Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Downing SJ et al. | Effect of inflammatory mediators on the physiology of the human Fallopian tube. | 2002 | Hum Fertil (Camb) | pmid:12082208 |
| Jaracz S et al. | Ginkgolides: selective acetylations, translactonization, and biological evaluation. | 2002 | J. Org. Chem. | pmid:12076171 |
| Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
| Nakamura T et al. | Relationship between the platelet activating factor acetylhydrolase gene and intractability of ulcerative colitis. | 2002 | Dis. Colon Rectum | pmid:12068200 |
| Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Lloberas N et al. | Postischemic renal oxidative stress induces inflammatory response through PAF and oxidized phospholipids. Prevention by antioxidant treatment. | 2002 | FASEB J. | pmid:12039876 |
| Honda Z et al. | Platelet-activating factor receptor. | 2002 | J. Biochem. | pmid:12038971 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Iatrou C et al. | Is platelet-activating factor produced during hemodialysis with AN-69 polyacrylonitrile membrane? | 2002 | Nephron | pmid:12021524 |
| Michalis LK et al. | Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. | 2002 | Curr Med Res Opin | pmid:12017208 |
| Ottino P et al. | Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. | 2002 | Exp. Eye Res. | pmid:12014920 |
| Zhang J et al. | Effect of buyang huanwu decoction on platelet activating factor content in arterial blood pre- and post-arterial thrombosis in rats. | 2001 | J Tradit Chin Med | pmid:12014136 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Zimmerman GA et al. | The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. | 2002 | Crit. Care Med. | pmid:12004251 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| McManus LM and Pinckard RN | PAF, a putative mediator of oral inflammation. | 2000 | Crit. Rev. Oral Biol. Med. | pmid:12002818 |
| Kalkanci A et al. | The role of tumour necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) interaction on murine candidosis. | 2002 | Mycoses | pmid:12000505 |
| Borgquist JD et al. | Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. | 2002 | J. Leukoc. Biol. | pmid:11994500 |
| Varon D and Brill A | Platelets cross-talk with tumor cells. | 2001 | Haemostasis | pmid:11990484 |
| Börjesson A et al. | Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats. | 2002 | Dig Liver Dis | pmid:11990391 |
| Wang LS et al. | Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. | 2002 | Scand. J. Gastroenterol. | pmid:11989839 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Jerkić M et al. | The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. | 2001 | Int Urol Nephrol | pmid:11989542 |
| de Souza LJ et al. | Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis. | 2001 Jul-Aug | J. Gastrointest. Surg. | pmid:11985976 |
| Roudebush WE et al. | Embryonic platelet-activating factor: an indicator of embryo viability. | 2002 | Hum. Reprod. | pmid:11980756 |
| McKay CJ | Recent developments in the management of acute pancreatitis. | 2002 | Dig Surg | pmid:11979001 |
| Steel HC and Anderson R | Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium. | 2002 | Br. J. Pharmacol. | pmid:11976271 |
| Boisfer E et al. | Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II. | 2002 | J. Lipid Res. | pmid:11971944 |
| Hostettler ME et al. | Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3. | 2002 | Glia | pmid:11968060 |
| Bernatchez PN et al. | Relative effects of VEGF-A and VEGF-C on endothelial cell proliferation, migration and PAF synthesis: Role of neuropilin-1. | 2002 | J. Cell. Biochem. | pmid:11968003 |
| Castellvi J et al. | Effect of the platelet-activating factor antagonist BN-52021 on liver preservation (4 degrees): experimental study in isolated reperfused rat liver model. | 2002 | Transplant. Proc. | pmid:11959181 |
| Lloberas N et al. | The ether phospholipids trail: blood timing in renal ischemia-reperfusion injury. | 2002 | Transplant. Proc. | pmid:11959179 |
| Fragopoulou E et al. | Biologically active lipids with antiatherogenic properties from white wine and must. | 2002 | J. Agric. Food Chem. | pmid:11958642 |
| Calcerrada MC et al. | PAF-stimulated protein tyrosine phosphorylation in hippocampus: involvement of NO synthase. | 2002 | Neurochem. Res. | pmid:11958533 |
| Roudebush WE et al. | Embryonic platelet-activating factor: temporal expression of the ligand and receptor. | 2002 | J. Assist. Reprod. Genet. | pmid:11958508 |
| Xu N et al. | Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944906 |
| Strait RT et al. | Pathways of anaphylaxis in the mouse. | 2002 | J. Allergy Clin. Immunol. | pmid:11941316 |
| Deo DD et al. | Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism. | 2002 | J. Biol. Chem. | pmid:11940567 |
| Kingston JK et al. | Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. | 2002 | Am. J. Vet. Res. | pmid:11939312 |
| Tachibana A et al. | Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor. | 2002 | Intervirology | pmid:11937770 |
| Silva AR et al. | Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. | 2002 | J. Immunol. | pmid:11937571 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Larrucea S et al. | Agonist-induced aggregation of Chinese hamster ovary cells coexpressing the human receptors for fibrinogen (integrin alphaIIbbeta3) and the platelet-activating factor: dissociation between adhesion and aggregation. | 2002 | Blood | pmid:11929771 |
| Barletta E et al. | Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones. | 2002 | Biol. Chem. | pmid:11928813 |
| Hostettler ME and Carlson SL | PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury. | 2002 | Neuroreport | pmid:11924887 |
| Cellai C et al. | Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. | 2002 | FASEB J. | pmid:11923217 |
| Ozgün H et al. | Lexipafant inhibits postsurgical adhesion formation. | 2002 | J. Surg. Res. | pmid:11922727 |
| Hu G et al. | Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels. | 2002 | Anesth. Analg. | pmid:11916783 |
| Ishiguro K et al. | Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension. | 2002 | Planta Med. | pmid:11914965 |
| Ko HM et al. | Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis. | 2002 | Cancer Res. | pmid:11912159 |
| Royal SJ et al. | Laminar disorganisation of mitral cells in the olfactory bulb does not affect topographic targeting of primary olfactory axons. | 2002 | Brain Res. | pmid:11911856 |
| Schwartzkopff F et al. | The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor. | 2002 | J. Interferon Cytokine Res. | pmid:11911809 |
| McClenahan DJ et al. | In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. | 2002 | Am. J. Vet. Res. | pmid:11911574 |
| Matorras R and Pijoan JI | The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904634 |
| Kondratskaya EL et al. | BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. | 2002 | Neurochem. Int. | pmid:11900860 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Teruel MN and Meyer T | Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. | 2002 | Science | pmid:11884760 |
| Klein A et al. | Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. | 2002 | Br. J. Pharmacol. | pmid:11877329 |
| Mio T et al. | Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels. | 2002 | J. Lab. Clin. Med. | pmid:11873241 |
| Tanaka Y et al. | Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor. | 2002 | J. Autoimmun. | pmid:11869042 |
| Küçükhüseyin C et al. | Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms. | 2001 | J Basic Clin Physiol Pharmacol | pmid:11868905 |
| Breschi MC et al. | Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. | 2002 | Eur. J. Pharmacol. | pmid:11864645 |
| Ottino P and Bazan HE | Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. | 2001 | Curr. Eye Res. | pmid:11840344 |
| Barabé F et al. | Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils. | 2002 | J. Biol. Chem. | pmid:11839753 |
| Tibiriçá E | Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants. | 2001 | Cardiovasc Drug Rev | pmid:11830750 |
| Claing A et al. | Comparison of the contractile and calcium-increasing properties of platelet-activating factor and endothelin-1 in the rat mesenteric artery and vein. | 2002 | Br. J. Pharmacol. | pmid:11815379 |
| Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
| Drost EM and MacNee W | Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis. | 2002 | Eur. J. Immunol. | pmid:11813158 |
| Johansson S et al. | A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. | 2002 | J. Nat. Prod. | pmid:11809061 |
| Unno N et al. | Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. | 2002 | Ann. Surg. | pmid:11807372 |
| Ribeiro JM and Francischetti IM | Platelet-activating-factor-hydrolyzing phospholipase C in the salivary glands and saliva of the mosquito Culex quinquefasciatus. | 2001 | J. Exp. Biol. | pmid:11807106 |
| Walterscheid JP et al. | Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. | 2002 | J. Exp. Med. | pmid:11805144 |
| Cheminade C et al. | 1-O-alkylglycerols improve boar sperm motility and fertility. | 2002 | Biol. Reprod. | pmid:11804958 |
| Shah BH et al. | Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. | 2001 | Exp. Mol. Med. | pmid:11795484 |
| Roudebush WE et al. | Relationship between platelet-activating factor concentration in rhesus monkey (Macaca mulatta) spermatozoa and sperm motility. | 2002 | Am. J. Primatol. | pmid:11793409 |
| Nagase T et al. | Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11790655 |
| Ohshima N et al. | Receptor-dependent metabolism of platelet-activating factor in murine macrophages. | 2002 | J. Biol. Chem. | pmid:11786559 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Hanada K et al. | Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy. | 2002 | J. Exp. Med. | pmid:11781362 |
| Ichinowatari G et al. | Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6. | 2002 | Eur. J. Pharmacol. | pmid:11779582 |
| Zhu W et al. | Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs. | 2000 | Chin. Med. J. | pmid:11776064 |
| Añel RL and Kumar A | Experimental and emerging therapies for sepsis and septic shock. | 2001 | Expert Opin Investig Drugs | pmid:11772263 |
| Closa D et al. | Absorption and effects of 3-(N-phenylamino)-1,2-propanediol esters in relation to toxic oil syndrome. | 2001 | Lipids | pmid:11768157 |
| Rivera A et al. | Modulation of Gardos channel activity by cytokines in sickle erythrocytes. | 2002 | Blood | pmid:11756192 |
| Uhlmann D et al. | Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. | 2001 | Zentralbl Chir | pmid:11753796 |
| Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
| Stangl V et al. | Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion. | 2002 | Cardiovasc. Res. | pmid:11744010 |
| Binisti C et al. | Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. | 2001 | Eur J Med Chem | pmid:11738488 |
| McHowat J et al. | Endothelial cell PAF synthesis following thrombin stimulation utilizes Ca(2+)-independent phospholipase A(2). | 2001 | Biochemistry | pmid:11732912 |
| de Meis L | Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. | 2001 | Biosci. Rep. | pmid:11725862 |
| Caplan MS and Jilling T | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. | 2001 | Lipids | pmid:11724457 |