 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. | 1986 | Chem. Pharm. Bull. | pmid:2421923 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:2421924 |
| Herrmann DB et al. | Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3947667 |
| Robertson DN and Smith GM | CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. | 1986 | Eur. J. Pharmacol. | pmid:3709663 |
| Söling HD and Fest W | Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues. | 1986 | J. Biol. Chem. | pmid:3095313 |
| Ostermann G et al. | The role of lipoproteins in the degradation of platelet-activating factor. | 1986 | Thromb. Res. | pmid:3798402 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| Bussolino F et al. | Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. | 1986 | Acta Haematol. | pmid:3019063 |
| McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
| Wallace JL and Whittle BJ | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. | 1986 | Br. J. Pharmacol. | pmid:3096408 |
| Yoshida J et al. | A platelet-aggregating and hypotensive phospholipid isolated from bovine brain. | 1986 | J. Pharm. Pharmacol. | pmid:2880959 |
| Kawaguchi H and Yasuda H | Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3081036 |
| Di Marzo V et al. | The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs. | 1986 | Biochem. Int. | pmid:2432897 |
| Ramesha CS and Pickett WC | Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. | 1986 | J. Biol. Chem. | pmid:3096991 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. | 1986 | Hypertension | pmid:3081442 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
| Sanchez Crespo M et al. | Evidence of a role for PAF-acether in the pathophysiology of the shock state. | 1986 | Pharmacol Res Commun | pmid:3774844 |
| Adnot S et al. | Interference of BN 52021, a PAF-acether antagonist, with endotoxin-induced hypotension in the guinea-pig. | 1986 | Pharmacol Res Commun | pmid:3774845 |
| Rainsford KD | Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. | 1986 | Pharmacol Res Commun | pmid:3774846 |
| Page CP and Morley J | Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma. | 1986 | Pharmacol Res Commun | pmid:3774847 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Hwang SB et al. | Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. | 1986 | J. Biol. Chem. | pmid:3001070 |
| Buxton DB et al. | Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | J. Biol. Chem. | pmid:3001074 |
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Masugi F et al. | Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. | 1985 Sep-Oct | Hypertension | pmid:4030044 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
| Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
| Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
| Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
| Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Hayashi H et al. | Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. | 1985 | J. Biochem. | pmid:2993272 |
| Avdonin PV et al. | Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994653 |
| Ribbes G et al. | Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. | 1985 | FEBS Lett. | pmid:3932094 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| O'Neill C | Examination of the causes of early pregnancy-associated thrombocytopenia in mice. | 1985 | J. Reprod. Fertil. | pmid:3989801 |
| Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Pirotzky E et al. | A role for Paf-acether (platelet-activating factor) in acute skin inflammation? | 1985 | Br. J. Dermatol. | pmid:4015984 |
| Ohno M et al. | An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. | 1985 | Chem. Pharm. Bull. | pmid:4017109 |
| Suemune H et al. | Synthetic studies on platelet-activating factor (PAF). | 1985 | Chem. Pharm. Bull. | pmid:4028291 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Handley DA et al. | Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. | 1985 | Thromb. Haemost. | pmid:4089809 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Vigo C | Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. | 1985 | J. Biol. Chem. | pmid:3919022 |
| Orlov SM et al. | [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. | 1985 | Biokhimiia | pmid:2408682 |
| Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |