| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thalassemia | D013789 | 8 associated lipids |
| Thrombasthenia | D013915 | 4 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Toxemia | D014115 | 3 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Uveitis, Anterior | D014606 | 11 associated lipids |
| Ventricular Fibrillation | D014693 | 16 associated lipids |
| Viremia | D014766 | 4 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Dementia, Multi-Infarct | D015161 | 2 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Macconi D et al. | PAF mediates neutrophil adhesion to thrombin or TNF-stimulated endothelial cells under shear stress. | 1995 | Am. J. Physiol. | pmid:7631759 |
| Hines KL and Fisher RA | Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis. | 1992 | Am. J. Physiol. | pmid:1375439 |
| Kubes P et al. | Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine. | 1995 | Am. J. Physiol. | pmid:7631799 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
| Rioux KP and Wallace JL | Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism. | 1994 | Am. J. Physiol. | pmid:8203531 |
| Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
| Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Khoury J and Langleben D | Platelet-activating factor stimulates lung pericyte growth in vitro. | 1996 | Am. J. Physiol. | pmid:8780000 |
| Zimmerman BJ et al. | Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. | 1994 | Am. J. Physiol. | pmid:8160832 |
| Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
| Suematsu M et al. | In vivo visualization of oxidative changes in microvessels during neutrophil activation. | 1993 | Am. J. Physiol. | pmid:8096123 |
| Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
| Del Maschio A et al. | Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. | 1990 | Am. J. Physiol. | pmid:2156456 |
| Asako H et al. | Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery. | 1992 | Am. J. Physiol. | pmid:1362329 |
| DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |
| Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
| Yamazaki M et al. | Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. | 1991 | Am. J. Physiol. | pmid:1653524 |
| Hasunuma K et al. | Endothelin 1 causes pulmonary vasodilation in rats. | 1990 | Am. J. Physiol. | pmid:2115743 |
| Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
| Kubes P et al. | Platelet-activating factor-induced mucosal dysfunction: role of oxidants and granulocytes. | 1991 | Am. J. Physiol. | pmid:1647676 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
| Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
| Reinhardt PH et al. | Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. | 1996 | Am. J. Physiol. | pmid:8772427 |
| Halonen M et al. | Anatomic basis for species differences in peripheral lung strip contraction to PAF. | 1990 | Am. J. Physiol. | pmid:2382734 |
| Sun XM et al. | Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. | 1996 | Am. J. Physiol. | pmid:8772517 |
| Neuwirth R et al. | Extra- and intracellular metabolism of platelet-activating factor by cultured mesangial cells. | 1989 | Am. J. Physiol. | pmid:2705543 |
| Kinnula VL et al. | Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro. | 1992 | Am. J. Physiol. | pmid:1616055 |
| Kim D and Durán WN | Platelet-activating factor stimulates protein tyrosine kinase in hamster cheek pouch microcirculation. | 1995 | Am. J. Physiol. | pmid:7530921 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Kurtel H et al. | Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion. | 1995 | Am. J. Physiol. | pmid:7541957 |
| Wood JG et al. | Gastric microvascular actions of platelet-activating factor: role of leukocytes. | 1992 | Am. J. Physiol. | pmid:1550241 |
| Zheng ZG et al. | Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. | 1993 | Am. J. Physiol. | pmid:8430791 |
| Conyers G et al. | A factor in serum lowers resistance and opens tight junctions of MDCK cells. | 1990 | Am. J. Physiol. | pmid:2221039 |
| Kvietys PR et al. | Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. | 1990 | Am. J. Physiol. | pmid:2221068 |
| Harris NR et al. | Capillary filtration during acute inflammation: role of adherent neutrophils. | 1993 | Am. J. Physiol. | pmid:7902014 |
| Kalra VK et al. | Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | 1996 | Am. J. Physiol. | pmid:8945922 |
| Kelly KJ et al. | An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. | 1996 | Am. J. Physiol. | pmid:8946001 |
| Gallin EK | Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. | 1989 | Am. J. Physiol. | pmid:2750892 |
| Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Ferrer-Lopez P et al. | Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G. | 1990 | Am. J. Physiol. | pmid:2360620 |
| Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
| Handa RK et al. | Platelet-activating factor is a renal vasodilator in the anesthetized rat. | 1990 | Am. J. Physiol. | pmid:2360650 |
| Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
| Huang YC et al. | Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung. | 1994 | Am. J. Physiol. | pmid:7513130 |
| Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
| Zhou W et al. | Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. | 1992 | Am. J. Physiol. | pmid:1443133 |
| Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Bienvenu K et al. | Modulation of leukocyte migration in mesenteric interstitium. | 1994 | Am. J. Physiol. | pmid:7943404 |
| Church DJ et al. | Calcium influx in platelet activating factor-induced atrial natriuretic peptide release in rat cardiomyocytes. | 1994 | Am. J. Physiol. | pmid:8166260 |
| Perico N et al. | Platelet-activating factor alters glomerular barrier size selectivity for macromolecules in rats. | 1991 | Am. J. Physiol. | pmid:1713421 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Kornecki E and Ehrlich YH | Diminished responsiveness of human platelets to platelet-activating factor during pregnancy. | 1990 | Am. J. Physiol. | pmid:2396687 |
| Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
| Rabe KF et al. | Contraction of human bronchial smooth muscle caused by activated human eosinophils. | 1994 | Am. J. Physiol. | pmid:7943259 |
| Koyama S et al. | Type II pneumocytes release chemoattractant activity for monocytes constitutively. | 1997 | Am. J. Physiol. | pmid:9176245 |
| Dobrowsky RT et al. | Effect of SRI 63-675 on hemodynamics and blood PAF levels during porcine endotoxemia. | 1991 | Am. J. Physiol. | pmid:2035668 |
| Chang SW et al. | Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor. | 1989 | Am. J. Physiol. | pmid:2801951 |
| Mózes T et al. | Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. | 1989 | Am. J. Physiol. | pmid:2802004 |
| Kobayashi I et al. | Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. | 1994 | Am. J. Physiol. | pmid:8160825 |
| Hines KL et al. | PAF increases hepatic vascular resistance and glycogenolysis in vivo. | 1991 | Am. J. Physiol. | pmid:1848410 |
| Schlondorff D et al. | Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. | 1989 | Am. J. Physiol. | pmid:2492160 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Kubes P et al. | Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes. | 1990 | Am. J. Physiol. | pmid:2301577 |
| Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
| Chang SW et al. | Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. | 1990 | Am. J. Physiol. | pmid:2301603 |
| Rainger GE et al. | Adhesion of flowing neutrophils to cultured endothelial cells after hypoxia and reoxygenation in vitro. | 1995 | Am. J. Physiol. | pmid:7485573 |
| Pique JM et al. | Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. | 1990 | Am. J. Physiol. | pmid:2316650 |
| Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
| Sobhani I et al. | Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands. | 1995 | Am. J. Physiol. | pmid:7611410 |
| Marchetti J et al. | The parietal sheet of Bowman's capsule of rat renal glomerulus: a target of endothelin and PAF. | 1995 | Am. J. Physiol. | pmid:7611446 |
| Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Koyama S et al. | Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. | 1995 | Am. J. Physiol. | pmid:7631812 |
| Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
| Miura S et al. | Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid. | 1993 | Am. J. Physiol. | pmid:8498509 |
| Martins MA et al. | Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs. | 1991 | Am. J. Physiol. | pmid:1722649 |
| Duque I et al. | Effects of reactive oxygen species on cultured rat mesangial cells and isolated rat glomeruli. | 1992 | Am. J. Physiol. | pmid:1415575 |
| Johnson A et al. | Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1991 | Am. J. Physiol. | pmid:1656789 |
| Kruse-Elliott KT et al. | Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. | 1992 | Am. J. Physiol. | pmid:1415600 |
| Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
| Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
| Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |