Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hepatitis C, Chronic D019698 12 associated lipids
Coronary Stenosis D023921 6 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Encephalitis D004660 15 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Contracture D003286 3 associated lipids
Stomatitis D013280 14 associated lipids
Weight Loss D015431 56 associated lipids
Endotoxemia D019446 27 associated lipids
Blister D001768 16 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Lupus Nephritis D008181 8 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Ileal Diseases D007077 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Lee T et al. Increased biosynthesis of platelet-activating factor in activated human eosinophils. 1984 J. Biol. Chem. pmid:6425292
Hallam TJ et al. Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. 1984 Biochem. J. pmid:6426464
Kamitani T et al. Mechanism(s) of the hypotensive effect of synthetic 1-O-octadecyl-2-O-acetyl-glycero-3-phosphorylcholine. 1984 Eur. J. Pharmacol. pmid:6144557
Tokumura A et al. Contractile effect of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine on strips of isolated rat intestine. 1984 J. Pharm. Pharmacol. pmid:6144763
Pirotzky E et al. Release of platelet-activating factor, slow-reacting substance, and vasoactive amines from isolated rat kidneys. 1984 Kidney Int. pmid:6144811
Gómez-Cambronero J et al. The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). 1984 Biochem. J. pmid:6146309
Morley J et al. The platelet in asthma. 1984 Lancet pmid:6150192
Kloprogge E and Akkerman JW Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. 1984 Biochem. J. pmid:6150705
Hanahan DJ and Nelson DR Phospholipids as dynamic participants in biological processes. 1984 J. Lipid Res. pmid:6152281
Malpass TW et al. The effect of prostacyclin infusion on platelet hemostatic function in patients undergoing cardiopulmonary bypass. 1984 J. Thorac. Cardiovasc. Surg. pmid:6231433
Willoughby WF and Willoughby JB Immunologic mechanisms of parenchymal lung injury. 1984 Environ. Health Perspect. pmid:6234162
Sills RH Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. 1984 Am J Pediatr Hematol Oncol pmid:6442830
Lartigue-Mattei C et al. Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. 1984 Agents Actions pmid:6532184
Kulikov VI et al. [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. 1984 Biokhimiia pmid:6542803
Nagata K et al. [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. 1984 Rinsho Ketsueki pmid:6542941
Pirotzky E et al. PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. 1984 Microcirc Endothelium Lymphatics pmid:6546141
Bussolino F et al. Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. 1984 Cell Calcium pmid:6549153
Pirotzky E et al. Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. 1984 Lab. Invest. pmid:6492758
Hwang SB et al. Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. 1984 Thromb. Res. pmid:6429890
Colditz IG and Movat HZ Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. 1984 J. Immunol. pmid:6470487
Patterson R et al. Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. 1984 J. Lab. Clin. Med. pmid:6470563
Lenihan DJ and Lee TC Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732789
Ludwig JC et al. Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. 1984 Arch. Biochem. Biophys. pmid:6430234
Kasuya Y et al. Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. 1984 Can. J. Physiol. Pharmacol. pmid:6733593
Page CP et al. Platelets and bronchospasm. 1984 Int. Arch. Allergy Appl. Immunol. pmid:6735490
Söling HD et al. Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. 1984 Eur. J. Biochem. pmid:6207023
Jouvin-Marche E et al. Biosynthesis of Paf-acether (platelet-activating factor). VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. 1984 J. Immunol. pmid:6736649
Renal syndromes and nonsteroidal antiinflammatory drugs. 1984 N. Engl. J. Med. pmid:6738607
Hoffman DR et al. Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. 1984 Res. Commun. Chem. Pathol. Pharmacol. pmid:6739956
Mohanty D and Hilgard P A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. 1984 Thromb. Haemost. pmid:6740552
Kasuya Y et al. Possible role of endothelium in the vasodilator response of rat thoracic aorta to platelet activating factor (PAF). 1984 J. Pharmacobio-dyn. pmid:6726619
O'Neill C and Saunders DM Assessment of embryo quality. 1984 Lancet pmid:6149413
Gunby P A new piece for the puzzle of inflammation. 1984 JAMA pmid:6420583
Lian EC et al. Purification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasma. 1984 Thromb. Res. pmid:6420930
Billah MM and Siegel MI Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6422930
Prevost MC et al. Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. 1984 Biochem. Biophys. Res. Commun. pmid:6422938
Wodzinowska B and Krajewski T [Role of blood platelets and their membrane in the process of hemostasis]. 1984 Jan-Feb Postepy Hig Med Dosw pmid:6093087
Vemulapalli S et al. Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. 1984 Jul-Aug Hypertension pmid:6378787
Cox CP et al. VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). 1984 Mar-Apr Peptides pmid:6206481
Billah MM et al. Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. 1985 Prostaglandins pmid:3936121
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
Sturk A et al. Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. 1985 Thromb. Res. pmid:2934863
Terashita Z et al. Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. 1985 Biochem. Pharmacol. pmid:2986648
Vanderwel M and Haslam RJ Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. 1985 J. Clin. Invest. pmid:2991338
Naccache PH et al. Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. 1985 Biochem. Biophys. Res. Commun. pmid:2992480
MacIntyre DE et al. Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. 1985 FEBS Lett. pmid:2993027
Hayashi H et al. Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. 1985 J. Biochem. pmid:2993272
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Weber N and Mangold HK Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. 1985 J. Lipid Res. pmid:3891896
Hanahan DJ and Weintraub ST Platelet-activating factor isolation, identification, and assay. 1985 Methods Biochem Anal pmid:3894881
Murer EH The role of platelet calcium. 1985 Semin. Hematol. pmid:3901271
Davis JW et al. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. 1985 Clin. Pharmacol. Ther. pmid:3987176
O'Neill C Examination of the causes of early pregnancy-associated thrombocytopenia in mice. 1985 J. Reprod. Fertil. pmid:3989801
Kertscher HP and Ostermann G [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. 1985 Pharmazie pmid:3991788
Wal F et al. PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. 1985 Thromb. Haemost. pmid:3992525
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Kumar R et al. Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. 1985 Biochim. Biophys. Acta pmid:3839684
Hayashi H et al. Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. 1985 J. Biochem. pmid:3839790
Tokumura A et al. Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. 1985 J. Biol. Chem. pmid:3840169
Sánchez-Crespo M et al. Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. 1985 Immunopharmacology pmid:3840779
Foa R et al. Release of platelet-activating factor in human leukemia. 1985 Cancer Res. pmid:3861246
Otsuka A et al. Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. 1985 Prostaglandins Leukot Med pmid:3862138
Hallam TJ et al. Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. 1985 Adv. Exp. Med. Biol. pmid:3010663
Gerrard JM et al. Platelet protein phosphorylation. 1985 Adv. Exp. Med. Biol. pmid:3010667
Haslam RJ et al. Receptor-effector coupling in platelets: roles of guanine nucleotides. 1985 Adv. Exp. Med. Biol. pmid:3010668
Shigenobu K et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. 1985 J. Pharmacobio-dyn. pmid:4009403
Saeki S et al. Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. 1985 Life Sci. pmid:4010479
Nunn B et al. Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. 1985 Antimicrob. Agents Chemother. pmid:4015075
Weintraub ST et al. Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1985 Biochem. Biophys. Res. Commun. pmid:4015656
Zimmerman GA et al. Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. 1985 Circulation pmid:3928193
Archer CB et al. Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? 1985 Br. J. Dermatol. pmid:4015978
Morley J et al. The role of circulating cells in skin reactions. 1985 Br. J. Dermatol. pmid:4015983
Pirotzky E et al. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? 1985 Br. J. Dermatol. pmid:4015984
Ohno M et al. An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. 1985 Chem. Pharm. Bull. pmid:4017109
O'Neill C et al. Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. 1985 J In Vitro Fert Embryo Transf pmid:4020241
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Darius H et al. Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. 1985 J. Pharmacol. Exp. Ther. pmid:2997428
Benveniste J and Chignard M A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? 1985 Circulation pmid:3928192
Suemune H et al. Synthetic studies on platelet-activating factor (PAF). 1985 Chem. Pharm. Bull. pmid:4028291
Parente L et al. The release of lyso-PAF from guinea-pig lungs. 1985 Eur. J. Pharmacol. pmid:4029263
Hanahan DJ et al. A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. 1985 J. Lipid Res. pmid:4067422
Pedersen AK and FitzGerald GA Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. 1985 Clin. Pharmacol. Ther. pmid:3917387
Mushayakarara EC and Mantsch HH Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. 1985 Can. J. Biochem. Cell Biol. pmid:4075223
Zimmerman GA et al. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. 1985 J. Clin. Invest. pmid:4077977
Young JM et al. Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. 1985 Prostaglandins pmid:4081060
Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. 1985 Prostaglandins pmid:4081064
Valone FH and Johnson B Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. 1985 Thromb. Res. pmid:4082115
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Handley DA et al. Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. 1985 Thromb. Haemost. pmid:4089809
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Vanhoutte PM and Houston DS Platelets, endothelium, and vasospasm. 1985 Circulation pmid:3861273
Hallam TJ et al. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. 1985 Biochem. J. pmid:4091795
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Oda M et al. Production of platelet-activating factor by washed rabbit platelets. 1985 J. Lipid Res. pmid:3934305
Weisman SM et al. Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. 1985 J. Pharmacol. Exp. Ther. pmid:3862805
Orlov SM et al. [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. 1985 Biokhimiia pmid:2408682
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921