| MeSH term | MeSH ID | Detail |
|---|---|---|
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Aggressive Periodontitis | D010520 | 8 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Fetal Growth Retardation | D005317 | 9 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Salmonella Infections, Animal | D012481 | 9 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
| Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Okamoto M et al. | Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. | 1986 | Thromb. Res. | pmid:3754990 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Oh-ishi S et al. | Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3829203 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Piper PJ and Stewart AG | Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. | 1986 | Br. J. Pharmacol. | pmid:3091131 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
| Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Mikashima H et al. | An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. | 1987 | Jpn. J. Pharmacol. | pmid:2890779 |
| Gautheron PD et al. | A study of PAF-induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L-652,731. | 1987 | J. Pharm. Pharmacol. | pmid:2891830 |
| McFall TL et al. | Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. | 1987 | Pediatr. Res. | pmid:3037472 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| Kumar R et al. | Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. | 1987 | Biochim. Biophys. Acta | pmid:3790610 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Terasawa M et al. | Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. | 1987 | Jpn. J. Pharmacol. | pmid:3682404 |
| Sipka S et al. | Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils. | 1987 | Acta Biochim. Biophys. Hung. | pmid:3132002 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
| Egido J et al. | Role of platelet-activating factor in adriamycin-induced nephropathy in rats. | 1987 | Eur. J. Pharmacol. | pmid:3622604 |
| Kawaguchi H and Yasuda H | Effects of platelet-activating factor on conversion of angiotensin I to II. | 1987 | FEBS Lett. | pmid:3622769 |
| Ninio E et al. | Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. | 1987 | J. Immunol. | pmid:3584983 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
| Casals-Stenzel J et al. | Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | 1987 | Br. J. Pharmacol. | pmid:3664079 |
| Robertson DN and Page CP | Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. | 1987 | Br. J. Pharmacol. | pmid:3664082 |
| Whittle BJ et al. | Increased intestinal formation of Paf in endotoxin-induced damage in the rat. | 1987 | Br. J. Pharmacol. | pmid:3664090 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
| Tahara T et al. | PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines. | 1987 | Chem. Pharm. Bull. | pmid:3664818 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| O'Neill C | Embryo-derived platelet activating factor: a preimplantation embryo mediator of maternal recognition of pregnancy. | 1987 | Domest. Anim. Endocrinol. | pmid:3333935 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
| Bossant MJ et al. | Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. | 1987 | J. Chromatogr. | pmid:3443654 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
| Leff AR et al. | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. | 1987 | J. Appl. Physiol. | pmid:2881917 |
| Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
| Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |
| Alloatti G et al. | Protective effect of verapamil on the cardiac and circulatory alterations induced by platelet-activating factor. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2435996 |
| Kappa JR et al. | Carotid endarterectomy in patients with heparin-induced platelet activation: comparative efficacy of aspirin and iloprost (ZK36374). | 1987 | J. Vasc. Surg. | pmid:2437338 |
| Serafin WE and Austen KF | Mediators of immediate hypersensitivity reactions. | 1987 | N. Engl. J. Med. | pmid:2438554 |
| Avdonin PV et al. | Evidence for the receptor-operated calcium channels in human platelet plasma membrane. | 1987 | Thromb. Res. | pmid:2438805 |
| Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Michel L et al. | Biologic properties of LTB4 and paf-acether in vivo in human skin. | 1987 | J. Invest. Dermatol. | pmid:3035030 |
| Shalit M et al. | Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly. | 1987 | Blood | pmid:3118991 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Sheth KJ et al. | Reversal of central nervous system involvement in hemolytic uremic syndrome by use of plasma exchanges. | 1987 | Clin Pediatr (Phila) | pmid:3119270 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Sage SO and Rink TJ | The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets. | 1987 | J. Biol. Chem. | pmid:3119586 |
| Camussi G et al. | Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor. | 1987 | J. Exp. Med. | pmid:3119758 |
| Satouchi K et al. | 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. | 1987 | Lipids | pmid:3110532 |
| Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |