Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kurashima K et al. | The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils. | 1996 | Lab. Invest. | pmid:8941214 |
| Libert C et al. | alpha1-Antitrypsin inhibits the lethal response to TNF in mice. | 1996 | J. Immunol. | pmid:8943423 |
| Rosenthal J et al. | Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox. | 1996 | Blood | pmid:8943869 |
| Kitchen E et al. | Demonstration of reversible priming of human neutrophils using platelet-activating factor. | 1996 | Blood | pmid:8943870 |
| Frenkel RA et al. | The biochemical role of platelet-activating factor in reproduction. | 1996 | Prog. Lipid Res. | pmid:8944225 |
| Botha AJ et al. | Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure. | 1996 | Br J Surg | pmid:8944457 |
| Kalra VK et al. | Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | 1996 | Am. J. Physiol. | pmid:8945922 |
| Kelly KJ et al. | An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. | 1996 | Am. J. Physiol. | pmid:8946001 |
| Packard MG et al. | Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory. | 1996 | Neurobiol Learn Mem | pmid:8946410 |
| Dupuis F et al. | PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells. | 1996 | Cancer Lett. | pmid:8947513 |
| Liu XH et al. | The platelet-activating factor antagonist BN 52021 attenuates hypoxic-ischemic brain injury in the immature rat. | 1996 | Pediatr. Res. | pmid:8947953 |
| Fouda SI et al. | Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2. | 1995 | Biochem. J. | pmid:8948437 |
| Sagara H et al. | [PAF receptor antagonist in asthma therapy]. | 1996 | Nippon Rinsho | pmid:8950954 |
| Yanoshita R et al. | Inhibition of lysoPAF acetyltransferase activity by flavonoids. | 1996 | Inflamm. Res. | pmid:8951505 |
| Bhatia AM et al. | Developmental susceptibility to intestinal injury by platelet-activating factor in the newborn rat. | 1996 Sep-Oct | J Invest Surg | pmid:8951658 |
| Lin CC et al. | Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. | 1996 | J Pharm Biomed Anal | pmid:8951694 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| Mavromoustakos T et al. | The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine. | 1996 | Chem. Phys. Lipids | pmid:8952050 |
| Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
| Howard AD and Erickson KL | Alteration of macrophage responsiveness to platelet-activating factor by interferon-gamma and lipopolysaccharide. | 1996 | Cell. Immunol. | pmid:8954615 |
| Noel AA et al. | Platelet-activating factor and nitric oxide mediate microvascular permeability in ischemia-reperfusion injury. | 1996 | Microvasc. Res. | pmid:8954863 |
| Iwahisa Y et al. | Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs. | 1996 | Jpn. J. Pharmacol. | pmid:8957681 |
| Wiebe SH et al. | Osteoclast activation in inflammatory periodontal diseases. | 1996 | Oral Dis | pmid:8957930 |
| Tiemann U et al. | Effect of ATP and platelet-activating factor on intracellular calcium concentrations of cultured oviductal cells from cows. | 1996 | J. Reprod. Fertil. | pmid:8958821 |
| Stoddart NR et al. | Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos. | 1996 | J. Reprod. Fertil. | pmid:8958827 |
| Jarvis GE et al. | The role of ADP in endotoxin-induced equine platelet activation. | 1996 | Eur. J. Pharmacol. | pmid:8960885 |
| Izzo AA | PAF and the digestive tract. A review. | 1996 | J. Pharm. Pharmacol. | pmid:8961155 |
| Minhas BS et al. | Platelet activating factor and conception. | 1996 | Am. J. Reprod. Immunol. | pmid:8962659 |
| Roudebush WE et al. | Effect of platelet-activating factor (PAF) on preimplantation mouse B6D2F1/J embryo formation. | 1996 | Am. J. Reprod. Immunol. | pmid:8962660 |
| Sagara H et al. | Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils. | 1996 | Clin. Exp. Allergy | pmid:8963871 |
| Despotis GJ et al. | Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. | 1996 | Anesthesiology | pmid:8968178 |
| West RR et al. | ZG-1494 alpha, a novel platelet-activating factor acetyltransferase inhibitor from Penicillium rubrum, isolation, structure elucidation andbiological activity. | 1996 | J. Antibiot. | pmid:8968388 |
| Liu L et al. | Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8969272 |
| Tokumura A et al. | Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipids. | 1996 | Lipids | pmid:8972457 |
| Terada N et al. | The effect of anti-VLA-4 monoclonal antibody on eosinophil accumulation and leukotriene production in nasal mucosa. | 1996 | Acta Otolaryngol. | pmid:8973726 |
| Bkaily G et al. | Modulation of cardiac cell Ca2+ currents by PAF. | 1996 | Blood Press Suppl | pmid:8973773 |
| Sugano M et al. | Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists. | 1996 | J. Med. Chem. | pmid:8978857 |
| Anderson R et al. | Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils. | 1996 | Inflammation | pmid:8979156 |
| Williams FM | Neutrophils and myocardial reperfusion injury. | 1996 | Pharmacol. Ther. | pmid:8981567 |
| Dentener MA et al. | Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. | 1997 | J. Infect. Dis. | pmid:8985203 |
| Ho YS et al. | Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. | 1997 | Nature | pmid:8985254 |
| MonteseirÃn J et al. | Formation of lipids, peptides and cytokines. | 1996 Sep-Oct | Allergol Immunopathol (Madr) | pmid:8985477 |
| Michibayashi T | [Vascular responsiveness of platelet activating factor--with special reference to its action in the presence of platelets]. | 1996 | J Smooth Muscle Res | pmid:8985919 |
| de Boissieu D et al. | Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets. | 1996 | J. Pediatr. Surg. | pmid:8986985 |
| Ferreira MG and Fonteles MC | Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8987112 |
| Ohtani N and Asano G | [Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8987363 |
| Laniyonu AA et al. | Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. | 1997 | Shock | pmid:8989836 |
| Tuomanen EI | Molecular and cellular mechanisms of pneumococcal meningitis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993350 |
| Misra UK et al. | Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. | 1997 | J. Biol. Chem. | pmid:8995289 |
| Merlos M et al. | Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). | 1997 | J. Pharmacol. Exp. Ther. | pmid:8996188 |
| Sugatani J et al. | High-density lipoprotein inhibits the synthesis of platelet-activating factor in human vascular endothelial cells. | 1996 | J Lipid Mediat Cell Signal | pmid:8998599 |
| Dagenais P et al. | Augmented expression of platelet-activating factor receptor gene by TNF-alpha through transcriptional activation in human monocytes. | 1997 | J. Leukoc. Biol. | pmid:9000543 |
| O'Neill C | Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro. | 1997 | Biol. Reprod. | pmid:9002654 |
| Vavilova GL et al. | [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. | 1996 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9005660 |
| Souza-Fiho MV et al. | Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. | 1997 | Am. J. Pathol. | pmid:9006340 |
| Ohyama T et al. | Sensitive densitometry for the determination of platelet-activating factor and other phospholipids in human tears. | 1996 | Analyst | pmid:9008409 |
| Ishii S et al. | Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. | 1997 | EMBO J. | pmid:9009274 |
| Camussi G et al. | Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages. | 1997 | J. Immunol. | pmid:9013973 |
| Chakrabarti R et al. | Alteration of platelet-activating factor-induced signal transduction in macrophages by n-3 fatty acids. | 1997 | Cell. Immunol. | pmid:9015191 |
| Maclennan KM et al. | Platelet-activating factor in the CNS. | 1996 | Prog. Neurobiol. | pmid:9015828 |
| Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
| Ohmori T et al. | In vitro hypoxia of cortical and hippocampal CA1 neurons: glutamate, nitric oxide, and platelet activating factor participate in the mechanism of selective neural death in CA1 neurons. | 1996 | Brain Res. | pmid:9017237 |
| Bazan NG et al. | Bioactive lipids in excitatory neurotransmission and neuronal plasticity. | 1997 | Neurochem. Int. | pmid:9017670 |
| Fukuda AI and Breuel KF | Effect of platelet activating factor on embryonic development and implantation in the mouse. | 1996 | Hum. Reprod. | pmid:9021383 |
| Lee DR et al. | Induction of acrosome reaction in human spermatozoa accelerates the time of pronucleus formation of hamster oocytes after intracytoplasmic sperm injection. | 1997 | Fertil. Steril. | pmid:9022609 |
| Riera M et al. | Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023292 |
| Vlasova II et al. | [Effect of a micellar preparation of polyunsaturated phosphatidylcholine on platelet aggregation in vitro]. | 1996 | Biull Eksp Biol Med | pmid:9026131 |
| He J et al. | Micellar electrokinetic capillary chromatographic analysis of platelet activating factor in human blood by indirect ultraviolet detection. | 1996 | Ann. Ist. Super. Sanita | pmid:9028060 |
| Denizot Y et al. | PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. | 1996 | J Lipid Mediat Cell Signal | pmid:9029369 |
| Bleivik B et al. | Protein kinase C inhibitors and PAF stimulate phosphatidylserine synthesis in human leucocytes. | 1996 | J Lipid Mediat Cell Signal | pmid:9029372 |
| Packham MA et al. | Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:9029375 |
| Comminges C et al. | Studies on ether-phospholipids of vascular smooth muscle cells. Identification of a rapid Ca(2+)-dependent hydrolysis of alkyl-phosphatidylethanolamine promoted by endothelin-l. | 1997 | Biochim. Biophys. Acta | pmid:9030203 |
| Karpouza AP and Vakirtzi-Lemonias C | The platelet-activating factor acetylhydrolase of mouse platelets. | 1997 | Biochim. Biophys. Acta | pmid:9030208 |
| Koenderman L | Priming of circulating human eosinophils following late response to allergen challenge. | 1997 | Eur. Respir. J. | pmid:9032524 |
| Hotter G et al. | Free radical enhancement promotes leucocyte recruitment through a PAF and LTB4 dependent mechanism. | 1997 | Free Radic. Biol. Med. | pmid:9034233 |
| Herbertson MJ et al. | Platelet-activating factor antagonism improves ventricular contractility in endotoxemia. | 1997 | Crit. Care Med. | pmid:9034254 |
| Yoshikawa T et al. | Role of superoxide and nitric oxide in platelet-activating factor-induced acute lung injury, hypotension, and mortality in rats. | 1997 | Crit. Care Med. | pmid:9034266 |
| Herbert JM et al. | Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat. | 1997 | J Lipid Mediat Cell Signal | pmid:9034959 |
| Binisti C et al. | Structure-activity relationships in platelet activating factor. 9. From PAF-antagonism to PLA2 inhibition. | 1997 | J Lipid Mediat Cell Signal | pmid:9034960 |
| Tavet F et al. | Design and modeling of new platelet-activating factor antagonists. 2. Synthesis and biological activity of 1,4-bis-(3',4',5'-trimethoxybenzoyl)-2-alkyl and 2-alkyloxymethylpiperazines. | 1997 | J Lipid Mediat Cell Signal | pmid:9034961 |
| Heymans F et al. | Design and modeling of new platelet-activating factor antagonists. 3. Relative importance of hydrophobicity and electronic distribution in piperazinic series. | 1997 | J Lipid Mediat Cell Signal | pmid:9034962 |
| Massicot F et al. | Preventive effects of two PAF-antagonists, PMS 536 and PMS 549, on cyclosporin-induced LLC-PK1 oxidative injury. | 1997 | J Lipid Mediat Cell Signal | pmid:9034965 |
| Morozova NG et al. | [Synthesis of cationic alkylglucosides]. | 1996 Oct-Nov | Bioorg. Khim. | pmid:9036840 |
| Le Gouill C et al. | Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. | 1997 | FEBS Lett. | pmid:9037196 |
| Barden A et al. | Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. | 1997 | Clin. Sci. | pmid:9038589 |
| Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
| Brzustowicz LM et al. | Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts. | 1997 | Hypertension | pmid:9039096 |
| Izzo AA and Benveniste J | Presence of paf-acether in human blood after thin-layer chromatography, but not after high-performance liquid chromatography purification. | 1996 | J Pharmacol Toxicol Methods | pmid:9040113 |
| Feuerstein G et al. | Platelet-activating factor and cardiac diseases: therapeutic potential for PAF inhibitors. | 1997 | J Lipid Mediat Cell Signal | pmid:9041476 |
| Dohi T et al. | Stimulation of platelet-activating factor synthesis by neurotransmitters in salivary glands. | 1997 | J. Dent. Res. | pmid:9042079 |
| Bonaccorsi L et al. | Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells. | 1997 | Biochim. Biophys. Acta | pmid:9042336 |
| Chang TW | Improvement of survival from hemorrhagic shock by enterectomy in rats: finding to implicate the role of the gut for irreversibility of hemorrhagic shock. | 1997 | J Trauma | pmid:9042872 |
| Saitoh C et al. | Effect of YM934, a KATP channel opener, on airway hyperresponsiveness induced by platelet activating factor in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050013 |
| Lin CH et al. | The effect of the selective PAF antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050014 |
| Gruska S et al. | Prevalence of increased intracellular signal transduction in immortalized lymphoblasts from patients with essential hypertension and normotensive subjects. | 1997 | J. Hypertens. | pmid:9050967 |
| Rodriguez-Barbero A et al. | Involvement of platelet-activating factor in gentamicin nephrotoxicity in rats. | 1997 Jan-Feb | Exp. Nephrol. | pmid:9052848 |
| Forde RC and Fitzgerald DJ | Reactive oxygen species and platelet activation in reperfusion injury. | 1997 | Circulation | pmid:9054729 |
| Collins LC and Roberts AM | Effects of platelet-activating factor on arteriolar and venular tone in rat trachea. | 1997 | Microvasc. Res. | pmid:9056476 |
| Clinical studies of IL-11, new platelet growth factor, presented. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9057177 | |
| Anderson MR and Blumer JL | Advances in the therapy for sepsis in children. | 1997 | Pediatr. Clin. North Am. | pmid:9057790 |