Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hwang SB et al. | Specific receptor sites for 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes. | 1983 | Biochemistry | pmid:6313047 |
| Wasserman SI | Mediators of immediate hypersensitivity. | 1983 | J. Allergy Clin. Immunol. | pmid:6193157 |
| MacIntyre DE and Pollock WK | Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. | 1983 | Biochem. J. | pmid:6411067 |
| Hopkins NK et al. | Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4. | 1983 | Biochim. Biophys. Acta | pmid:6313071 |
| Mencia-Huerta JM et al. | Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. | 1983 | J. Immunol. | pmid:6315819 |
| Czarnetzki B | Increased monocyte chemotaxis towards leukotriene B4 and platelet activating factor in patients with inflammatory dermatoses. | 1983 | Clin. Exp. Immunol. | pmid:6317241 |
| Stimler NP and O'Flaherty JT | Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. | 1983 | Am. J. Pathol. | pmid:6624879 |
| Hartung HP | Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2- production, spreading, and the influence of calmodulin-inhibitor W-7. | 1983 | FEBS Lett. | pmid:6309563 |
| Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
| Shukla SD et al. | Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis. | 1983 | J. Biol. Chem. | pmid:6309795 |
| Hallam TJ et al. | The role of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AcGEPC) and palmitoyl-lysophosphatidate in the responses of human blood platelets to collagen and thrombin. | 1983 | FEBS Lett. | pmid:6617886 |
| Roussi J et al. | [Success of treatment with a low-molecular-weight heparin fraction in a case of pulmonary embolism complicated by heparin-induced thrombopenia]. | 1983 | Nouv Rev Fr Hematol | pmid:6622253 |
| Valone FH and Goetzl EJ | Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC). | 1983 | Am. J. Pathol. | pmid:6624880 |
| Barradas MA et al. | The effect of fenfluramine on collagen-induced platelet aggregation in vitro. | 1983 | Br J Clin Pharmacol | pmid:6626443 |
| Heffner JE et al. | Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. | 1983 | J. Clin. Invest. | pmid:6822668 |
| Keraly CL et al. | Effect of structural analogues of PAF-acether on platelet desensitization. | 1983 | Br. J. Haematol. | pmid:6824590 |
| Tence M et al. | The enantiomer and the positional isomer of platelet-activating factor. | 1983 | Biochim. Biophys. Acta | pmid:6824744 |
| Camussi G et al. | Biosynthesis and release of platelet-activating factor from human monocytes. | 1983 | Int. Arch. Allergy Appl. Immunol. | pmid:6826235 |
| Randolph AE et al. | Blood pressure and heart rate effects of alkyl ether phospholipids in conscious renal, spontaneously hypertensive, and normotensive rats. | 1983 | Clin Exp Hypertens A | pmid:6684006 |
| Morley J et al. | Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin. | 1983 | Br. J. Pharmacol. | pmid:6685552 |
| Hornby EJ and Perry CR | 1-O-hexadecyl-2-acetyl-sn-3-glycerophosphorylcholine (PAF): some effects on the aggregation of human platelets by thrombin or collagen. | 1983 | Thromb. Haemost. | pmid:6636035 |
| Patterson R and Harris KE | The activity of aerosolized and intracutaneous synthetic platelet activating factor (AGEPC) in rhesus monkeys with IgE-mediated airway responses and normal monkeys. | 1983 | J. Lab. Clin. Med. | pmid:6644157 |
| Nunn B | Total and selective desensitisation of human platelets to synthetic platelet activating factor (PAF): evidence that extracellular PAF does not mediate collagen-induced aggregation. | 1983 | Thromb. Res. | pmid:6648898 |
| Myers A et al. | Glucocorticoid protection against PAF-acether toxicity in mice. | 1983 | Br. J. Pharmacol. | pmid:6652344 |
| Cervoni P et al. | Aortic vascular and atrial responses to (+/-)-1-O-octadecyl-2-acetyl-glyceryl-3-phosphorylcholine. | 1983 | Br. J. Pharmacol. | pmid:6652348 |
| Ogihara T et al. | [Renomedullary hypotensive lipids and prostaglandins]. | 1983 | Horumon To Rinsho | pmid:6368051 |
| Benveniste J et al. | The actions of Paf-acether (platelet-activating factor) on guinea-pig isolated heart preparations. | 1983 | Br. J. Pharmacol. | pmid:6652376 |
| Garcia Gil M and Sanchez Crespo M | Dansylcadaverine and rimantadine inhibition of phagocytosis, PAF-acether release, and phosphatidylcholine synthesis in human polymorphonuclear leukocytes. | 1983 | Immunopharmacology | pmid:6654649 |
| Tokumura A et al. | Biphasic action of platelet-activating factor on isolated guinea-pig ileum. | 1983 | Lipids | pmid:6656539 |
| Hamasaki Y et al. | [Effects of platelet activating factor (PAF:AGEPC) on airway and pulmonary vascular constriction of guinea pigs--with special reference to the relation with TXA2]. | 1983 | Kokyu To Junkan | pmid:6658209 |
| Mueller HW et al. | Biosynthesis of platelet activating factor in rabbit polymorphonuclear neutrophils. | 1983 | J. Biol. Chem. | pmid:6406476 |
| Touqui L et al. | Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838557 |
| Billah MM and Johnston JM | Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407483 |
| Worthen GS et al. | Platelet-activating factor causes neutrophil accumulation and edema in rabbit lungs. | 1983 | Chest | pmid:6839840 |
| Heffner JE et al. | Platelet-induced pulmonary hypertension and edema. A mechanism involving acetyl glyceryl ether phosphorylcholine and thromboxane A2. | 1983 | Chest | pmid:6839854 |
| Levy JV | Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor. | 1983 | Proc. Soc. Exp. Biol. Med. | pmid:6844347 |
| O'Flaherty JT et al. | Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6844746 |
| Valone FH and Goetzl EJ | Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine. | 1983 | Immunology | pmid:6848449 |
| Chilton FH et al. | Metabolic fate of platelet-activating factor in neutrophils. | 1983 | J. Biol. Chem. | pmid:6853486 |
| Stormorken H et al. | A new bleeding disorder: lack of platelet aggregatory response to adrenaline and lack of secondary aggregation to ADP and platelet activating factor (PAF). | 1983 | Thromb. Res. | pmid:6857589 |
| Kloprogge E et al. | Stimulus-response coupling in human platelets. Evidence against a role of PAF-acether in the "third pathway'. | 1983 | Thromb. Res. | pmid:6857605 |
| Chilton FH et al. | Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils. | 1983 | J. Biol. Chem. | pmid:6408071 |
| Lecrubier C et al. | Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin. | 1983 | Agents Actions | pmid:6858789 |
| Gonzalez-Crussi F and Hsueh W | Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin. | 1983 | Am. J. Pathol. | pmid:6859226 |
| Camussi G et al. | Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. | 1983 | Am. J. Pathol. | pmid:6859232 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Lumb RH et al. | Spontaneous and protein-catalyzed transfer of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) between phospholipid bilayers. | 1983 | Biochim. Biophys. Acta | pmid:6860678 |
| Suquet CM and Leid RW | Aggregation of equine platelets by PAF (platelet-activating factor). | 1983 | Inflammation | pmid:6862593 |
| Virella G et al. | Release of PAF by human polymorphonuclear leucocytes stimulated by immune complexes bound to Sepharose particles and human erythrocytes. | 1983 | Immunology | pmid:6885111 |
| Camussi G et al. | Platelet-activating factor-mediated contraction of rabbit lung strips: pharmacologic modulation. | 1983 | Immunopharmacology | pmid:6885382 |
| Hubbard JW et al. | Antihypertensive effects of I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on plasma renin activity and catecholamine responses in spontaneously hypertensive rats. | 1983 | Life Sci. | pmid:6337313 |
| Acharya SB and MacIntyre DE | Platelet products and vascular PGI2 production. | 1983 | Prostaglandins Leukot Med | pmid:6338532 |
| Camussi G et al. | Effect of prostacyclin (PGI2) on immune-complex-induced neutropenia. | 1983 | Immunology | pmid:6339375 |
| Billah MM and Lapetina EG | Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6341992 |
| Lapetina EG and Siegel FL | Shape change induced in human platelets by platelet-activating factor. Correlation with the formation of phosphatidic acid and phosphorylation of a 40,000-dalton protein. | 1983 | J. Biol. Chem. | pmid:6345519 |
| Camussi G et al. | Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. | 1983 | Prostaglandins | pmid:6346397 |
| Iñarrea P et al. | Platelet-activating factor: an effector substance of the vasopermeability changes induced by the infusion of immune aggregates in the mouse. | 1983 | Immunopharmacology | pmid:6347969 |
| Satouchi K | [Platelet activating factor (PAF)--a new chemical mediator of inflammation]. | 1983 | Seikagaku | pmid:6350499 |
| Lin AH et al. | Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. | 1982 | J. Clin. Invest. | pmid:6290535 |
| Vargaftig BB et al. | Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. | 1982 | Thromb. Res. | pmid:7164036 |
| Mencia-Huerta JM et al. | Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. | 1982 | J. Immunol. | pmid:7086143 |
| Wykle RL et al. | Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. | 1982 | FEBS Lett. | pmid:7084476 |
| Sánchez-Crespo M et al. | Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. | 1982 | Immunopharmacology | pmid:7085259 |
| Bach MK | Mediators of anaphylaxis and inflammation. | 1982 | Annu. Rev. Microbiol. | pmid:6128957 |
| Mueller HW et al. | Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. | 1982 | Lipids | pmid:7087685 |
| Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
| Chilton FH et al. | Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1982 | J. Biol. Chem. | pmid:6802816 |
| Vargaftig BB et al. | Degranulation of rabbit platelets with PAF-acether: a new procedure for unravelling the mode of action of platelet-activating substances. | 1982 | Thromb. Haemost. | pmid:7135345 |
| Sancho J et al. | The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. | 1982 | Immunology | pmid:7141463 |
| Sybertz EJ et al. | Studies on the interactions of acetyl glycerol ether phosphoryl choline with the sympathetic nervous system in rats. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7143227 |
| Cabot MC et al. | Metabolism of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by cell cultures. | 1982 | Life Sci. | pmid:7162357 |
| Tsien WH et al. | Variable responses of human platelets to synthetic platelet activating factor and their modification by epinephrine. | 1982 | Thromb. Res. | pmid:7164038 |
| Vargaftig BB | Platelet-activating factor (PAF-acether) | 1982 | Agents Actions | pmid:7164939 |
| Bette P and Bienvenue A | Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. | 1982 | Agents Actions | pmid:7164940 |
| Roubin R et al. | Release of platelet-activating factor (PAF-acether) and leukotrienes C and D from inflammatory macrophages. | 1982 | Eur. J. Immunol. | pmid:6122581 |
| O'Flaherty JT | Lipid mediators of inflammation and allergy. | 1982 | Lab. Invest. | pmid:6126615 |
| Pinckard RN | The "new" chemical mediators of inflammation. | 1982 | Monogr Pathol | pmid:6126808 |
| Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
| Chignard M et al. | Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet-activating factor (PAF-acether) in the guinea pig. | 1982 | Eur. J. Pharmacol. | pmid:6804248 |
| Shukla SD and Hanahan DJ | AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6288030 |
| Alonso F et al. | Modulatory role of cyclic AMP in the release of platelet-activating factor from human polymorphonuclear leucocytes. | 1982 | Immunology | pmid:6277775 |
| Rao GH et al. | Human platelet activation by an alkylacetyl analogue of phosphatidylcholine. | 1982 | Biochim. Biophys. Acta | pmid:6280777 |
| Ingraham LM et al. | Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. | 1982 | Blood | pmid:6282362 |
| Valone FH et al. | Specific binding of phospholipid platelet-activating factor by human platelets. | 1982 | J. Immunol. | pmid:6286773 |
| Lüscher EF | The role of blood cells and of the vessel wall in the induction of intravascular coagulation. | 1982 | Klin. Wochenschr. | pmid:6750223 |
| Yasaka T et al. | Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). | 1982 | J. Immunol. | pmid:6278021 |
| Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
| Myśliwiec M and Myśliwiec B | [Blood platelets, prostaglandin and complement interactions in inflammation]. | 1982 | Prz. Lek. | pmid:6753039 |
| Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
| Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
| Bruni A and Palatini P | Biological and pharmacological properties of phospholipids. | 1982 | Prog Med Chem | pmid:6758038 |
| Masugi F et al. | [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. | 1982 | Tanpakushitsu Kakusan Koso | pmid:6758041 |
| Modiano A and Belisario A | [Recent information on PAF (Platelet Activating Factor) in hemocoagulative and immuno-allergic processes]. | 1982 | G Clin Med | pmid:6762313 |
| Marcus AJ et al. | Arachidonic acid metabolism in endothelial cells and platelets. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6762834 |
| Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
| Caillard CG et al. | Hypotensive activity of PAF-acether in rats. | 1982 | Agents Actions | pmid:6299079 |
| Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |
| Camussi G et al. | Release of platelet-activating factor from HL-60 human leukemic cells following macrophage-like differentiation. | 1982 | Blood | pmid:6947829 |
| Ishii H et al. | A platelet aggregating substance contained in xanthine oxidase preparation from cow's milk. | 1982 | Thromb. Res. | pmid:6897588 |
| Smith RJ and Bowman BJ | Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803804 |