| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
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| Cheung HT et al. | Inhibition of platelet aggregation by diterpene acids from Pinus massoniana resin. | 1994 | Arzneimittelforschung | pmid:8135873 |
| Kapui Z et al. | Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. | 1999 | Arzneimittelforschung | pmid:10483515 |
| David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
| Takayama K et al. | Changes in endothelial vasoactive substances under recombinant human erythropoietin therapy in hemodialysis patients. | 1991 Jul-Sep | ASAIO Trans | pmid:1836334 |
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| Ando M et al. | Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6209, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2088253 |
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| Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
| Tsai JJ et al. | Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. | 1993 | Asian Pac. J. Allergy Immunol. | pmid:8216559 |
| Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
| Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
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| Beck JC et al. | Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. | 1991 | Autoimmunity | pmid:1777555 |
| Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
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| Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
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| Pearson JD | The control of production and release of haemostatic factors in the endothelial cell. | 1993 | Baillieres Clin. Haematol. | pmid:8025346 |
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| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Felix SB et al. | Cardiovascular reactions and respiratory events during platelet activating factor-induced shock. | 1990 May-Jun | Basic Res. Cardiol. | pmid:2383216 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Jerusalinsky D et al. | Effect of antagonists of platelet-activating factor receptors on memory of inhibitory avoidance in rats. | 1994 | Behav. Neural Biol. | pmid:7945139 |
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| Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
| Kuruvilla A et al. | High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659411 |
| Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Dillon AM and Heath MF | The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7542881 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
| Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
| Hayashi M et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445360 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Shukla SD and Hanahan DJ | AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6288030 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
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| Blank ML et al. | A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696762 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
| Levi R et al. | Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2742592 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
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| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
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| Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
| Smith RJ and Bowman BJ | Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803804 |
| Lumb RH et al. | PAF-acether transfer activity in HL-60 cells is induced during differentiation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2169726 |
| Kroegel C et al. | Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2546554 |
| Nishinaka Y et al. | A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390246 |
| Shiono S et al. | Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390248 |
| Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
| Ng DS and Wong K | GTP regulation of platelet-activating factor binding to human neutrophil membranes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026378 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |